Phosphorylation site
Improved Protein Phosphorylation Site Prediction by a New Combination of Feature Set and Feature Selection
... In this work, we followed the preparation step done by Ismail [11]. The dataset we use were down- loaded from the Phospho SVM website [12]. The phosphorylation site data set is P.ELM version 9 [13]. The ...
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Phosphorylation Site Mutations Affect Herpes Simplex Virus Type 1 ICP0 Function
... distinct phosphorylation signals as determined by phosphotryptic peptide mapping ...Since phosphorylation affects the activities of many viral regulatory proteins, we sought to determine whether the ...
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Phosphorylation of the MAPKKK Regulator Ste50p in Saccharomyces cerevisiae: a Casein Kinase I Phosphorylation Site Is Required for Proper Mating Function
... CKI phosphorylation (reference 45 and references ...Yck1p phosphorylation site(s) is among the first eight S/T ...Yck1p phosphorylation site in ...Yck1p phosphorylation ...
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Characterization of a Human Cytomegalovirus with Phosphorylation Site Mutations in the Immediate-Early 2 Protein
... kinase-mediated phosphorylation of IE2 protein may reduce the protein’s transcriptional activation ...protein phosphorylation site mu- tant, with alanine mutations at T27, S144, T233, and S234, ...
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A Hepatitis C Virus NS5A Phosphorylation Site That Regulates RNA Replication
... a site of phosphorylation used in cells harboring a func- tional replicon, the first site to be found in the context of RNA ...the phosphorylation of other sites in NS5A that are com- ponents ...
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PhosSA: Fast and accurate phosphorylation site assignment algorithm for mass spectrometry data
... Phosphorylation site assignment of high throughput tandem mass spectrometry (LC-MS/MS) data is one of the most common and critical aspects of ...incorporate site assignment; therefore additional ...
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PhosPhAt : the Arabidopsis thaliana phosphorylation site database : an update
... and phosphorylation sites from independent studies is a good approach for true positive identifications, the absence of overlap is not immediately an indication of falsely detected phosphorylation ...and ...
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Mutation of a protein kinase C phosphorylation site in the erbB protein of avian erythroblastosis virus.
... RESULTS To investigate the relationship between TPA-dependent phosphorylation of threonine 98 of the erbB protein and TPA-dependent inhibition of growth of AEV-transformed cells, we made[r] ...
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Threonine175, a novel pathological phosphorylation site on tau protein linked to multiple tauopathies
... pathological phosphorylation sites on tau, such as pThr 231 and pSer 202 , pThr 175 has not been observed in the fetal brain where tau protein is hyperphosphorylated [14–16], suggesting that this site may ...
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Characterization of partially activated p60c-src in chicken embryo fibroblasts.
... This indicates that not the change of the primary amino acid sequence but either the tyrosine phosphorylation site itself or a conformational change that accompanies the alteration of ty[r] ...
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Mitotic Regulation of Protein Kinase CK2
... CK2α phosphorylation sites had any effect on cell proliferation, we analyzed the growth of cells expressing CK2α -HA, CK2α -4D- HA, CK2α -4E- HA, or CK2α -4A-HA in combination with Myc- ...three ...
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Protein kinase A and C site specific phosphorylations of LAP (NF IL6) modulate its binding affinity to DNA recognition elements
... phosphorylation site of LAP was identified as Ser105, which is a predicted PKA ...PKA phosphorylation site disappears after mutation of Ser105 to ...that phosphorylation of Ser105 ...
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Stability of Structured Kaposi's Sarcoma-Associated Herpesvirus ORF57 Protein Is Regulated by Protein Phosphorylation and Homodimerization
... Protein phosphorylation is a reversible posttranslational modifi- cation which affects protein localization, folding, binding activi- ties, stability, ...that phosphorylation modu- lates substrate ...
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Norovirus RNA-Dependent RNA Polymerase Is Phosphorylated by an Important Survival Kinase, Akt
... RdRp phosphorylation event in vivo and determining its impact on viral replication and whether this favors the host or the ...the phosphorylation site into the exist- ing murine NoV infectious cell ...
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Phosphorylation of Human Metapneumovirus M2-1 Protein Upregulates Viral Replication and Pathogenesis
... example, phosphorylation of the NP protein of measles virus (38), rabies virus (37), and Nipah virus (39) has been shown to upregulate transcriptional ...contrast, phosphorylation of mumps virus NP ...
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Steady-State Plasma Membrane Expression of Human Cytomegalovirus gB Is Determined by the Phosphorylation State of Ser900
... glycoprotein phosphorylation can affect the steady-state ex- pression of a protein at the ...the phosphorylation site, which mimics the phosphorylation state, results in gB vacuoles that ...
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Using microscopy to manipulate and visualize signal transduction in living cells
... phosphorylation site effects adhesion site formation, size and assembly rates; using large data sets, even subtle differences are easily detected at a significant level.. These results [r] ...
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Proteomic database mining opens up avenues utilizing extracellular protein phosphorylation for novel therapeutic applications
... functional consequences needs to be seen. The residue T1148 in the C-propeptide region of the human pro- collagen α2(I) chain has been shown by mass spec- trometry to be phosphorylated [72] (Figure 3B, boxed). This ...
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Page_unc_0153D_15827.pdf
... The phosphorylation state of the sensory component, the sensor kinase (SK), is regulated by the presence of ...the phosphorylation of its own conserved histidine with the γ-phosphoryl group of ...
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Phosphorylation-Dependent Targeting of Tetrahymena HP1 to Condensed Chromatin
... ABSTRACT The evolutionarily conserved proteins related to heterochromatin pro- tein 1 (HP1), originally described in Drosophila, are well known for their roles in het- erochromatin assembly and gene silencing. Targeting ...
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