[PDF] Top 20 Control of Herpes Simplex Virus Replication Is Mediated through an Interferon Regulatory Factor 3-Dependent Pathway
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Control of Herpes Simplex Virus Replication Is Mediated through an Interferon Regulatory Factor 3-Dependent Pathway
... transcription through cog- nate binding sites on the IFN-  promoter ...to control and IRF-3 ⫺/⫺ mice, but no increases in virus titers were observed in IRF-3- or IRF-7-deficient cells ... See full document
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The Neuronal Host Cell Factor-Binding Protein Zhangfei Inhibits Herpes Simplex Virus Replication
... negative control we stained a parallel array with the anti-Zhangfei serum from which most of the antibodies against Zhangfei had been removed by absorp- tion to recombinant ... See full document
11
Interferon Regulatory Factor 3-Dependent Pathways Are Critical for Control of Herpes Simplex Virus Type 1 Central Nervous System Infection
... HSV-1 replication may not be so ...tight control of IRF-3 activation by HSV during infection so that IRF-3-deficiency has little ...live virus (9, 33, ... See full document
10
Epstein-Barr Virus BGLF4 Kinase Suppresses the Interferon Regulatory Factor 3 Signaling Pathway
... Gal4-IRF3 (Fig. 6B), which contains aa 57 to 427 of IRF3, in a Gal4-IRF3 reporter system, the involvement of Thr3 in BGLF4 kinase activity-dependent repression may be excluded (Fig. 6B). Additionally, Ser339 of ... See full document
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Neurotropic Arboviruses Induce Interferon Regulatory Factor 3-Mediated Neuronal Responses That Are Cytoprotective, Interferon Independent, and Inhibited by Western Equine Encephalitis Virus Capsid
... responses mediated by the transcription factor IRF-3 have multiple functions in the control of viral ...viral replication through the activation of antiviral genes such as PKR, ... See full document
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Gamma Interferon-Induced Interferon Regulatory Factor 1-Dependent Antiviral Response Inhibits Vaccinia Virus Replication in Mouse but Not Human Fibroblasts
... VACV replication (33, ...VACV replication in this ...the factor responsible for inhibiting VACV replication is induced only by IFN- ␥ and independent of type I ...to control myxoma ... See full document
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Role of Interferon Regulatory Factor 3-Mediated Apoptosis in the Establishment and Maintenance of Persistent Infection by Sendai Virus
... or virus infection caused effective degradation of IRF-3 in these ...the pathway in check by inhibiting apoptosome assem- bly; at later times in infection, it is degraded and the brake is released to ... See full document
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Differential Effect of Murine Alpha/Beta Interferon Transgenes on Antagonization of Herpes Simplex Virus Type 1 Replication
... initiation factor 2␣, resulting in the inhibition of protein synthesis (46, ...progeny virus. However, IFN-␣/ pro- mote apoptosis (4) through a PKR-mediated pathway (69) and therefore ... See full document
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Δγ134.5 Herpes Simplex Viruses Encoding Human Cytomegalovirus IRS1 or TRS1 Induce Interferon Regulatory Factor 3 Phosphorylation and an Interferon-Stimulated Gene Response
... IFN regulatory factor 3 (IRF3) by tank binding kinase 1 (TBK1) (14, ...(STAT) pathway, resulting in IRF3- and IRF7-mediated ISG and IFN- ␣ gene ...viral replication and spread ... See full document
5
Herpes Simplex Virus 1 UL36USP Antagonizes Type I Interferon-Mediated Antiviral Innate Immunity
... To determine whether UL36USP affected IFN-  -induced transcription of ISGs during HSV-1 infection, we constructed the UL36USP stable-knockdown HEK293T cells. Three different small hairpin RNAs specific for UL36USP ... See full document
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Replication-Competent Controlled Herpes Simplex Virus
... phase 3 study on melanoma patients revealed a statistically significant better response to intralesional injection of T-VEC than to control treatment (subcutaneous granulocyte-macrophage colony-stimulating ... See full document
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Activation of Interferon Response Factor-3 in Human Cells Infected with Herpes Simplex Virus Type 1 or Human Cytomegalovirus
... cellular interferon-stimulated genes (ISGs) after infection with herpes simplex virus type 1 (HSV-1) or human cytomegalovirus (HCMV) was ...either virus in the presence of ...of ... See full document
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Selective Editing of Herpes Simplex Virus 1 Enables Interferon Induction and Viral Replication That Destroy Malignant Cells
... initiation factor eIF2 ␣ ( ␣ subunit of eukaryotic initiation factor 2), ensuring viral protein ...(IFN) regulatory factor 3 (IRF3) and IFN expression, known to prime immunity against ... See full document
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Herpes Simplex Virus 1 Serine Protease VP24 Blocks the DNA-Sensing Signal Pathway by Abrogating Activation of Interferon Regulatory Factor 3
... signal pathway is the first line of host innate defense against viral infection, and it is responsible for the induc- tion of numerous ...signal pathway is activated upon recognition of viral nucleic acids ... See full document
6
West Nile Virus Evades Activation of Interferon Regulatory Factor 3 through RIG-I-Dependent and -Independent Pathways without Antagonizing Host Defense Signaling
... WNV-NY replication. Ablation of the RIG-I pathway resulted in an increase in WNV-NY titers and CPE in MEFs, demonstrating enhanced viral repli- ...RIG-I pathway contrib- utes to the establishment of ... See full document
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A role for DNA-dependent activator of interferon regulatory factor in the recognition of herpes simplex virus type 1 by glial cells
... We and others have demonstrated that microglia and astrocytes express an array of cell surface and endosomal innate pattern recognition receptors, including TLR2 [9,21], TLR3 [49,50], TLR7 [50], and TLR9 [50], that are ... See full document
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Critical Role for Interferon Regulatory Factor 3 (IRF-3) and IRF-7 in Type I Interferon-Mediated Control of Murine Norovirus Replication
... signaling through the IFN-␣/R, in- duce an antiviral response that limits dissemination of MNV and/or the replication of the virus in extraintestinal ...MNV replication at primary sites of ... See full document
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Independent and Cooperative Antiviral Actions of Beta Interferon and Gamma Interferon against Herpes Simplex Virus Replication in Primary Human Fibroblasts
... the replication of a variety of viruses, including herpes simplex virus ...DNA replication significantly more than treatment with either interferon ...HSV-1 replication in ... See full document
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Activation of Interferon Regulatory Factor 3 Is Inhibited by the Influenza A Virus NS1 Protein
... Expression plasmids. pCAGGS-NS1(SAM) and pCAGGS-NS1-R38AK41A (SAM) contain the open reading frame of NS1 from wild-type influenza A (PR8) virus in an expression vector containing a chicken -actin promotor ... See full document
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Protective Role of Interferon Regulatory Factor 3-Mediated Signaling against Prion Infection
... initiated through both Toll-like receptors (TLRs) (2) and intracellular sensor mol- ecules such as retinoic acid inducible gene-I (RIG-I) and mela- noma differentiation-associated gene-5 (MDA5), each of which ... See full document
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