Nuclear factor-κB (NF-κB) signaling
Dermatan sulfate activates nuclear factor κb and induces endothelial and circulating intercellular adhesion molecule 1
... cell NF-κB within 30 minutes. Fur- thermore, inhibition of NF-κB signaling by PDTC blocked DS-induced ICAM-1, thus suggesting that DS increases ICAM-1 through ...autocrine ...
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NF- B signaling mediates acquired resistance after PARP inhibition
... of Nuclear Factor- κB (NF-κB) pathways in the resistant ...clones. NF-κB is a complex of transcription factors that consisting of p65 (RelA) and p50 (NFκB1) or RelB and ...
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... A nuclear factor-κB (NF-κB)-dependent inflammatory pathway, which produces inflammatory cytokines, and hypoxia-in- ducible factor-1 (HIF-1)-dependent adaptive pathway ...active ...
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The roles of the classical and alternative nuclear factor kappaB pathways: potential implications for autoimmunity and rheumatoid arthritis
... growth factor genes and IL-17Rs and Toll and IL-1R), which is distantly related to the Toll and IL-1R (TIR) ...activates NF- κ B and mitogen- activated protein kinases via CIKS/Act1, although the molecular ...
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Original Article Role of Toll-like receptor 2/NF-κB signaling pathway in the pathogenesis of allergic rhinitis
... (TLR2)/nuclear factor (NF)-κB signaling pathway in the pathogenesis of allergic rhinitis ...and NF-κB protein expression levels were ...and NF-κB expression, ...
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Original Article A database and functional annotation of NF-κB target genes
... transcription factor NF-κB always be induced by many inducers, and can regulate the expressions of many ...of NF-κB target ...all NF-κB target genes identified to date, ...
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Atypical IκB proteins – nuclear modulators of NF-κB signaling
... Nuclear factor κ B (NF- κ B) controls a multitude of physiological processes such as cell differentiation, cytokine expression, survival and ...Since NF- κ B governs embryogenesis, tissue ...
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Original Article EGCG suppresses NF- B activation induced by gastroesophageal reflux contents in human esophageal epithelial cells
... the nuclear factor kappa-light-chain- enhancer of activated B cells (NF-κB) signaling pathway in normal human esophageal epithelial cells (HEECs) and the effect of EGCG pretreatment of ...
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Anti inflammatory effect of Prunus yedoensis through inhibition of nuclear factor κB in macrophages
... Cellular proteins were extracted from PY treated RAW 264.7 cells in the presence or absence of LPS (10 μg/ml) for 18 h. Cells were collected by centrifugation and washed once with ice-colded phosphate buffered saline ...
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Original Article GF109203X attenuates RANKL-induced osteoclastogenesis and suppresses osteolysis in a mouse model
... sis factor (TNF) super family, and is primarily secreted by the ossification cells, T lympho- cytes, and B lymphocytes ...RANKL-mediated signaling pathways, RANKL links to RANK and causesinhibitor kappa B ...
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Atractylenolide I modulates ovarian cancer cell mediated immunosuppression by blocking MD 2/TLR4 complex mediated MyD88/NF κB signaling in vitro
... We have demonstrated that TLR4/MD-2 complex-medi- ated activation of MyD88/NF-kB is the major mechanism for immunosuppression through induction of immu- nosuppressive molecules and generation of immuno- ...
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Crosstalk between the canonical NF κB and Notch signaling pathways inhibits Pparγ expression and promotes pancreatic cancer progression in mice
... canonical NF-κB signaling and, in collaboration with basal Notch signals, induced optimal expression of Notch ...antiinflammatory nuclear receptor ...
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... important factor for preterm labor related to inflammation (COX-2 and prostaglandin) is NF- κB which is activated by numbers of inflammatory mediators, including cytokines and lipopolysaccharide ...
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Secretory leukocyte protease inhibitor suppresses HPV E6-expressing HNSCC progression by mediating NF-κB and Akt pathways
... Fig. 4 Relative activation of NF-κB and Akt pathways and SLPI downregulation in HPV positive HNSCC. a, b The proportion of p65 expressed in the cell nucleus in HPV positive tissues was significantly higher ...
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A systems biology approach to explore the dynamics and interactions of the NF-κB signalling pathway
... There is a corresponding biological context to the understanding of small parameter changes being introduced to the model, particularly with regard to modulation by post-translation modifications of NF-κB. ...
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Anti Inflammatory properties of Salograviolide A purified from Lebanese plant Centaurea ainetensis
... on NF-κB activa- tion levels. Under basal conditions, NF-κB, a transcription factor, is maintained in an inactive form by IκB inhibitory ...freeing NF- κB to translocate ...
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Enhanced expression of genes involved in coagulation and fibrinolysis in murine arthritis
... The transcriptional regulation of the changes noted are not completely understood. The increases in TF, PAI-1, and uPA are most likely to be due to the increased secretion of cytokines such as IL-1 and TNF-α, which are ...
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Trop2 and its overexpression in cancers: regulation and clinical/ therapeutic implications
... The Trop2-mediated signaling pathways and transcription factors that regulate its expression are still unclear. An expansion of the mechanisms of Trop2 regulation and miRNA regulation of Trop2 expression along ...
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Original Article Inhibition of the NF-κB pathway by R65 ribozyme gene via adeno-associatedvirus serotype 9 ameliorated oxidized LDL induced human umbilical vein endothelial cell injury
... Objective: NF-κB signaling plays a central role in the regulation of inflammatory responses in atheroscle- ...of NF-κB pathway, therefore we studied whether R65 gene therapy can ...
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Original Article CXCR4 was involved in andrographolide inhibits atherosclerosis by inactivating the PI3K/AKT/NF-κB signaling pathway
... PI3K/AKT/NF-κB signaling pathway during ...PI3K/AKT/NF-κB signaling pathways by regulating the CXCR4 and make EC-SMC-MC have anti-inflammatory ...
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