[PDF] Top 20 DNA-binding activity of simian virus 40 large T antigen correlates with a distinct phosphorylation state.
Has 10000 "DNA-binding activity of simian virus 40 large T antigen correlates with a distinct phosphorylation state." found on our website. Below are the top 20 most common "DNA-binding activity of simian virus 40 large T antigen correlates with a distinct phosphorylation state.".
DNA-binding activity of simian virus 40 large T antigen correlates with a distinct phosphorylation state.
... i They clearly show the relationship between different subclasses, i.e., the DNAbinding, monomeric nuclear high-salt fractions on one hand and the nonbinding, oligomeric fractions on the[r] ... See full document
12
Nonspecific DNA binding activity of simian virus 40 large T antigen: evidence for the cooperation of two regions for full activity.
... Second, wild-type T antigen's nonspecific DNA binding, but not its origin binding, was significantly inhibited with a number of monoclonal antibodies PAb1O4, PAb114, PAb252, PAb4O2, PAb4[r] ... See full document
10
Simian Virus 40 Large T Antigen Disrupts Genome Integrity and Activates a DNA Damage Response via Bub1 Binding
... mimics DNA damage or that ATR acts upstream to phosphor- ylate ATM on Ser1981 ...cellular DNA replication dynamics, for example, rereplication or increased replication fork stall- ing, and this is sensed as ... See full document
11
Simian virus 40 large T antigen alters the phosphorylation state of the RB-related proteins p130 and p107.
... cycle-dependent phosphorylation, form complexes with the E2F family of tran- scription factors, and associate with oncoproteins of DNA tumor viruses, including simian virus 40 (SV40) ... See full document
8
Characterization of the DNA-Binding Properties of the Origin-Binding Domain of Simian Virus 40 Large T Antigen by Fluorescence Anisotropy
... the T-antigen OBD would in- crease substantially its affinity for DNA, as we have observed for the related DBD of the papillomavirus E1 helicase ...the T- antigen OBD would indeed ... See full document
7
Role of Single-Stranded DNA Binding Activity of T Antigen in Simian Virus 40 DNA Replication
... single-stranded DNA binding domain of large T antigen to amino acid residues 259 to ...this binding activity, a series of single-point substitutions were introduced in ... See full document
9
Dimerization of simian virus 40 T-antigen hexamers activates T-antigen DNA helicase activity.
... comparing T-antigen binding to the DNA fork and DNA bubble, reaction mixtures containing ...the DNA fork or bubble substrates, 700 ng of T antigen, ...duplex ... See full document
8
Mechanisms of simian virus 40 T-antigen activation by phosphorylation of threonine 124.
... whether phosphorylation of Thr-124 might en- hance assembly of high-order complexes of T1-259 on core origin DNA even in the absence of hexamer ...origin DNA and T1-259 without and with ...of ... See full document
7
Simian virus 40 small t antigen activates the carboxyl-terminal transforming p53-binding domain of large T antigen.
... small t is able to mediate, in cooperation with large T, metabolic stabi- lization of p53 in complex with large ...Small t is a transacti- vator of polymerase II and III promoters (5, ... See full document
9
Improved localization of phosphorylation sites in simian virus 40 large T antigen.
... Amino acid sequence analysis of fragments generated by partial proteolysis from large simian virus 40 tumor antigen.. Binding of dephosphorylated A protein to SV40 DNA.[r] ... See full document
17
Oligomerization and origin DNA-binding activity of simian virus 40 large T antigen.
... In contrast, studies carried out with lytic T-antigen subclasses separated by zone velocity sedimentation or phosphocellulose chromatography showed that newly synthesized 5 to 7S T antig[r] ... See full document
8
Identification of simian virus 40 T-antigen residues important for specific and nonspecific binding to DNA and for helicase activity.
... 4858 Downloaded from http://jvi.asm.org/ on November 10, 2019 by guest We have previously identified three regions called elements in the DNA-binding domain of simian virus 40 large tumo[r] ... See full document
8
Multiple DNA Damage Signaling and Repair Pathways Deregulated by Simian Virus 40 Large T Antigen
... of simian virus 40 (SV40) large T antigen (LT), without a viral origin, is sufficient to induce the hallmarks of a cellular DNA damage response (DDR), such as focal ... See full document
14
Quantitative Analysis of the Binding of Simian Virus 40 Large T Antigen to DNA
... Eukaryotic DNA replication is a complex process that is initiated by the coordinated action of several factors, including the origin recognition complex, cdt1, cdc6, and the minichro- mosome maintenance complex, ... See full document
13
Effects of in vitro dephosphorylation on DNA-binding and DNA helicase activities of simian virus 40 large tumor antigen.
... 22 showed that dephosphorylation by alkaline phosphatase increases the affinity of T antigen to the SV40 binding site II and, furthermore, that the activity of dephosphorylated T antigen[r] ... See full document
8
Phosphorylation downregulates the DNA-binding activity of simian virus 40 T antigen.
... 888 Downloaded from http://jvi.asm.org/ on November 10, 2019 by guest Proteolytic fragments of simian virus 40 tumor T antigen and T antigen that was dephosphorylated with alkaline phosp[r] ... See full document
7
The finger domain of simian virus 40 large T antigen controls DNA-binding specificity.
... Mutations in the phosphorylation sites of simian virus 40 SV40 T antigen alter its origin DNA-binding specificity for sites I and II and affect SV40 DNA replication activity.. Initiation[r] ... See full document
6
Mutations in the phosphorylation sites of simian virus 40 (SV40) T antigen alter its origin DNA-binding specificity for sites I or II and affect SV40 DNA replication activity.
... 5 0022-538X/88/051598-08$02.00/0 Copyright © 1988, American Society for Microbiology Mutations in the Phosphorylation Sites of Simian Virus 40 SV40 T Antigen Alter Its Origin DNA-Binding[r] ... See full document
8
Differential phosphorylation of cytoplasmic and nuclear variants of simian virus 40 large T antigen encoded by simian virus 40-adenovirus 7 hybrid viruses.
... 636 Downloaded from http://jvi.asm.org/ on November 10, 2019 by guest The phosphorylation patterns of cytoplasmic and nuclear forms of simian virus 40 large T antigen encoded by simian v[r] ... See full document
5
Four major sequence elements of simian virus 40 large T antigen coordinate its specific and nonspecific DNA binding.
... By testing the effects of single-site mutations on virus replication and by performing a number of DNA-binding assays on replication-negative T-antigen mutants, we have identified severa[r] ... See full document
11
Related subjects