[PDF] Top 20 Combining multiple family based association studies
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Combining multiple family based association studies
... two studies achieved statistical sig- nificance, even though the latter procedure has an inflated type I ...therefore combining across studies will achieve even greater ...both studies and the ... See full document
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Implicit Hypotheses Are Hidden Power Droppers in Family Based Association Studies of Secondary Outcomes
... Although developed to handle a large variety of tests according to the nature of both the traits and their ge- netic determinants, it is intrinsically designed to test primary outcomes (e.g. affected vs. unaffected) as ... See full document
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Accounting for relatedness in family based association studies: application to Genetic Analysis Workshop 18 data
... one based on the Balding-Nichols method [4]; (b) FaST-LMM [5], which also implements 2 methods to adjust for related- ness: one using a standard covariance matrix and one using the realized relationship matrix; ... See full document
5
Association between multiple sclerosis and epilepsy: large population-based record-linkage studies
... is based on hospital admissions, it is possible that some people will have had clinical MS, and some will have had epilepsy, without being admitted to hospital; and others will have had admissions for either ... See full document
6
Logistic Bayesian LASSO for detecting association combining family and case control data
... is based on an MCMC proced- ure to sample from the posterior distribution, it is com- putationally intensive, and thus not suitable for whole-genome ...a family-based single-SNP association ... See full document
5
On family based genome wide association studies with large pedigrees: observations and recommendations
... and family- based association testing (FBAT) are 2 broad strategies to examine family-based association in the context of large extended ...extended family data is ... See full document
5
A comparison of whole genome sequencing with exome sequencing for family based association studies
... genome-wide association studies (GWAS) have successfully identified thousands of genetic loci associated with a variety of diseases and phenotype traits ... See full document
6
A 2 step penalized regression method for family based next generation sequencing association studies
... We chose to use a kinship matrix estimated based on genomic data to adjust for family structure because this confers several advantages over pedigree kinship [1,4,6]. First, it does not depend on the ... See full document
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Coping with family structure in genome wide association studies: a comparative evaluation
... study, family structures provide additional information on potential de- pendence among ...the family structure [the Z in ...is based on the ... See full document
6
Analytical Tools for Population-based Association Studies
... haplotype based test is better than the single marker based ...haplotype-based association tests have greater power when SNPs are in strong linkage disequilibrium with the disease locus (Akey ... See full document
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A two step multiple marker strategy for genome wide association studies
... To evaluate the performance of our strategy, we first iden- tified, in each replicate, the true positive and the true neg- ative regions among those selected in Step 1, a region being defined as positive if it contained ... See full document
7
Combining estimates of interest in prognostic modelling studies after multiple imputation: current practice and guidelines
... Background: Multiple imputation (MI) provides an effective approach to handle missing covariate data within prognostic modelling studies, as it can properly account for the missing data ...for ... See full document
8
Statistical adjustment of genotyping error in a case–control study of childhood leukaemia
... of multiple misclassified vari- ables, takes account of the size of the validation sample, and does not require the validation sample to include ...genetic association studies based on cases ... See full document
8
A Simple Scalable Association Hypothesis Test Combining Gene-wide Evidence from Multiple Polymorphisms
... summing association statistics in order of statistical significance, deflating the remaining marker-level statistic at every step, based on their correlation with the statistics for the markers already ... See full document
10
Combining information from linkage and association mapping for next generation sequencing longitudinal family data
... In this article, we investigate the contribution that link- age-based methods, such as IBD mapping, can make to association mapping to identify rare variants in next- generation sequencing data. In the ... See full document
5
Association between social and family support and antenatal depression: a hospital based study in Chengdu, China
... previous studies, employment and higher educational level of pregnant women were related to the AD prevalence ...in family support and cognition aspects among pregnant ... See full document
10
Combining education and family life
... In these circumstances a course was selected because, for example, it had government funding attached or fees were paid by their employer. ‘Exploratory’ learners (all studying in FE) reported an added incentive for doing ... See full document
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A general method for combining different family based rare variant tests of association to improve power and robustness of a wide range of genetic architectures
... of association; the additional noise from this correlation diminishes the power of the combined test to detect any meaningful genotype–phenotype associa- ...if combining tests with known asymptotic ... See full document
6
Associating Multivariate Quantitative Phenotypes with Genetic Variants in Family Samples with a Novel Kernel Machine Regression Method
... in association studies of complex traits (Falk and Rubinstein 1987; Ott 1989; Terwilliger and Ott 1992; Spielman et ...in family-based studies if familial correlation is ...In ... See full document
14
Use of principal components to aggregate rare variants in case control and family based association studies in the presence of multiple covariates
... case-control studies and one for family-based studies) that combine aggregated rare variants and common variants located within a region through principal components analysis and allow for ... See full document
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