N-terminus
Characterization of Replication-Competent Hepatitis A Virus Constructs Containing Insertions at the N Terminus of the Polyprotein
... Although IRES elements of the different picornaviruses show little sequence homology, computer-assisted RNA fold- ing predictions showed three distinct groups (for a review, see reference 25): (i) enteroviruses and ...
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Modification of the 5′ Terminus of Sindbis Virus Genomic RNA Allows nsP4 RNA Polymerases with Nonaromatic Amino Acids at the N Terminus To Function in RNA Replication
... an N-terminal aromatic amino acid or histidine for wild-type or pseudo-wild-type function; mutant viruses with a nonaromatic amino acid at the N terminus of the polymerase, but which are otherwise ...
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Regulation of SAGA by the N-terminus of Spt7 in Saccharomyces cerevisiae
... Horiuchi et al. 2007). In the absence of cellular inositol, SAGA via its Gcn5 subunit acetylates lysine 14 of histone H3 after its recruitment to the promoter by Snf1 (Lo et al. 2005). Likewise, SAGA controls the ...
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Requirement for an Aromatic Amino Acid or Histidine at the N Terminus of Sindbis Virus RNA Polymerase
... the N-end rule pathway (5), in which the stability of a protein is dependent on the amino acid at its N terminus ...The N-terminal amino acid of Sindbis virus nsP4 is Tyr, which is a ...
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Human Foamy Virus Capsid Formation Requires an Interaction Domain in the N Terminus of Gag
... Retroviral Gag expression is sufficient for capsid assembly, which occurs through interaction between distinct Gag domains. Human foamy virus (HFV) capsids assemble within the cytoplasm, although their budding, which ...
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Humanized monoclonal antibody armanezumab specific to N-terminus of pathological tau: characterization and therapeutic potency
... target N-terminus of Tau exposed in caspase- cleaved ...extracellular N-terminal tau fragments se- creted by iPSC cortical neurons from AD ...
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Role of N Terminus-Truncated NS1 Proteins of Influenza A Virus in Inhibiting IRF3 Activation
... the N-terminally truncated NS1 Ud and PR8 ...17-kDa N terminus-truncated NS1 proteins, we determined their sites of cellular ...two N terminus-truncated NS1 proteins in transfected HeLa ...
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Synaptotagmin I delays the fast inactivation of Kv1.4 channel through interaction with its N-terminus
... the N-terminus of Kv1.4 channel to delay its fast N-terminal inactivation in a Ca 2+ -depedent ...between N- and C-type inacti- vated states ...although N- and C-type inactivation ...
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The Trypanosomatid-Specific N Terminus of RPA2 Is Required for RNA Polymerase I Assembly, Localization, and Function
... the N- terminal ...the N-terminal region but instead by virtue of an NLS on another pol I subunit with which it interacts, then the disruption of this interaction would also disrupt the nuclear import of ...
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Pluripotent stem cells reveal erythroid specific activities of the GATA1 N terminus
... GATA1 N-terminus (or lack thereof) affects hematopoiesis separately or in combination with T21 has been challenging, partly due to lack of ideal experimental ...GATA1 N-termi- nus by analyzing ...
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Importance of the N Terminus of Rous Sarcoma Virus Protease for Structure and Enzymatic Function
... five N-terminal amino acid residues and a similar stretch of residues from the C ...the N-terminal leucine reduced enzymatic activity on peptide and protein substrates 100- to ...three N-terminal ...
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Antibodies to the Buried N Terminus of Rhinovirus VP4 Exhibit Cross-Serotypic Neutralization
... buried N termini of viral protein 1 (VP1) and ...the N terminus of ...the N termini of VP4 are interacting with each other upon extrusion from the ...
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A Basic Cluster in the N Terminus of Yellow Fever Virus NS2A Contributes to Infectious Particle Production
... A defect in particle production, but not in viral RNA replica- tion, was observed for our first triple mutant, the R22A-K23A- R24A mutant. In contrast, double mutants involving these resi- dues (R22A-K23A and R22A-R24A) ...
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Characterization of the AdoMet-Dependent Guanylyltransferase Activity That Is Associated with the N Terminus of Bamboo Mosaic Virus Replicase
... C terminus and methyltransferase activity residing at the N ter- ...the N-terminal portion has meth- yltransferase activity that catalyzes the transfer of a methyl group from AdoMet to GTP or ...the ...
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Mutations in the N Terminus of the Brome Mosaic Virus Polymerase Affect Genetic RNA-RNA Recombination
... the N-terminal domain of 2a, the putative RNA polymerase protein, participates in the interactions between 1a and 2a ...the N terminus of 2a influence RNA recombination in ...2a N-terminal ...
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The Phosphoprotein (P) Binding Site Resides in the N Terminus of the L Polymerase Subunit of Sendai Virus
... the N terminus to the C terminus of the protein, which were pro- posed to specify the essential activities common to all L pro- teins (14, ...
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The N Terminus of Andes Virus L Protein Suppresses mRNA and Protein Expression in Mammalian Cells
... hantavirus N protein colocalizes with P bodies in the cytoplasm of infected cells ...the N-terminal ...the N terminus containing the putative endonuclease determines the colocaliza- tion with ...
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Regulating repression : roles for the Sir4 N terminus in linker DNA protection and stabilization of epigenetic states
... The N-terminal half of Sir4 is dispensable for SIR–mediated repression of HM loci in vivo, except in strains that lack Yku70 or have weak silencer ...an N-terminal domain (Sir4N; residues 1–270), expressed ...
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The N Terminus of Phosphodiesterase TbrPDEB1 of Trypanosoma brucei Contains the Signal for Integration into the Flagellar Skeleton
... The N terminus of PDEB1, but not that of PDEB2, confers integration into the flagellar ...entire N terminus of PDEB1 but that lacks the first 114 amino acids is not integrated into the ...
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Deconstructing honeybee vitellogenin: novel 40 kDa fragment assigned to its N terminus
... vitellogenin N terminus using mass spectroscopy, and establish that the corresponding polypeptide is missing from the previously reported 150kDa vitellogenin ...small N-terminal fragment (40kDa) ...
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