[PDF] Top 20 The herpes simplex virus latency-associated transcript is spliced during the latent phase of infection.
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The herpes simplex virus latency-associated transcript is spliced during the latent phase of infection.
... In rabbits latently infected with McKrae strain virus, the spliced species comprised as much as 50% of the total LATs; this proportion was also seen in RNA isolated from mouse sensory ne[r] ... See full document
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Herpes Simplex Virus Latency-Associated Transcript Sequence Downstream of the Promoter Influences Type-Specific Reactivation and Viral Neurotropism
... daily during acute infection (14 days) for lesion severity around the vulva (on a scale from 0 to 4, where 0 means no disease, 1 means redness/swelling, 2 means one or two lesions, 3 means three to five ... See full document
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Detection of herpes simplex virus type 1 latency-associated transcript expression in trigeminal ganglia by in situ reverse transcriptase PCR.
... of herpes simplex virus type 1 (HSV-1) infection is the ability of the virus to establish a lifelong latent state in ...HSV latency-associated tran- scripts ... See full document
5
During Herpes Simplex Virus Type 1 Infection of Rabbits, the Ability To Express the Latency-Associated Transcript Increases Latent-Phase Transcription of Lytic Genes
... that, during latency, a LAT promoter deletion virus displayed greater leakiness of lytic transcripts than did the wild type in mice infected via the ocular route ...viruses during ... See full document
5
A 348-base-pair region in the latency-associated transcript facilitates herpes simplex virus type 1 reactivation.
... Latency-associated transcript (LAT) promoter deletion mutants of herpes simplex virus type 1 have a reduced capacity to reactivate following adrenergic induction in the rabbit ... See full document
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A Herpes Simplex Virus Type 1 Latency-Associated Transcript Mutant with Increased Virulence and Reduced Spontaneous Reactivation
... bovine herpes virus LR-RNA (latency-related RNA, comparable to LAT) encodes products that promote neuronal survival (8, ...of latent viral DNA or decreased numbers of latent viral ... See full document
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The abundant latency-associated transcripts of herpes simplex virus type 1 are bound to polyribosomes in cultured neuronal cells and during latent infection in mouse trigeminal ganglia.
... primary infection, herpes simplex virus type 1 (HSV-1) colonizes the human peripheral sensory ganglia (PSG), establishes latent infection, and can undergo periodic reactivations ... See full document
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Transcription of the Herpes Simplex Virus Latency-Associated Transcript Promotes the Formation of Facultative Heterochromatin on Lytic Promoters
... promoters during la- tency ...The virus used by Wang et ...following infection with KdlLAT compared to KFS- LAT, it was possible that deletion of cis-acting DNA sequences and not reduced LAT ... See full document
9
Downstream regulatory elements increase acute and latent herpes simplex virus type 2 latency-associated transcript expression but do not influence recurrence phenotype or establishment of latency.
... inoculation, herpes simplex virus (HSV) establishes latency in the sensory ganglia inner- vating that ...the virus may reactivate to cause symptomatic or asymptomatic recurrences (4, ... See full document
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In vivo deletion analysis of the herpes simplex virus type 1 latency-associated transcript promoter.
... off during latency (19, ...deletion virus KOS29 this region is intact and no LAT intron is observed in latent infections of mouse dorsal root ganglia ...leukemia virus was able to ... See full document
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Herpes Simplex Virus Type 1 Latency-Associated Transcript Gene Promotes Neuronal Survival
... PFU of 17syn⫹, 17-AHRI, 17-AH, 17-FA94, or 17-FA94R, groups of four mice were processed as above at days 6, 10, or 15 p.i., and 8-m sections were analyzed for TUNEL-positive cells. To facilitate interpretation of the ... See full document
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Expression of the Pseudorabies Virus Latency-Associated Transcript Gene during Productive Infection of Cultured Cells
... pseudorabies virus (PrV), is clas- sified as a member of the Alphaherpesvirinae subfamily within Herpesviridae (6, 26, ...This virus produces neurological, respiratory, and reproductive disease (Aujeszky’s ... See full document
8
A Novel Herpes Simplex Virus Type 1 Transcript (AL-RNA) Antisense to the 5′ End of the Latency-Associated Transcript Produces a Protein in Infected Rabbits
... produced during acute and/or latent infection in ...the virus in certain cell types and may play a role in the pathogenic potential of ... See full document
8
Herpes Simplex Virus Type 1 2-Kilobase Latency-Associated Transcript Intron Associates with Ribosomal Proteins and Splicing Factors
... During latency of herpes simplex virus type 1 in sensory neurons, the transcription of viral genes is restricted to the latency-associated transcripts ...is spliced ... See full document
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Tissue-Specific Splicing of the Herpes Simplex Virus Type 1 Latency-Associated Transcript (LAT) Intron in LAT Transgenic Mice
... neurons. During experimental HSV-1 infection of mice, the LAT is preferen- tially expressed in a particular subset of neuronal cells of DRG and TG ... See full document
10
The 2.2-Kilobase Latency-Associated Transcript of Herpes Simplex Virus Type 2 Does Not Modulate Viral Replication, Reactivation, or Establishment of Latency in Transgenic Mice
... HSV-2 latency and the factors that induce reactivation have been the subjects of extended ...genome during acute infection, only one family of transcripts is readily detected in ...these ... See full document
7
The herpes simplex virus type 1 2.0-kilobase latency-associated transcript is a stable intron which branches at a guanosine.
... Herpes simplex virus type 1 (HSV-1) is neurotropic virus capable of forming latent infections for the lifetime of an ...individual. During latency, transcription is ... See full document
10
Herpes Simplex Virus Type 1 Latency-Associated Transcript Expression Protects Trigeminal Ganglion Neurons from Apoptosis
... Herpes simplex virus type 1 (HSV-1) infects epithelial cells and undergoes an active lytic ...a latent in- fection, which lasts for the life of the neuron, while maintaining the ability to ... See full document
7
Neuronal Subtype Determines Herpes Simplex Virus 1 Latency-Associated-Transcript Promoter Activity during Latency
... lishes latency in trigeminal ganglia (TG), while HSV-2 usually infects the genital epithe- lium and establishes latency in dorsal root ganglia (DRG) ...productive infection than other subpopulations, ... See full document
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Genetic Studies Exposing the Splicing Events Involved in Herpes Simplex Virus Type 1 Latency-Associated Transcript Production during Lytic and Latent Infection
... Herpes simplex virus type 1 (HSV-1) establishes latency in sensory neurons, a state in which the viral lytic genes are silenced and only the latency locus is transcriptionally active, ... See full document
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