[PDF] Top 20 HLA-Associated Viral Mutations Are Common in Human Immunodeficiency Virus Type 1 Elite Controllers
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HLA-Associated Viral Mutations Are Common in Human Immunodeficiency Virus Type 1 Elite Controllers
... reduced viral replication capacity by HLA-B57 CTL escape mutations and recovery by putative compensatory mutations that occur outside of epitopes sup- port this explanation (6, ... See full document
7
Evidence of CD8+ T-Cell-Mediated Selective Pressure on Human Immunodeficiency Virus Type 1 nef in HLA-B*57+ Elite Suppressors
... control viral replication in light of these escape ...escape mutations in HIV-1, there are few instances where the development of escape mutations has been temporally associated with a ... See full document
10
Central Role of Reverting Mutations in HLA Associations with Human Immunodeficiency Virus Set Point
... escape mutations that inflict a fitness cost upon the virus and that therefore revert ...Specifically, HLA class I associations with the viral set point that have previously been described are ... See full document
12
Common Themes of Antibody Maturation to Simian Immunodeficiency Virus, Simian-Human Immunodeficiency Virus, and Human Immunodeficiency Virus Type 1 Infections
... of virus-specific immune responses to human immunodeficiency virus type 1 (HIV-1) and simian immunodeficiency virus (SIV) is important to understanding the ... See full document
8
Protective HLA Class I Alleles That Restrict Acute-Phase CD8+ T-Cell Responses Are Associated with Viral Escape Mutations Located in Highly Conserved Regions of Human Immunodeficiency Virus Type 1
... 76 HLA-associ- ated polymorphisms located at 47 distinct amino acid residues across HIV-1 (see Table S2 in the supplemental ...These HLA-associated mutations were then categorized into ... See full document
11
HLA Class I-Driven Evolution of Human Immunodeficiency Virus Type 1 Subtype C Proteome: Immune Escape and Viral Load
... other viral proteins in eliciting suppressive, if not protective, immunological ...costs associated with immune ...was associated with lower viral loads (36), and Gag p24 has been reported to ... See full document
13
Consistent Viral Evolutionary Changes Associated with the Progression of Human Immunodeficiency Virus Type 1 Infection
... of viral evolutionary change and X4 viruses. Mutations predictive of the X4 viral phenotype (basic amino acid substitutions at positions 306, 319, and 320 of the mature gp120 protein) were detected ... See full document
14
Quantification of the Effects on Viral DNA Synthesis of Reverse Transcriptase Mutations Conferring Human Immunodeficiency Virus Type 1 Resistance to Nucleoside Analogues
... T215Y mutations could be detected either in endogenous RT reactions or following infection of unpre- treated P4 ...T215Y mutations was clearly de- layed following infection of hydroxyurea-pretreated ... See full document
11
Unusual Distribution of Mutations Associated with Serial Bottleneck Passages of Human Immunodeficiency Virus Type 1
... 12 mutations per genome (range, 10 to 15), with a predominance of transitions (75% of all mutations) over ...of mutations accompanying Mul- ler’s ratchet in the FMDV genome—an average of six muta- ... See full document
7
Reduced Viral Replication Capacity of Human Immunodeficiency Virus Type 1 Subtype C Caused by Cytotoxic-T-Lymphocyte Escape Mutations in HLA-B57 Epitopes of Capsid Protein
... a viral relative fitness cost (21, 22, 33, 36, 37, 42, 44) raises the possibility that with sufficient understanding of the mechanisms and dynamics of the process, it may be possible to anticipate, mitigate, and ... See full document
9
Human Immunodeficiency Virus Type 1 Monoclonal Antibodies Suppress Acute Simian-Human Immunodeficiency Virus Viremia and Limit Seeding of Cell-Associated Viral Reservoirs
... of human antibod- ies in HIV-1 ...against human antibodies preclude prolonged antibody activity in ...ploying mutations to increase neonatal Fc receptor (FcRn) bind- ing and persistence in ... See full document
12
Effects of Random Mutations in the Human Immunodeficiency Virus Type 1 Transcriptional Promoter on Viral Fitness in Different Host Cell Environments
... stomatitis virus (54), Escherichia coli (16), and Aspergillus niger ...a common feature of regulatory regions requires further analysis and may for instance depend on the complexity of the tran- scriptional ... See full document
8
Maternal Transmission of Human Immunodeficiency Virus Escape Mutations Subverts HLA-B57 Immunodominance but Facilitates Viral Control in the Haploidentical Infant
... escape mutations from B57- positive ...B57-escape mutations in instances where the mother and child shared expression of ...acid mutations were present in 11 of the 16 B57-re- stricted epitopes, with ... See full document
12
Specific, sensitive, and rapid assay for human immunodeficiency virus type 1 pol mutations associated with resistance to zidovudine and didanosine
... of human immunodeficiency virus type 1 (HIV-1) disease pro- gression (3, 4, 27); however, their effects appear to be of lim- ited duration (2, ...antiretro- viral agent ... See full document
6
The Fitness Cost of Mutations Associated with Human Immunodeficiency Virus Type 1 Drug Resistance Is Modulated by Mutational Interactions
... typically associated with the reversion and loss of resistance mutations (3, 9, ...of mutations have been documented in vivo and have usually been explained by the impact of mutations on ... See full document
5
Evolution of CXCR4-Using Human Immunodeficiency Virus Type 1 SF162 Is Associated with Two Unique Envelope Mutations
... CCR5-using human immunodeficiency virus type 1 (HIV-1) isolates typically gain CXCR4 use via multiple mutations in V3 and often V1/V2 regions of envelope, and patterns of ... See full document
5
Genetic Characterization of Human Immunodeficiency Virus Type 1 in Elite Controllers: Lack of Gross Genetic Defects or Common Amino Acid Changes
... EC viral sequences were compared to viral sequences obtained from 96 CP from the greater Boston area (87 to 96 CP [complete fragments were obtained from 70 to 87 CP], depending on HIV genes) (28 and ... See full document
9
HLA-B57/B*5801 Human Immunodeficiency Virus Type 1 Elite Controllers Select for Rare Gag Variants Associated with Reduced Viral Replication Capacity and Strong Cytotoxic T-Lymphotye Recognition
... the mutations described here impact VRC might be mediated through interactions with cy- clophilin A (8, ...the virus more dependent on cyclophilin A ...compensatory mutations in the cyclophilin A ... See full document
14
HLA-Associated Alterations in Replication Capacity of Chimeric NL4-3 Viruses Carrying gag-protease from Elite Controllers of Human Immunodeficiency Virus Type 1
... Gag mutations associated with reduced VRC, 207D and 483Q, were present in only two EC and four EC, ...B virus sequences, and there are substantial mismatches within this region between clade B and ... See full document
10
The presence of host-derived HLA-DR1 on human immunodeficiency virus type 1 increases viral infectivity.
... Human immunodeficiency virus type 1 (HIV-1) incorporates several host cell components when budding out of the infected ...the HLA-DR determinant of the major ... See full document
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