[PDF] Top 20 Analysis of sequence diversity in hypervariable regions of the external glycoprotein of human immunodeficiency virus type 1.
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Analysis of sequence diversity in hypervariable regions of the external glycoprotein of human immunodeficiency virus type 1.
... Blood samples were obtained from 11 hemophiliacs infected with HIV-contaminated factor VIII 5840 Downloaded from http://jvi.asm.org/ on November 10, 2019 by guest Nucleotide sequences in[r] ... See full document
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Determinants of human immunodeficiency virus type 1 entry in the CDR2 loop of the CD4 glycoprotein.
... process, regions of CD4 outside the major gp120 binding site may play a ...mutagenic analysis of the CD4 CDR3 region makes a role for this region in either gp120 binding or fusion-related processes unlikely ... See full document
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The highly conserved aspartic acid residue between hypervariable regions 1 and 2 of human immunodeficiency virus type 1 gp120 is important for early stages of virus replication.
... of virus replication are expected to have lower levels of chloramphenicol acetyltransferase (CAT) activity than those infected by wild-type ...wild-type virus were constructed in an envelope ... See full document
5
Broadly Neutralizing Antibodies Targeted to the Membrane-Proximal External Region of Human Immunodeficiency Virus Type 1 Glycoprotein gp41
... Specificity of Fab Z13 and comparison with IgG 4E10. We noticed in early experiments that another anti-gp41 MAb 4E10, generated by combined polyethylene glycol-electrofu- sion of PBMC from a seropositive donor and ... See full document
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Diversity of Human Immunodeficiency Virus Type 1 Subtypes in Western Kenya
... subtype diversity in border areas, analysis of human travels, migration patterns as well as social conditions need to be done, if therapeutic interventions have to be ... See full document
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Determinants of human immunodeficiency virus type 1 envelope glycoprotein oligomeric structure.
... simian immunodeficiency virus env glycoprotein precursors are functionally conserved, since heterodimers of the env glyco- protein precursors form when they are coexpressed in the same cell ... See full document
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Both the V2 and V3 regions of the human immunodeficiency virus type 1 surface glycoprotein functionally interact with other envelope regions in syncytium formation.
... BOSCH* Laboratory of Immunobiology, National Institute of Public Health and Environmental Protection, Bilthoven, The Netherlands To map the regions of the external envelope glycoproteins[r] ... See full document
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Diversity of the envelope glycoprotein among human immunodeficiency virus type 1 isolates of clade E from Asia and Africa.
... the analysis. The interisolate nucleotide sequence distances in clade E can be compared with those in other clades, whose epidemic spread has apparently developed over a different ... See full document
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Mutational analysis of the cleavage sequence of the human immunodeficiency virus type 1 envelope glycoprotein precursor gp160.
... The gp120 amino acid 516 glutamic acid to glycine mutation, the 517 lysine to isoleucine mutation, and the 518 arginine to lysine mutation have no significant effect on either envelope g[r] ... See full document
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Antibody cross-competition analysis of the human immunodeficiency virus type 1 gp120 exterior envelope glycoprotein.
... (a) A32 and 2/11c discontinuous epitopes. The consistency and potency with which the A32 and 2/11c MAbs neutralize HIV-1 are generally very low. For example, no neutralization of the HXBc2 or ADA HIV-1 ... See full document
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Introduction of Exogenous Epitopes in the Variable Regions of the Human Immunodeficiency Virus Type 1 Envelope Glycoprotein: Effect on Viral Infectivity and the Neutralization Phenotype
... V4 regions of three HIV-1 isolates (YU2, JRFL, and HxB2) displaying distinct neutralization phenotypes in response to anti-HIV NAbs; they found that all three pseudotyped viruses were equivalently ... See full document
11
Regions required for CD4 binding in the external glycoprotein gp120 of simian immunodeficiency virus.
... simian immunodeficiency virus (SIV) has been used ex- tensively as an animal model for human immunodeficiency virus (HIV) infection, particularly with a view to the develop- ment of a ... See full document
5
In vivo sequence diversity of the protease of human immunodeficiency virus type 1: presence of protease inhibitor-resistant variants in untreated subjects.
... wild-type sequence of the HIV-2 protease also contains the M463I-V823I ...an analysis of sequences of the reverse transcriptase (RT) coding domain from patients who either had or had not received RT ... See full document
6
Sequence diversity of V1 and V2 domains of gp120 from human immunodeficiency virus type 1: lack of correlation with viral phenotype.
... PCR analysis in MT-2 cells infected with NSI viruses (data not shown), suggesting that the replication of NSI variants is blocked prior to reverse transcription in MT-2 cells ...Phylogenetic analysis showed ... See full document
8
Single amino acid substitution in constant region 1 or 4 of gp120 causes the phenotype of a human immunodeficiency virus type 1 variant with mutations in hypervariable regions 1 and 2 to revert.
... wild-type virus, as measured by reverse transcriptase (RT) activity, were used to infect CD4 1 SupT1 cells and the cultures were monitored every 4 days for RT activity as described pre- viously ... See full document
5
Human immunodeficiency virus type 1 envelope glycoprotein oligomerization requires the gp41 amphipathic alpha-helical/leucine zipper-like sequence.
... the human anti- gp41 MAbs 126-6 and ...gp41 regions that generate the gp41 tertiary and quaternary ...a-helical sequence, Ile-641 to Trp-665 ... See full document
9
Genetic diversity of the envelope glycoprotein from human immunodeficiency virus type 1 isolates of African origin.
... nucleotide sequence of a ...the diversity of HIV-1 within any country but were collected for various clinical and epide- miological ...gag sequence information or results obtained with ... See full document
9
Analysis of the interaction of the human immunodeficiency virus type 1 gp120 envelope glycoprotein with the gp41 transmembrane glycoprotein.
... gp120 regions without globally disrupting the gp120 conforma- tion suggests that the N and C termini of gp120 are somewhat exposed, flexible ...gp120 glycoprotein while overall conformation and, in some ... See full document
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Independent Evolution of Human Immunodeficiency Virus Type 1 env V1/V2 and V4/V5 Hypervariable Regions during Chronic Infection
... day 1 and day 240 plasma from subject ...V1/V2 sequence. Sequence differences depicted are relative to predominant V1/V2 and V4/V5 sequence populations at day ... See full document
5
Analysis of the cleavage site of the human immunodeficiency virus type 1 glycoprotein: requirement of precursor cleavage for glycoprotein incorporation.
... consensus sequence, several cellular proteases have been identified that could be responsible for the cleavage of retroviral glycoproteins ...from human cells, the product of which is known as furin (13, ... See full document
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