[PDF] Top 20 Human T-cell leukemia virus type II nucleotide sequences between env and the last exon of tax/rex are not required for viral replication or cellular transformation.
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Human T-cell leukemia virus type II nucleotide sequences between env and the last exon of tax/rex are not required for viral replication or cellular transformation.
... Human T-cell leukemia virus types I (HTLV-I) and II (HTLV-II) and bovine leukemia virus contain a region of approximately 600 nucleotides located 3 * to the ... See full document
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The tax gene of human T-cell leukemia virus type 2 is essential for transformation of human T lymphocytes.
... Human T-cell leukemia virus type 1 (HTLV-1) and type 2 (HTLV-2) are oncogenic retroviruses associated with human T-cell malignancies and degenerative ... See full document
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Human T-Cell Leukemia Virus Type 1 Expressing Nonoverlapping Tax and Rex Genes Replicates and Immortalizes Primary Human T Lymphocytes but Fails To Replicate and Persist In Vivo
... example, tax/ rex mRNA is one of the initial transcripts to be made upon viral integration ...mRNAs. Rex, for instance, is needed for full expression of incompletely spliced gag, pol, and ... See full document
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Phosphorylation of Two Serine Residues Regulates Human T-Cell Leukemia Virus Type 2 Rex Function
... Human T-cell leukemia virus (HTLV) types 1 (HTLV-1) and 2 (HTLV-2) are complex retroviruses that have been caus- ally associated with leukemia and neurological disorders in ... See full document
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Envelope Is a Major Viral Determinant of the Distinct In Vitro Cellular Transformation Tropism of Human T-Cell Leukemia Virus Type 1 (HTLV-1) and HTLV-2
... functional viral promoter as well as viral transregu- latory proteins Tax and Rex; the concentration of p19 Gag in the supernatant of transfected cells has been used as a measure of virion ... See full document
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Repression of Human T-Cell Leukemia Virus Type 1 and Type 2 Replication by a Viral mRNA-Encoded Posttranscriptional Regulator
... and Env, HTLV encodes the Tax and Rex trans-regulatory gene products that are essential for efficient viral replication and cellular ...transformation. Tax ... See full document
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Mutational analysis of human T-cell leukemia virus type 2 Tax.
... Human T-cell leukemia virus type 1 (HTLV-1) and type 2 (HTLV-2) contain at least two trans-regulatory genes, tax and rex (23, 27, 39, ...Both Tax and ... See full document
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Human T-Cell Leukemia Virus Type 2 Rex Protein Increases Stability and Promotes Nuclear to Cytoplasmic Transport of gag/pol and env RNAs
... Human T-cell leukemia virus types 1 and 2 (HTLV-1 and HTLV-2) are complex oncogenic retroviruses that transform primary human T cells in culture and are associated with ... See full document
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Phosphorylation regulates human T cell leukemia virus type 1 Rex function
... and env, HTLV encodes two trans-regu- latory genes, tax and rex, which are essential for efficient viral replication/transformation, as well as several acces- sory genes ... See full document
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Human T-Cell Leukemia Virus Type 2 Rex Carboxy Terminus Is an Inhibitory/Stability Domain That Regulates Rex Functional Activity and Viral Replication
... of Rex-2 through phosphorylation provides a critical control in HTLV-2 repli- cation cycle at the cellular level, which would allow the virus to better adjust to environmental stimuli (31, ...Mutant ... See full document
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Site-Specific Phosphorylation Regulates Human T-Cell Leukemia Virus Type 2 Rex Function In Vivo
... the cellular protein Pin1 in the Rex-2 pulldown complex (data not ...the cellular kinase to phosphorylate ...7. Rex-2 phosphorylation continuum and function model. The newly ... See full document
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Inactivation of tumor suppressor Dlg1 augments transformation of a T cell line induced by human T cell leukemia virus type 1 Tax protein
... mouse T-cell line, the growth of which is dependent on ...induces cell growth arrest [34], CTLL-2 is resistant to such Tax1 activ- ity, thereby being a useful tool to examine the transform- ing ... See full document
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Nuclear Export and Expression of Human T-Cell Leukemia Virus Type 1 tax/rex mRNA Are RxRE/Rex Dependent
... the viral long terminal repeat (LTR) (15, 23, 26, 30). Rex has at least three domains that are important for its functions: an arginine-rich re- gion important for binding to the Rex-responsive ... See full document
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Rex transregulation of human T-cell leukemia virus type II gene expression.
... In this regard, Rex resembles the Rev protein of human immunodeficiency virus type 1 HIV-1 that augments the cytoplasmic expression of unspliced HIV-1 mRNAs 28, 29 and functions through [r] ... See full document
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Multiple isolates and characteristics of human T-cell leukemia virus type II.
... 2456 Downloaded from http://jvi.asm.org/ on November 9, 2019 by guest Human T-cell leukemia or lymphotropic virus type II HTLV-II was isolated from eight HTLVseropositive patients, six o[r] ... See full document
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Genetic heterogeneity in human T-cell leukemia/lymphoma virus type II.
... In fact, the heterogeneity among HTLV-II strains from the Western Hemisphere was similar to that observed in HTLV-I and simian T-cell lymphoma/leukemia virus type I isolates from around [r] ... See full document
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Inhibition of human T-cell leukemia virus type 2 Rex function by truncated forms of Rex encoded in alternatively spliced mRNAs.
... of Rex structure and function sug- gests three possible mechanisms whereby a mutant Rex protein could inhibit wild-type Rex: (i) competition for required cel- lular factors by a mutant ... See full document
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Human T-Cell Leukemia Virus Type 1 Tax Attenuates the ATM-Mediated Cellular DNA Damage Response
... association between genome instabil- ity and carcinogenesis. Infection with human T-cell leukemia vi- rus type 1 (HTLV-1), an oncogenic retrovirus, is associated with the ... See full document
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Human T-Cell Leukemia Virus Type 1 Tax Shuttles between Functionally Discrete Subcellular Targets
... of Tax in TSS colocalizes with sites of transcription. Tax predominately localizes to the nucleus of cells, displays a speckled pattern, and is excluded from the nucleolus (41, ...significant ... See full document
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Host Sequences Flanking the Human T-Cell Leukemia Virus Type 1 Provirus In Vivo
... The nucleotide composition of the flanking sequences was analyzed, and their homologies to known sequences were iden- ...flanking sequences was com- pared to that of uninfected ...the ... See full document
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