[PDF] Top 20 Gene expression-based risk score in diffuse large B-cell lymphoma

... Tan B, Goldschmidt N, Iqbal J, Vose J, Bast M, Fu K, Weisenburger DD, Greiner TC, Armitage JO, Kyle A, May L, Gascoyne RD, Connors JM, Troen G, Holte H, Kvaloy S, Dierickx D, Verhoef G, Delabie J, Smeland EB, ... See full document

... basal expression of PiK3ca and p-aKT was detected in six different kinds of DlBcl cell lines that were involved in the ...(B) Based on the successfully stable knockdown of PiK3ca (inserted ... See full document

... activated B cell DLBCLs (ABC-DLBCLs), a class of DLBCLs that respond poorly to current therapies, chromosomal translocations and amplification lead to constitutive expression of the B ... See full document

... were based on data using low volume cDNA synthesis, the initial analysis using separate multiple imputation of low-volume & high-volume data and the Lossos predictor formula was undertaken (n=162 patients) [3, ... See full document

... Keywords: diffuse large B-cell lymphoma, gene expression profile, differentially expressed genes, survival analysis, ... See full document

... Diffuse large B-cell lymphoma (DLBCL) is the most common type of non-Hodgkin ...average expression were found in refractory patients. The expression profile revealed ... See full document

... of diffuse large B-cell lymphoma in at least some ...a cell with increased risk of malignant ...the gene; this change is necessary for ... See full document

... Patients pathologically diagnosed with DLBCL and healthy individuals were recruited in the study. 206 peripheral blood specimens were collected from DLBCL patients diagnosed at Tianjin Medical University Can- cer ... See full document

... & Lymphoma Society Career Development Award, the Bernstein Family Fund for Leukemia and Lymphoma Research and the National Institutes of Health (K08CA134919), National Center for Advancing Translational ... See full document

... prognostic score based on nutritional status and PNI as biomarkers that can be used to independently predict the prognosis of DLBCL patients in terms of OS and ... See full document

... A-DLBCL based on morphology and recog- nized the distinctiveness of this neoplasm from ordinary DLBCLs in terms of genetic alterations and biologic fea- tures, which contained a high incidence of p53 positivity ... See full document

... Seven risk factors (age ...MYC expression, and high BCL-2 expression) of patients at diagnosis were identified, and a maximum of 7 points were assigned to each ...four risk groups: low (0–1), ... See full document

... tumors based on immune phenotype (Table 3), and we have undertaken this ...Anaplastic large cell lympho- ma (ALCL) cells are often positive for T cell markers, such as CD2, CD3, CD5, CD7, ... See full document

... Results: Of the 106 patients, 71(67%) male and 78(73.6%) patients were <60 years of age. 72(67.9%) presented with B-symptoms, 62(58.5%) had stage III/IV, and 80(75.5%) had high LDH at diagnosis. 22(20.8%) had ... See full document

... elevation (890 U/L, upper normal 460 and 3176 ng/mL, upper normal 2150, respectively). Computed tomogra- phy (CT) revealed mediastinal lymphadenopathy and bilateral lung involvement. Histological examination of a lymph ... See full document

... malignant lymphoma represents uncommon ...the risk of cardiac failure. Consequently, large numbers of those patients pass away before taking chemotherapy and they are diagnosed ...malignant ... See full document

... As a secondary lymphoid organ, the spleen is usually involved as part of the systemic illness. However, the spleen is rarely the exclusive site of the disease burden. DLBCL of the spleen accounts for about one-third of ... See full document

... ABC: B cell activated or non-germinal centre; B-CLU/DLBCL/LB: B-cell lymphoma unclassifiable, with features intermediate between diffuse large B-cell ... See full document

... Hodgkin Lymphoma (cHL), diffuse large B-cell lymphoma (DLBCL) associ- ated or not with EBV, primary cutaneous anaplastic large cell lymphoma, lymphomatous ... See full document

... of diffuse large B cell lymphoma is usually a manifestation of systemic disease rather than primary pulmonary lymphoma ...pulmonary lymphoma in the setting of HIV have ... See full document