[PDF] Top 20 The human T transcription factor: A study of genetics and function
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The human T transcription factor: A study of genetics and function
... observations (Kispert and Herrmann, 1993), but in agreem ent w ith the crystallographic structure o f the T/DNA complex. However, Casey et al. (1998) were only able to dem onstrate w eak binding of in vitro ... See full document
264
Missouri Mothers and Their Children: A Family Study of the Effects of Genetics and the Prenatal Environment
... Behavior Genetics on the prenatal ...executive function and processing speed in real- world activities as well as in neuropsychological testing, and that cognitive deficits detected by standardized ... See full document
12
Change in Depression Symptomatology and Cognitive Function in Twins: A 10-Year Follow-Up Study
... detailed study of the genetic nature of cognitive level and change in these middle-aged twins, reaching the final conclusion that the change in cognition can be attributed mainly to non-shared environment (McGue ... See full document
8
Genetic Influence on Left Ventricular Structure and Function: A Korean Twin and Family Study
... of genetics on LV function is not well established, especially in Asian ...populations. Study subjects were 1,642 healthy Korean adults from 426 families, consisting of 298 pairs of monozygotic ... See full document
9
The genetics and the molecular functions of the PREP1 homeodomain transcription factor
... recent study on the effect of YAP down-regulation on retinal stem cell population has uncovered several key phenotypes reminiscent of Prep1 down-regulation like the reduced size or absence of the eye, changes in ... See full document
8
Persistent activation of NF-kappa B/Rel by human T-cell leukemia virus type 1 tax involves degradation of I kappa B beta.
... B/Rel transcription factors by various cytokines and mitogens is a transient event, reflecting the fact that these inducers trigger the degradation and resynthesis of the dynamic NF- k B/Rel inhibitor I k B a ... See full document
6
Are the Variants of the Circle of Willis Determined by Genetic or Environmental Factors? Results of a Twin Study and Review of the Literature
... the human brain, its functional demand leads to hemodynamic changes, and thus, CW variations may arise as consequence of these effects (Van Overbeeke et ... See full document
10
Haploinsufficiency of Bcl11b suppresses the progression of ATM-deficient T cell lymphomas
... a transcription factor that is “ monoallelically ” inactivated in ~10 % of human T cell acute lymphoblastic leukemia (T-ALL) [1–3] and several murine T-ALL models, including ATM ... See full document
5
Transcription factor T bet regulates inflammatory arthritis through its function in dendritic cells
... any human disease have to be examined with a suitable degree of ...since human experimentation is, of course, not pos- ...the human disease, and this will be true in mouse RA ...of human dis- ... See full document
9
The Complementary Strand of the Human T-Cell Leukemia Virus Type 1 RNA Genome Encodes a bZIP Transcription Factor That Down-Regulates Viral Transcription
... trans-activation function through binding to promoters of cel- lular genes and disturb the normal expression of these ...of T-cell lymphoma and a demyelinating disease, and MEQ has been suggested to be ... See full document
10
Curcumin targets the TFEB-lysosome pathway for induction of autophagy
... activates transcription factor EB (TFEB), a key nuclear transcription factor in control of autophagy and lysosome biogenesis and function, based on the following observations: (i) ... See full document
13
The C-Rel Transcription Factor Controls Metabolism And Proliferation Of Human T Cells
... Metabolic alteration is also implicated in failed immune responses. For example, TCR stimulation with incomplete CD28 co-stimulation leads to failure to switch from OXPHOS to glycolysis, causing deficiency in nutrient ... See full document
101
The changes and its significance of Th17 and Treg cells and related cytokines in patients with tuberculosis pleurisy
... -stimulating factor, GM-CSF). Treg cells were a kind of CD4 + T cells with specific expres- sion of transcription factor Foxp3 and negative immune regulatory ...+ T cells, and were ... See full document
6
The T box transcription factor Brachyury promotes epithelial mesenchymal transition in human tumor cells
... The human pancreatic cell line PANC-1 was only used here as a model cell line to investigate the effect of Brachyury overexpression in an epithelial cancer ...the transcription factor Slug, but not ... See full document
13
Human T-Cell Leukemia Virus Type 1 (HTLV-1) bZIP Factor Requires Cellular Transcription Factor JunD To Upregulate HTLV-1 Antisense Transcription from the 3′ Long Terminal Repeat
... the human T-cell leukemia virus type 1 (HTLV-1) results in a variety of diseases including adult T-cell leukemia (ATL), a fatal malignancy characterized by the uncontrolled proliferation of virally ... See full document
9
In silico design of context-responsive mammalian promoters with user-defined functionality
... scription factor regulatory elements (TFREs). In this study, we show that modular binding sites that do not function cooperatively can be identified by analyz- ing host cell transcription ... See full document
14
NKX6.1 transcription factor: A crucial regulator of pancreatic -cell development, identity, and proliferation
... Understanding the biology underlying the mechanisms and pathways regulating pancreatic β-cell development is necessary to understand the pathology of diabetes mellitus (DM), which is characterized by the progressive ... See full document
32
Etiologies of the Relationships Among Body Mass Index and Cold-Heat Patterns: A Twin Study
... present study was com- prised of eight items for typical symptoms of the CP and seven items for typical symptoms of the HP (see Table 2 in Hur et ...through factor analysis and clinicians’ di- agnostic ... See full document
6
Cohesin mutations in myeloid malignancies: underlying mechanisms
... as t(15;17), t(8:21), inv(16), t(9;21), t(9;11) are charac- teristic of AML, and suggest that genetic events play a key role in leukemogenesis ...and transcription, and these functions ... See full document
8
Heritability of Cold and Heat Patterns: A Twin Study
... which NEI-related genes and chemical messengers (CM: hormones, cytokines, and neurotransmitters) are related to the CP and the HP network by using a co-occurrence literature mining approach (Jenssen et al., 2001; Li et ... See full document
6
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