THE T-CELL RECEPTOR IN AUTOIMMUNITY
T cell integrin overexpression as a model of murine autoimmunity
... few T cell surface antigens, including LFA-1, are changed following treatment with DNA hypomethylating agents ...of T cell LFA-1 overexpression, a murine CD18 construct (CD18/pSub2) was ...
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Factors Influencing Regulatory T Cell Maintenance for the Control of Autoimmunity
... and T cell receptor (TCR) ...conventional T cells (Tconvs) produce IL-2 in response to self-peptides and that Tconvs possessing TCRs with greater self-reactivity express more IL-2 at ...
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Control of T Cell Responses, Tolerance and Autoimmunity by Regulatory T Cells: Current Concepts
... regulatory T cell function, they share as a drawback the fact that such function occurs under lymphopenic conditions, where T cell homeostasis is dramatically changed by feedback mechanisms ...
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Distinct roles for PTEN in prevention of T cell lymphoma and autoimmunity in mice
... including T cell malignancies. Targeted deletion of Pten in T cells induces both a disseminated “mature phenotype” lymphoma and a lymphoproliferative autoimmune syndrome in ...by T lineage ...
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T cell receptor signaling for γδT cell development
... γδT cell subsets and their precursor-product relationships, and identification of the endogenous γδTCR ligands that control thymic γδT cell ...infection, autoimmunity, and ...
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Single cell T cell receptor sequencing : techniques and future challenges
... and autoimmunity ( 19 ) and in several clinical applications like the monitoring of hematopoietic cell transplantation ( 20 ...a T cell: T cells undergo a process called “allelic ...
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Computational approaches to the analysis of the T cell receptor repertoire
... the T cell compartment of the immune system may use a stochastic set of receptors, whose specificities are not predetermined, to develop a use- ful ...of T cells, and cannot be linked by a one-to-one ...
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The Effect of T Cell Receptor Specificity on CD4+CD25+ Regulatory T Cell Function in an Autoimmune Setting
... multi-organ autoimmunity associated with Foxp3-sf mice, presumably because the TCR repertoire was restricted by expression of the transgenic ...+ T cell depletion by antibody treatment did not appear ...
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The role of Germline-Encoded T cell Receptor Complementarity Determining Regions in T cell Selection and Function
... possible that the less efficient colonisation of empty recipients could have resulted in loss of a functional Treg population – functionality tests from the WT and mutant mice could confirm whether any difference in ...
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The regulation of T cell homeostasis and autoimmunity by T cell–derived LIGHT
... peripheral T cells, which subsequently results in the development of autoimmune disease, but also show that LIGHT may have an essential role in T cell–depend- ent diseases such as ...a T ...
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T cell metabolism in metabolic disease-associated autoimmunity
... 3. T cell metabolism as a potential driving force of inflammation and target for immunomodulation in metabolic disease-associated ...of T cell metabolism is presented as a hub whose (specific) ...
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Splicing factor SRSF1 controls T cell hyperactivity and systemic autoimmunity
... T cell quiescence is enforced by molecules able to restrain T cell activation, and the expression of such molecules generally subsides upon TCR stimulation to enable effector differentiation ...
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Peroxisome Proliferator-Activated Receptor- γ in Thyroid Autoimmunity
... Lymphocytes recruitment Figure 1: Several cell types (e.g., thyrocytes), under the influence of cytokines (such as IFN-𝛾 and TNF-𝛼), can modulate the autoim- mune response through the production of CXCL9, CXCL10, ...
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T cell homeostasis and systemic autoimmunity
... peripheral T cells is controlled are not yet well ...for T cell sur- vival in a resting state, may become overt under certain conditions associated with lymphopenia and lead to T cell ...
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Ageing, autoimmunity and arthritis: T cell senescence and contraction of T cell repertoire diversity – catalysts of autoimmunity and chronic inflammation
... senescent T cells in RA are of importance for their role in perpetuating chronic tissue ...which T-cell stimulation is ...other cell types can be T-cell stimula- ...null T ...
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TLR dependent T cell activation in autoimmunity
... by T Reg cells 98 ...+ T cells promoting IL-10 production and the expansion of T Reg cells, which, in turn, inhibit T H 17 ...of T cells may promote tolerance, at least in the mucosa 99 ...
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T cell co stimulatory pathways in autoimmunity
... CD28 is a separate signaling unit, independent of the TCR activation complex, which is very much in line with the two- signal hypothesis. Initially, it was thought that each of these two signaling pathways would be ...
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T cell signaling abnormalities contribute to aberrant immune cell function and autoimmunity
... The T cell in patients with SLE presents a fascinating pheno- type, which is now better understood after gaining insight into the underlying cell signaling and gene ...why T cells are over- ...
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T Cell repertoire and autoimmunity in multiple sclerosis patients in Sardinia
... –T Cell Repertoire and Autoimmunity in Multiple Sclerosis Patients in Sardinia - International PhD Course in Life Sciences and Biotechnologies– Microbiology and Immunology – University of Sassari, ...
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T cell homeostatic proliferation elicits effective antitumor autoimmunity
... by T cell homeostatic proliferation in the periphery, involving expansion of T cells recognizing self-MHC/peptide ...syngeneic T cells showed tumor growth inhibition when challenged with ...
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