[PDF] Top 20 The development of polycationic materials for gene delivery applications

... Further delivery enhancement has been achieved in the presence of targeting ligands, endosomolytic compounds, and nuclear localizing ...In polycationic materials there is also nonspecific binding via ... See full document

... acid delivery. Furthermore, traditional drug-delivery systems still face problems with drug side effects, efficacy, and patient ...drug delivery. Utilizing nanotechnology has led to the ... See full document

... We use self-consistent field theory to study the thermodynamics of membrane-particle interactions in the context of polymer-based gene delivery systems. Our aim is to guide the design of dendrimers that can ... See full document

... and delivery properties of biopolymer derivatives ...the development of stimulus‐responsive DDSs in ILs, the incorporation of stimulus‐sensitive polymer units into the biopolymer is an easy way to combine ... See full document

... The delivery of genes at targeted site is still a formidable ...Genetic materials are labile to the biological environment as well as they don’t cross the biological membranes ...Conventionally gene ... See full document

... nonviral delivery of siRNAs by polycationic polymers to the lung (Thomas et al ...siRNA delivery (Thomas et al 2005; Grayson et al 2006; Werth et al ...vaccine development studies have shown ... See full document

... Although much progress has been made in various areas of graphene research, much work remains to develop appli- cations for human welfare. Graphene and its derivatives show potential toxicity in biological systems ... See full document

... Non-viral gene delivery mediated artificially by phys- ical method uses to introduce genetic materials through the cell ...of gene deliv- ery includes needle injection, ballistic DNA ... See full document

... develop materials with improved controllability and specificity, we have investigated synthesis of composite hydrogels with temperature-sensitive properties using thermal cross-linking, Specifically in the ... See full document

... alternative gene delivery vectors ...as gene carriers include low cytotoxicity and high transfection ...of polycationic micelles as gene delivery vectors represents the new ... See full document

... Anionic liposomes composed of EPC:NaO (10:2 molar ratio) were prepared by sonication. Briefly, EPC and NaO were separately dissolved in chloroform:methanol (2:1 v/v). The materials were deposited in a test tube, ... See full document

... the delivery of a higher dose at the site-specific organs by using ligands while conferring a controlled release and degradation to non-toxic ...drug delivery and the focus of recent research concerns the ... See full document

... Hydroxyethyl cellulose is an important derivative of cellulose, which finds application in drug delivery. The highlighting properties of HEC such as, water solubility, non-ionic form , thickening agent, and can ... See full document

... There are two criteria commonly being proposed to describe the efficiency of self-emulsifying formulation: 1) the rate of emulsification and 2) the particle size distribution of the resultant emulsion. Particle size ... See full document

... For systemic therapy, the nasal route has attracted increasing attention as a suitable method for drug delivery. The nasal cavity as a site for systemic absorption of drug has some advantages which include large ... See full document

... a measure of material density as it relates to the surface electron density. As the sample and detector are translated through a predetermined angular range, where theta is increasing at a rate of 2*omega, the collimated ... See full document

... develop dosage forms with sustained-release properties. [4] Glyceryl monostearate, a waxlike solid in the form of beads, flakes, or powder, is used as a lubricant for tablet manufacturing and may be used to form ... See full document

... In an open-label, randomized, clinical trial, Graziani et al investigated the effect of the addition of intramuscular administration of neridronate (12.5 mg weekly for 3 months)[r] ... See full document

... Percentage of cumulative release of cefuroxime from both standard solution and CLN exhibited a biphasic pattern, as shown by the rapid initial release of the drug during the first 8 h, followed by a slow release for the ... See full document

... in development of new non-steroidal anti-inflammatory drugs (NSAIDs), ketoprofen remains one of the most effective ‘over-the-counter’ drugs in the treatment of rheumatoid arthritis ... See full document