[PDF] Top 20 Dynamics of Human Immunodeficiency Virus Type 1 Replication in Vertically Infected Infants

... the infants and children were studied close to the time of the acquisition of infection, their viral load and CD4 T-cell numbers were not likely to be in a steady state prior to the initiation of ...equation ... See full document

... for 1 h, 4 U of RQ1 DNase was added to digest the template ...(Molecular Dynamics), quantitated with ImageQuant and Microsoft Excel software, and exposed to Kodak XAR-5 film at 270°C for 1 to 4 ... See full document

... in infants (11, 44) who showed a rapid clinical ...remaining infants had viral isolates with a slow/low ...viral replication and the maturation status of the immune system in ...of virus ... See full document

... viral replication between HIV-1/TB-coinfected responders and nonresponders is un- clear and may relate to the duration of TB-related immune ...viral replication after successful treat- ment of ... See full document

... cells infected with ...also infected NHOKs with an efficiency approximately one-eighth of that with which they infected PBLs, although full-length viral DNA was minimal for Ba-L ...heat-inactivated ... See full document

... link between the Gag/Gag-Pol ratio and HIV-1 particle assem- bly. Stimulating frameshifting resulted in only a modest effect on overall viral gene expression (a two- to threefold change in the Gag/Gag-Pol ratio) ... See full document

... The clearance of viral infections from mammalian hosts normally requires pathogen-specific immune responses, such as neutralizing antibodies and cytotoxic T lymphocytes. How- ever, target-nonspecific or innate defenses ... See full document

... this type of ...and virus spread was assayed by measurement of the virion-associated CA-p24 levels in the culture ..., 1 m g), we consistently did not observe virus production for either ... See full document

... Human immunodeficiency virus type 1 (HIV-1) replication is initiated through interaction of the viral envelope glycopro- tein gp120 with its host cell receptor CD4 ... See full document

... the human immunodeficiency virus type 1 (HIV-1) genome into a chromosome of an infected cell is a pivotal step in virus ...the virus-encoded integrase, which ... See full document

... in three important respects. First, these data describe the probabilities to onset of neurodevelopmental im- pairments from 6 to 24 months among HIV-infected infants who were followed from birth. Second, ... See full document

... for 1 h at 37°C. The cells were treated with pronase, to eliminate virus adsorbed at the cell surface, and ...newly infected cells. P4C5 cells were preincubated for 30 min with (1) or without ... See full document

... CD4 1 T-cell count ...CD4 1 T-cell numbers (36). Moreover, changes in the splicing pattern of HIV-1 RNA have been detected in patients following administration of specific anti-HIV-1 compounds ... See full document

... with virus load in the sera of HIV-1-infected individuals have been shown (25, 60), especially in those suffering neurological com- plications ...HIV-1 replication in T ... See full document

... Marburg virus-infected cells, suggesting that Rab9 is utilized in Marburg ...in human immunodeficiency virus (HIV) replication, previous reports suggested that the late endosome ... See full document

... No depletion of CD4+ human thymocytes was observed in implants infected with either HIV-lJRCSF or its nef mutant at 3 or 6 weeks postinfection compared with controls consisting of mock-i[r] ... See full document

... both virus and host could be genetically ...HIV replication, previous work has demonstrated that this is not the ...HIV-1 replication, although these cells were able to support at least some ... See full document

... HHV-8 replication has not yet been ...some human chorionic gonadotropin preparations ...HHV-8 replication during pregnancy and underscore the need for investigations to elucidate the interplay ... See full document

... HIV-1 replication cycle was also studied using pseudotyped viruses as described ...for human HeLa cells ...of human and rat T-cell lines for expression of hCD4 and ...were infected with ... See full document

... of virus genotypes within infected individuals and as a means to track transmission of the virus between ...children infected by maternal transmission of the ...two infants at 2 d and 4 ... See full document