[PDF] Top 20 Effects of Mutations in the Human Immunodeficiency Virus Type 1 gag Gene on RNA Packaging and Recombination
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Effects of Mutations in the Human Immunodeficiency Virus Type 1 gag Gene on RNA Packaging and Recombination
... and recombination between a vector with wild- type gag and vectors with mutant ...the effects of gag mutation on replication assisted by trans-acting proteins and recombination, ... See full document
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Linker insertion mutations in the human immunodeficiency virus type 1 gag gene: effects on virion particle assembly, release, and infectivity.
... the Gag protein appear to be important in the early stages of the viral life ...insertion mutations had minimal defects in viral assembly, Env incorporation and RNA packaging, yet all had ... See full document
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Mutations in the kissing-loop hairpin of human immunodeficiency virus type 1 reduce viral infectivity as well as genomic RNA packaging and dimerization.
... genomic RNA within COS-7 cells ...that RNA recombination (22, 23, 50), plus-strand DNA initiation, and/or second-strand transfer might be affected by our muta- tions; we simply note that considerable ... See full document
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Opposing Effects of Human Immunodeficiency Virus Type 1 Matrix Mutations Support a Myristyl Switch Model of Gag Membrane Targeting
... clone, virus replication in highly permissive CEMx174 cells was blocked, and a significant replication defect was ob- served even after the conservative substitution of Leu8 for Ile (data not ...whether ... See full document
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The Conformation of the Mature Dimeric Human Immunodeficiency Virus Type 1 RNA Genome Requires Packaging of Pol Protein
... The packaging of a mature dimeric RNA genome is an essential step in human immunodeficiency virus type 1 (HIV-1) ...HIV-1 Gag-Pro-Pol precursor ... See full document
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Intrapatient sequence variation of the gag gene of human immunodeficiency virus type 1 plasma virions.
... the gag clones from that patient, it is unlikely that it arose by superinfection from a different ...viral RNA may reflect the expression of only a limited subset of integrated proviruses since this has ... See full document
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Cumulative Mutations of Ubiquitin Acceptor Sites in Human Immunodeficiency Virus Type 1 Gag Cause a Late Budding Defect
... of human immunodeficiency virus type 1 (HIV-1) Gag has long been known to be monou- ...in virus release, the relevance of Gag ubiquitination is ...of ... See full document
9
Intracellular expression of RNA transcripts complementary to the human immunodeficiency virus type 1 gag gene inhibits viral replication in human CD4+ lymphocytes.
... antisense RNA-expressing CEMSS cells (upper panel, left peak) express 10-fold-lower p24 Ag levels (mean fluorescence intensity, 50) ...HIV-1 Gag protein production in these infected ...prepared ... See full document
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A Heterologous, High-Affinity RNA Ligand for Human Immunodeficiency Virus Gag Protein Has RNA Packaging Activity
... genomic RNA dimerization (11, 23, 24, 28, 31, 32, 34, ...HIV-1 RNA dimerization (11), as well as the alternating purines and pyrimidines which occur in the SL1 loop palindromes of all ... See full document
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Inducible human immunodeficiency virus type 1 packaging cell lines.
... simplex virus VP16 protein, which can transactivate expression from the inducible ...the packaging cell line consti- tutively express tTA (15). The gene of interest of the second construct is ... See full document
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Analysis of Human Immunodeficiency Virus Type 1 Gag Dimerization-Induced Assembly
... HIV-1 Gag assembly (18, 31) ...RSV Gag protein dimers do not self-assemble at pH ...HIV-1 Gag assembly in vitro (8, 9, 13, ...temperature effects were observed with our ... See full document
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Mutational analysis of cis-acting packaging signals in human immunodeficiency virus type 1 RNA.
... To determine whether sequences that we had previously demonstrated to be important for binding of HIV-1 RNA to the HIV-1 Gag polyprotein in vitro 9, 35 were necessary for packaging of RN[r] ... See full document
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Maintenance of the Gag/Gag-Pol Ratio Is Important for Human Immunodeficiency Virus Type 1 RNA Dimerization and Viral Infectivity
... virion RNA packaging. For virion RNA analysis, HxB2-BH10 proviral DNA was replaced with ⌬Rev proviral DNA in a ...the Gag-Pol- expressing vector was supplemented in the virus-producing ... See full document
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Mechanisms of Human Immunodeficiency Virus Type 2 RNA Packaging: Efficient trans Packaging and Selection of RNA Copackaging Partners
... Human immunodeficiency virus type 2 (HIV-2) has been reported to have a distinct RNA packaging mechanism, referred to as cis packaging, in which Gag proteins ... See full document
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Multiple effects of mutations in human immunodeficiency virus type 1 integrase on viral replication.
... and virus stocks were produced by transfecting HeLa or 293 ...of virus released into cell supernatants was assayed in the human T-cell leukemia line CEM-12D7 ...-galactosidase gene under the ... See full document
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Effects of nucleocapsid mutations on human immunodeficiency virus assembly and RNA encapsidation.
... wt Gag but produces immature virions, since pol gene products are not ...the gag ORF to terminate at different posi- tions in p2 or NC and eliminate pol ORF ...normal type, oligonucleotides ... See full document
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Nucleocapsid and Matrix Protein Contributions to Selective Human Immunodeficiency Virus Type 1 Genomic RNA Packaging
... of RNA incorporation by mutant viruses relative to the parental wild type, the intensity of a band corresponding to amplified genomic RNA from mutated viruses was compared to the intensity of bands ... See full document
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RNA Structure and Packaging Signals in the 5′ Leader Region of the Human Immunodeficiency Virus Type 1 Genome
... target RNA into HIV-1 virions ...mous packaging activity spans the first 350 to 400 contiguous bases of the genome, and thus includes not only SL1 to SL4 but also 242 bases upstream (22, 25, 31, ... See full document
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Cytoplasmic Utilization of Human Immunodeficiency Virus Type 1 Genomic RNA Is Not Dependent on a Nuclear Interaction with Gag
... and gag/gag-pol expression plasmids containing the MA substitution mirrored the data ob- tained with the nonmutated counterparts ...mutant Gag was not able to pro- mote packaging without Rev ... See full document
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Influence of gag on Human Immunodeficiency Virus Type 1 Species-Specific Tropism
... CypA gene knocked out is unable to replicate HIV-1 ...opposite effects of CSA in humans and monkeys are due to differences between Ref1 and ...the human population, whereas this acquisition ... See full document
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