serum response factor
Regulation of cardiac microRNAs by serum response factor
... Serum response factor (SRF) regulates certain microRNAs that play a role in cardiac and skeletal muscle development. However, the role of SRF in the regulation of microRNA expression and microRNA ...
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Serum response factor modulates neuron survival during peripheral axon injury
... Background: The transcription factor SRF (serum response factor) mediates neuronal survival in vitro. However, data available so far suggest that SRF is largely dispensable for neuron survival ...
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Stretch induced alternative splicing of serum response factor promotes bronchial myogenesis and is defective in lung hypoplasia
... Smooth muscle (SM) develops only in organs and sites that sustain mechanical tensions. Therefore, we determined the role of stretch in mouse and human bronchial myogenesis. Sustained stretch induced expression of SM ...
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Reduced nuclear translocation of serum response factor is associated with skeletal muscle atrophy in a cigarette smoke-induced mouse model of COPD
... Abstract: Skeletal muscle atrophy and dysfunction are common complications in the chronic obstructive pulmonary disease (COPD). However, the underlying molecular mechanism remains elusive. Serum response ...
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The Elk-1 and Serum Response Factor Binding Sites in the Major Immediate-Early Promoter of Human Cytomegalovirus Are Required for Efficient Viral Replication in Quiescent Cells and Compensate for Inactivation of the NF-κB Sites in Proliferating Cells
... or serum response factor (SRF) binding site within the enhancer also reduces MIEP activation and viral replication of recombinant HCMV viruses in quiescent ...
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Loss of serum response factor in keratinocytes results in hyperproliferative skin disease in mice
... The transcription factor serum response factor (SRF) plays a crucial role in the development of several organs. However, its role in the skin has not been explored. Here, we show that ...
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Expression and comparative genomics of two serum response factor genes in zebrafish
... ABSTRACT Serum response factor (SRF) is a single copy, highly conserved transcription factor that governs the expression of hundreds of genes involved with actin cytoskeletal organization, ...
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Serum response factor has functional roles both in indirect binding to the CArG box and in the transcriptional activation function of human T-cell leukemia virus type I Tax.
... 11 0022-538X/94/$04.00+0 Copyright C 1994, American Society for Microbiology Serum Response Factor Has Functional Roles both in Indirect Binding to the CArG Box and in the Transcriptiona[r] ...
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Regulation of smooth muscle-specific transcription by serum response factor and formin homology domain containing protein 1
... Several lines of evidence from the current study indicated that T159 phosphorylation has less of an effect on c-fos promoter activity. First, the overall activity of the c-fos promoter was less dependent upon the ...
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Weak up-regulation of serum response factor in gastric ulcers in patients with co-morbidities is associated with increased risk of recurrent bleeding
... intermediate (n = 83), and weak (n = 41) patterns. The most impressive finding was that patients with strong up-regulation of SRF intensity had lower rate of Forrest classification Ia to IIc SRH than patients with either ...
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Blood pressure–associated polymorphism controls ARHGAP42 expression via serum response factor DNA binding
... cells (SMCs) controls blood pressure by inhibiting RhoA-dependent contractility, providing a mechanism for the blood pressure–associated locus within the ARHGAP42 gene. The goals of the current study were to identify ...
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Actin-dependent activation of serum response factor in T cells by the viral oncoprotein tip
... interactions with ternary complex factors (TCFs) or myocardin-related transcription factors (MRTFs). Binding of Rho- and actin-regulated MRTF:SRF complexes to target gene promoters requires an SRF-binding site only, ...
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Mechanochemical Control of Stem Cell Biology in Development and Disease: Experimental and Theoretical Models
... transcription factor (Swift et ...the serum response factor (SRF) pathway that also contributes to osteogenesis (Chen et ...in response to matrix E –– as modeled by the MGC (Figure ...
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CNS axon regeneration inhibitors stimulate an immediate early gene response via MAP kinase-SRF signaling
... In addition, we investigated whether these axon re- generation inhibitors modulate gene expression. So far, activation of NgRs, PIR-B or RPTPs has not been con- nected to modulation of gene expression. We focused on SRF ...
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Index Catalog // Carolina Digital Repository
... that Serum Response Factor (SRF) regulates nearly all of the SMC differentiation marker genes by binding to CArG cis elements within their promoters ...transcription factor strongly activates ...
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Correlation of C reactive protein haplotypes with serum C reactive protein level and response to anti tumor necrosis factor therapy in UK rheumatoid arthritis patients: results from the Biologics in Rheumatoid Arthritis Genetics and Genomics Study Syndicate cohort
... The effect of inflammatory mediators (such as IL-6) and corresponding levels of inflammation may have a role in masking the effect of CRP SNPs on the level of serum CRP. As inflammation settles, levels of other ...
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Fur Is the Master Regulator of the Extraintestinal Pathogenic Escherichia coli Response to Serum
... that serum affects the expres- sion of a broad spectrum of genes with a variety of ...the serum-induced changes are metabolic; the upregulated pathways were mainly those of cations, iron-carrying compounds, ...
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... VEGF-C serum were signs of biomolecular potential for cervical cancer squamous cell ...in serum (p = 0.024), VEGF-C in serum and tissues associated with clinical stage, tumor size, lymphnode ...
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Serum brain derived neurotrophic factor levels and personality traits in patients with major depression
... between serum BDNF levels and scores for the SD personality trait in patients with ...between serum BDNF levels and neuroticism in 118 healthy subjects, evaluated by the Neuroticism-Extroversion-Openness ...
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A LABILE SERUM FACTOR CLOTTING DEFECT: ITS DEMONSTRATION BY THE THROMBOPLASTIN GENERATION TEST AND ITS CLINICAL SIGNIFICANCE
... In 28 of these patients the serum defect fitted well into the labile serum factor classification in that it was corrected by the addition of 0.024 U of thrombin, by the patient's serum a[r] ...
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