[PDF] Top 20 Clinical Control of HIV-1 by Cytotoxic T Cells Specific for Multiple Conserved Epitopes
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Clinical Control of HIV-1 by Cytotoxic T Cells Specific for Multiple Conserved Epitopes
... of specific CTL responses since such longer peptides hardly induce the specific ...imal epitopes to precisely clarify the ability of HIV-1-specific CTLs to control of ... See full document
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Cytotoxic T cell responses to multiple conserved HIV epitopes in HIV resistant prostitutes in Nairobi
... of HIV-1 infection (MacDonald, ...efficient HIV-specific CTL responses or present epitopes, which are highly conserved between HIV-1 ...CTL epitopes ... See full document
9
Cross-Reactivity against Multiple HIV-1 Epitopes Is Characteristic of HIV-1-Specific Cytotoxic T Lymphocyte Clones
... heterologous epitopes is be- lieved to exist for cellular immunity, limited data explore this issue for human immu- nodeficiency virus type 1 (HIV-1)-specific CD8 ⫹ T lymphocyte (CTL) ... See full document
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Effective Suppression of HIV-1 Replication by Cytotoxic T Lymphocytes Specific for Pol Epitopes in Conserved Mosaic Vaccine Immunogens
... protective epitopes we have identified in the tHIVconsvX immunogens play an impor- tant role in immunity against HIV-1 clade B infection in ...of T-cell responses to 18-mer overlapping ... See full document
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Superior Control of HIV-1 Replication by CD8+ T Cells Targeting Conserved Epitopes: Implications for HIV Vaccine Design
... of clinical progression is highly ...+ T cells in HIV ...+ T cells [15–17] supports the view that this arm of immune system is applying pressure on the ...that T ... See full document
13
CD8+ T cells specific for conserved, cross reactive Gag epitopes with strong ability to suppress HIV 1 replication
... + T-cells because of their strong contri- bution to favorable clinical ...optimal epitopes and their HLA restriction, which were recognized by CD8 + T cells specific for ... See full document
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Immunogenicity of a Human Immunodeficiency Virus (HIV) Polytope Vaccine Containing Multiple HLA A2 HIV CD8+ Cytotoxic T-Cell Epitopes
... of HIV-infected individuals (H28, H10, H19, H21, and H33) used as effectors against (i) HLA A21 LCLs sensitized with the indicated peptide (black squares) or not sensitized (white squares) (columns headed ... See full document
6
Differential Neutralization of Human Immunodeficiency Virus (HIV) Replication in Autologous CD4 T Cells by HIV-Specific Cytotoxic T Lymphocytes
... uninfected cells com- pared with CTL recognition of virus-infected ...clone specific for a relatively conserved epitope in gp41 (18), indicating that ineffective inhibition of virus repli- cation is ... See full document
12
Broad Recognition of Circulating HIV-1 by HIV-1-Specific Cytotoxic T-Lymphocytes with Strong Ability to Suppress HIV-1 Replication
... AIDS Clinical Center, National Center for Global Health and Medicine, Tokyo, Japan ABSTRACT HIV-1-specific cytotoxic T-lymphocytes (CTLs) with strong abilities to suppress ... See full document
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Insights into the Cytotoxic Potential of Human CD8+ T Cells: Implications for Virologic Control of HIV
... HCMV epitopes, displayed a differential ability to upregulate ...responding cells to upregulate perforin, whereas the SL12 peptide induced 53% of IFN-γ producing cells to express ...activated ... See full document
166
HIV-specific CD8 + T cells and HIV eradication
... + T cells against the viral reservoir that persists in the setting of cART (Figure ...achieving HIV eradication, we do, however, draw considerable inspiration from the other precedents that ... See full document
10
HIV specific CD8+ T cells and HIV eradication
... + T cells against the viral reservoir that persists in the setting of cART (Figure ...achieving HIV eradication, we do, however, draw considerable inspiration from the other precedents that ... See full document
10
Enhanced Detection of Human Immunodeficiency Virus Type 1 (HIV-1) Nef-Specific T Cells Recognizing Multiple Variants in Early HIV-1 Infection
... subjects’ T cells recognized the highest ranking peptides, and few recognized the low-ranking ...most conserved among the different virus ...highly conserved, do not contain T-cell ... See full document
13
Identification of new HIV 1 Gag specific cytotoxic T lymphocyte responses in BALB/c mice
... As HIV-specific cytotoxic T cells play a key role during acute and chronic HIV-1 infection in humans, the ability of potential anti-HIV vaccines to elicit strong, ... See full document
7
High-Functional-Avidity Cytotoxic T Lymphocyte Responses to HLA-B-Restricted Gag-Derived Epitopes Associated with Relative HIV Control
... Gag-derived epitopes in antiviral immunity (4, 6, 16, 38, 42, 44, ...presented epitopes in the context of HLA-B alleles. The HLA-B-restricted HIV epitope repertoire is thought to be enriched for ... See full document
12
HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes
... ⫹ T-cell targeting as a causal mechanism behind HLA-medi- ated control (reviewed in reference 4), it has been difficult to prove this ...immunodominant epitopes by the protective B27 (69–72), B57 ... See full document
12
Cooperativity of HIV-Specific Cytolytic CD4 T Cells and CD8 T Cells in Control of HIV Viremia
... ⴙ T cells play a pivotal role in the control of chronic viral ...ⴙ T cell functions beyond helper effects have been described, and a role for cytolytic CD4 ⴙ T cells in the ... See full document
12
Selection and Accumulation of an HIV-1 Escape Mutant by Three Types of HIV-1-Specific Cytotoxic T Lymphocytes Recognizing Wild-Type and/or Escape Mutant Epitopes
... virus-infected cells and suppressed the replication of the WT vi- rus, whereas they exhibited no and weak ability, respectively, to suppress that of the 3R ...least 1 year after Gag28-specific CTLs ... See full document
11
Control of HIV-1 Pathogenesis in Viremic Nonprogressors Is Independent of Gag-Specific Cytotoxic T Lymphocyte Responses
... IMPORTANCE Control of HIV infection has been widely studied in elite controllers or long-term nonprogressor ...⫹ T cell counts despite high plasma ...remarkable control of HIV-1 ... See full document
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Strong Ability of Nef-Specific CD4+ Cytotoxic T Cells To Suppress Human Immunodeficiency Virus Type 1 (HIV-1) Replication in HIV-1-Infected CD4+ T Cells and Macrophages
... Nef epitopes as HLA-DR re- stricted in our ...II-restricted epitopes are processed through the exogenous ...⫹ T-cell recognition of virus-infected cells, the endogenous pathway for HLA class ... See full document
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