Polycomb repressive complex 2 (PRC2)
Epigenetic changes mediated by polycomb repressive complex 2 and E2a are associated with drug resistance in a mouse model of lymphoma
... the polycomb repressive complex 2 (PRC2) Suz12 and Pcl2 were very strongly enriched over positively covarying genes, sug- gesting an involvement of this complex in mediating epi- ...
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Oxygen-dependent proteolysis regulates the stability of angiosperm polycomb repressive complex 2 subunit VERNALIZATION 2
... The polycomb repressive complex 2 (PRC2) regulates epigenetic gene repression in eukar- ...plant PRC2 subunit VERNALIZATION(VRN) 2, a homolog of animal Su(z)12, that ...
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Choi, Jeongyoon (2016): Structural and functional analysis of polycomblike-polycomb repressive complex-2. Dissertation, LMU München: Fakultät für Chemie und Pharmazie
... the Polycomb repressive complex 2 (PRC2) consists of E(z), Su(z)12, Esc and Nurf55 as core subunits, and the complex mono-, di-, and tri- methylates histone H3 lysine 27 ...of ...
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Polycomb Repressive Complex 2 Silences Human Cytomegalovirus Transcription in Quiescent Infection Models
... HMT complex PRC2 (Polycomb repressive complex 2) (23, ...24). PRC2 is composed of EZH2, the catalytic methyltrans- ferase subunit, along with SUZ12 and ...EED. PRC2 ...
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BRCA1 deficient mammary tumor cells are dependent on EZH2 expression and sensitive to Polycomb Repressive Complex 2 inhibitor 3 deazaneplanocin A
... of polycomb group proteins, which are epigenetic repressors that prevent the expression of cell cycle inhibitors and genes required for dif- ferentiation ...of Polycomb Repressive Complex ...
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Predicting involvement of polycomb repressive complex 2 in direct conversion of mouse fibroblasts into induced neural stem cells
... of polycomb repressive complex 2, Ezh2, Suz12, Mtf2, and Jarid2 are grouped as master regulators in four cell lines based on the number of regulatory interactions and also show the same ...
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Deregulated expression of microRNA-200b/c and SUZ12, a Polycomb repressive complex 2 subunit, in chemoresistant colorectal cancer cells
... of Polycomb group proteins (such as BMI1, SUZ12, and EZH2), and changes in the expression of microRNA-200 (miR-200) ...a Polycomb repressive complex 2 subunit, was upregulated in ...
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Stage and subunit specific functions of polycomb repressive complex 2 in bladder urothelial formation and regeneration
... urothelial cells because of the compensatory effect of Ezh1, as shown in other organ systems including embryonic stem cells, hematopoietic cells and skin (Ezhkova et al., 2011; Shen et al., 2008; Xie et al., 2014). ...
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EZH2 variants differentially regulate polycomb repressive complex 2 in histone methylation and cell differentiation
... interacting with a CXC domain in EZH2 can enhance H3K27 methylation [34]. Consistent with these two studies, ex14D-EZH2, which lacks two C-X(6)-C-X(3)- C-X-C motifs in the CXC domain, exhibited diminished catalytic ...
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Polycomb Repressive Complex 2 Regulates miR-200b in Retinal Endothelial Cells: Possible Implications in Diabetic Retinopathy
... 2.6 PRC2 inhibition with 3-Deazaneplanocin A (DZNep) chemical inhibitor A general methylation inhibitor DZNep (Cayman Chemical, Ann Arbor, MI), which has shown selectivity for PRC2 and H3K27me3, was used as ...
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Chromatin regulated interchange between polycomb repressive complex 2 (PRC2)-Ezh2 and PRC2-Ezh1 complexes controls myogenin activation in skeletal muscle cells
... other PRC2 core components (Suz12 and Eed), including Ezh1, has not yet been ...only PRC2 component that is maintained at constant levels during myogenic differ- entiation, while levels of Ezh2, Suz12 and ...
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Snail2/Slug cooperates with Polycomb repressive complex 2 (PRC2) to regulate neural crest development
... that PRC2 modulates mesendodermal formation in collaboration with the nuclear factor Geminin (Lim et ...of PRC2 RNAs or translational blocking antisense morpholino oligos (MOs) specifically into the animal ...
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Polycomb repressive complex 2 is a critical mediator of allergic inflammation
... Targeting the enzymes that are responsible for laying down epigenetic modifications to chromatin has recently become possible with the design of several inhibitory drugs (30, 31). Concerns that targeting part of the ...
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Drosophila DNA-Binding Proteins in Polycomb Repression
... Drosophila Polycomb group (PcG) proteins. The Polycomb response element (PRE) shown as brown horizontal bar: DNA sequence depleted of nucleosomes (slanted ovals) on which PcG proteins are ...
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Epi-drugs in combination with immunotherapy: a new avenue to improve anticancer efficacy
... homolog 2 (EZH2), a member of polycomb repressive complex 2 (PRC2), regu- late differentiation and plasticity of CD4 + T ...chromatin repressive mark H3K27me3 in activated ...
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Wedelolactone disrupts the interaction of EZH2-EED complex and inhibits PRC2-dependent cancer
... Polycomb repressive complex 2 (PRC2), which is responsible for the trimethylation of H3K27 (H3K27me3), plays a part in tumorigenesis, development and/or maintenance of adult tissue ...
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Polycomb repressive complex’s evolutionary conserved function: the role of EZH2 status and cellular background
... recruits PRC2 for enforcing a repressive chromatin modification at NF-κB target ...of PRC2, dependent on EZH2 threonine 487 (T487) phosphorylation (Prot Q 15910-1), seems to be essen- tial, at least ...
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Unveiling the hidden function of long non-coding RNA by identifying its major partner-protein
... ploycomb repressive com- plex 2 (PRC2) to silence transcription across 40 kb of the HOXC locus in trans by inducing a repressive chro- matin state ...the polycomb complex to the ...
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Gene silencing in HIV 1 latency by polycomb repressive group
... termed polycomb repressive complex 1 (PRC1) and 2 (PRC2) ...silencing. PRC2 is a smaller complex that comprises three main proteins (EZH2, EED and SUZ12) and catalyzes ...
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Genome-wide RNAi screen in Drosophila reveals Enok as a novel trithorax group regulator
... the Polycomb Group (PcG) and the trithorax Group (trxG), that contribute to the maintenance of cellular memory ...complexes, Polycomb Repressive Complex 1 and 2 (PRC1 and PRC2), ...
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