[PDF] Top 20 Analysis of Hepatitis C Virus Hypervariable Region 1 Sequence from Cryoglobulinemic Patients and Associated Controls

... features associated with B-cell clonal expansion and cryoglob- ...phylogenetic analysis did not reveal clustering associated with lymphoproliferative disorders, nor were the N-terminal insertions or ... See full document

... MC patients (and none of those infected by HCV-1) showed an averaged ␻ higher than 1 in the E1/E2 region versus four (50%) of the controls (one with ...MC patients and in ... See full document

... derived from a minor HVR1 variant present in pretreatment serum, which suggested that selective expan- sion of a minor variant occurred during IFN therapy (data not ...responder-relapse patients 6 and 8, ... See full document

... 26 patients from the 136 patients given the standard IFN-␣-2b treatment for chronic hepatitis C (3 MU three times per week for 6 to 12 months) and already enrolled in an observational ... See full document

... Table 1, 30 were simi- larly recognized by both MAbs (16 strongly, 14 poorly or not at ...was associated with only five amino acid sequences including GPKQ, GPQQ, GAKQ, GAQQ, or ...was associated ... See full document

... signature sequence within the amplified region is linked to clearance or persistence of vire- mia, signature pattern analysis was ...representative sequence was chosen for each ...consensus ... See full document

... spontaneous hepatitis C aggravation was recently estimated at only ...chronic hepatitis C (reviewed in references 32 and 47), could also be qualitatively and quantitatively ...our ... See full document

... (2). Hypervariable region 1 (HVR1) of the genome is highly variable among and within patients and can be used to identify individual HCV isolates, which is of particular interest for ... See full document

... Therefore analysis of genetic complexity of this region is imperative for understanding the role of envel- ope gene specifically HVR1 in virus interaction to target cells and its persistence which ... See full document

... reference sequence (GenBank: AJ406073) and translated into amino acid sequences by MEGA (Molecular Evolutionary Genetics Analysis), version ...of sequence populations of different cover- ... See full document

... precise analysis of the hydropathic character of the residues at each HVR1 ...(positions 1 and 8), which were considered truly variable ...2. Analysis of 119 unambiguously genotyped HCV genotype 1b ... See full document

... scripts from the cAvm1 ...samples from chickens inoculated with wild-type avian ...transcripts from parental wild-type HEV replicons and their HVR deletion mutant ...genotype 1 HEV replicon ... See full document

... intrahost virus evolution: the early detection of the HCV variant may be considered the starting sequence for a particular host, allowing easier and better analysis of sequence diversification ... See full document

... level from a study of 23 chronically infected, treatment- naive patients from whom samples were collected every 2 weeks over a period of 16 weeks ...12/23 patients was selected for ultradeep ... See full document

... infected patients (15, 18, 27, ...in patients who had acute self-limiting in- fections of HCV ...Resolving from disease seems therefore to be associated with the early induction of such ... See full document

... 2b-infected patients showed an overrepresentation of males (P ⬍ ...2-infected patients (Table ...1b). Patients infected by newly recognized subtype 2m were of Vietnamese origin ...distinct ... See full document

... of patients (12, 13, ...vaccinia virus has led to the detection of anti-E1 and anti-E2 antibodies in most of the patients studied ...chronic patients carrying the virus but rarely in ... See full document

... comprehensive analysis of the positions of the adaptive envelope mutations is made difficult by the absence of an X-ray or nuclear magnetic resonance structure of the E1/E2 het- ...⌬HVR1 virus, S363F (E1) ... See full document

... in sequence variation, a subset of cloned cDNAs was identified for ...two from the majority clono- type, one from each clonotype consisting of more than 10% of the 33 cloned cDNAs examined, and the ... See full document

... steps. Virus RNA was extracted from 200 ␮l of serum by the guanidinium thiocyanate ...leukemia virus reverse transcriptase ...amino-terminal region of the HCV E2 gene (HVR1) was used ... See full document