[PDF] Top 20 Formulation and Evaluation of Gastroretentive Floating Microspheres of Lafutidine

... Lafutidine floating microspheres were successfully prepared by Ionotropic gelation method using Sodium alginate, HPMC K4M and Ethyl cellulose as polymers, sodium bicarbonate as gas generating agent ... See full document

... evaluate floating drug delivery system of Lafutidine; a novel H2 receptor ...The floating tablets of Lafutidine were prepared by low density and effervescent technique using HPMC K15M, Bees ... See full document

... is Lafutidine 10 mg, two times in Day, due to its selective absorption from upper part of ...gastro-retentive floating beads of the Lafutidine were developed to increase the gastric residence time of ... See full document

... ¾ Shah S.H. et. al., (2005) Technological attempts have been made in the research and development of rate-controlled oral drug delivery systems to overcome physiological adversities, such as short gastric residence times ... See full document

... absorption. Floating microspheres are prepared with enteric coated polymer (sodium alginate) [successfully by the solvent evaporation ...of microspheres, the amount of drug released from ... See full document

... Gastroretentive floating tablets of lafutidine were prepared by wet granulation technique using different concentrations of Gum Kondagagu, Gum olibanum and Locust bean ... See full document

... short floating lag time together with prolonged ...desired formulation to provide good buoyancy with floating lag time less than a ...higher floating duration because of constant generation ... See full document

... a gastroretentive drug delivery system. Floating tablets of Tinidazole were prepared by employing two different grades of HPMC K4M and HPMC E15M in different concentrations by effervescent granulation ... See full document

... biodegradable microspheres incorporating a drug dispersed or dissolved throughout particle matrix have the potential for controlled release of ...drugs. Floating microspheres have emerged as an ... See full document

... Glipizide an oral anti-diabetic agent a second generation sulfonylurea is poorly soluble in water and majorly absorbed from upper GI tract. It has an elimination half-life of about 2–4 h. It is a rapidly absorbed drug ... See full document

... Integrity of the drug in the formulation was checked by taking an IR spectrum of the selected formulation along with the drug and other excipients. The spectra obtained were compared using Shimadzu FTIR ... See full document

... the formulation of hydrochlorothizide floating ...The formulation F4-F6 containing of HPMC K 4M and carbopol 974 P showed more Bioadhesive strength than other ...The formulation F4 showed the ... See full document

... Hydrochloride floating microspheres to improve the bioavailability by increasing residence time in ...release floating microspheres. Thus, the development of floating drug delivery ... See full document

... Dimethylbiguanide floating microspheres to improve the bioavailability by increasing residence time in ...release floating microspheres. Thus, the development of floating drug delivery ... See full document

... including floating, hydrogels etc., among these the gastric floating DDS offers several advantages for those drugs associated with poor bioavailability and narrow absorption window in the GIT upper part ... See full document

... Optimized formulation F8 was chosen for stability studies based on their percentage yield, percentage drug entrapment efficiency and in-vitro drug release ...the microspheres indicating that the ... See full document

... Oral controlled drug delivery systems helps to achieve stable therapeutic plasma drug concentrations in contrary to the conventional formulations. These dosage forms show better patient compliance and predictable drug ... See full document

... Microspheres (100mg) were taken, thoroughly crushed by trituration and suspended in a minimal amount of dichloromethane for dissolving the coat shell of the microspheres. The suspension was suitably diluted ... See full document

... Practical drug content was analyzed by using the following procedure, weighed amount of Timolol floating microspheres equivalent to eight mg of Timolol floating microspheres was dissolved in ... See full document

... optimized formulation RF22 containing Gellan Gum and a gas-generating ...optimized formulation RF22 showed drug release of ...optimized formulation RF22 was low enough prolonging drug ... See full document