[PDF] Top 20 CCR8 on Human Thymocytes Functions as a Human Immunodeficiency Virus Type 1 Coreceptor
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CCR8 on Human Thymocytes Functions as a Human Immunodeficiency Virus Type 1 Coreceptor
... transiently in human thymic implants (1). However, effective inhibition of viral replication was achieved when multidrug therapy was initiated immediately after infection of the thymic implant (26). Since ... See full document
7
Identification of a Subset of Human Immunodeficiency Virus Type 1 (HIV-1), HIV-2, and Simian Immunodeficiency Virus Strains Able To Exploit an Alternative Coreceptor on Untransformed Human Brain and Lymphoid Cells
... and CCR8 were undetectable on ⌬32/⌬32 PBMCs after 25 cycles, a signal was detected after amplifica- tion for 35 cycles ...CCR3, CCR8, GPR1, and GPR15, were negative on all other primary cell cultures after ... See full document
15
Amino-Terminal Substitutions in the CCR5 Coreceptor Impair gp120 Binding and Human Immunodeficiency Virus Type 1 Entry
... the human immu- nodeficiency virus type 1 (HIV-1) envelope glycoproteins to initiate viral entry into target cells (1, 11, 15, 17, 20, ...their coreceptor specificity; ... See full document
7
Differential Tropism and Replication Kinetics of Human Immunodeficiency Virus Type 1 Isolates in Thymocytes: Coreceptor Expression Allows Viral Entry, but Productive Infection of Distinct Subsets Is Determined at the Postentry Level
... fresh thymocytes, determined by both surface and intracellular staining, was detected on few ...in thymocytes by ligand occupation or virus ...on thymocytes with 2D7, this antibody could block ... See full document
12
V3 Recombinants Indicate a Central Role for CCR5 as a Coreceptor in Tissue Infection by Human Immunodeficiency Virus Type 1
... Incomplete eradication of HIV-1 after triple-drug therapy has been attributed in part to the hypothesized separation and relative protection of tissue reservoirs of latent virus from viral populations ... See full document
9
Primary Infection by a Human Immunodeficiency Virus with Atypical Coreceptor Tropism
... of human immunodeficiency virus type 1 (HIV-1) strains enter CD4 ⴙ target cells by interacting with one of two coreceptors, CCR5 or ...(T/F) virus (ZP6248) that was ... See full document
13
Use of Inhibitors To Evaluate Coreceptor Usage by Simian and Simian/Human Immunodeficiency Viruses and Human Immunodeficiency Virus Type 2 in Primary Cells
... tropic virus in PBMC was inhibited only by very high concentrations of AMD3100 and was com- pletely insensitive to SDF-1␣, TAK-779, or ...tive coreceptor to enter human PBMC, perhaps the CXCR5 ... See full document
18
Functional Correlation of P-Glycoprotein Expression and Genotype with Expression of the Human Immunodeficiency Virus Type 1 Coreceptor CXCR4
... (22). The authors concluded that P-gp expression inhibited HIV-mediated membrane fusion, as well as a subsequent step(s) in the HIV-1 life cycle. Recently, Speck et al. reported similar data for drug-selected ... See full document
8
Human Immunodeficiency Virus Type 1 Coreceptor Preferences Determine Target T-Cell Depletion and Cellular Tropism in Human Lymphoid Tissue
... R5 virus- infected cultures as assessed at day 12 postinfection ...of virus with very similar kinetics as assessed by the p24 content of culture supernatants ... See full document
5
Dendritic Cell–T-Cell Interactions Support Coreceptor-Independent Human Immunodeficiency Virus Type 1 Transmission in the Human Genital Tract
... Our data suggest that mucosal macrophages and T cells, rather than DC, may be the early targets for R5-tropic HIV-1 entry following sexual exposure. This is underscored by the finding that purified genital DC are ... See full document
10
Cytopathicity of Human Immunodeficiency Virus Type 1 Primary Isolates Depends on Coreceptor Usage and Not Patient Disease Status
... vivo human lymphoid histocultures, it has been established that X4 viruses are more cytopathic than R5 viruses (13, 14, 18) and specifically that late X4 viruses are more cytopathic than early R5 viruses ...of ... See full document
6
Population Based Sequencing of the V3 Region of env for Predicting the Coreceptor Usage of Human Immunodeficiency Virus Type 1 Quasispecies
... entire virus population was ...certain virus clones are ...25 virus population was determined from the start to the insertion/deletion site in the sense direction and from the end back to the ... See full document
9
Determinants of CD4 Independence for a Human Immunodeficiency Virus Type 1 Variant Map outside Regions Required for Coreceptor Specificity
... ing mechanism for this effect is unclear, regions of the HIV-1 TM have been implicated in a number of cooperative interac- tions with gp120 that could affect its binding to CD4 and/or chemokine receptors (5, 7, ... See full document
10
Microglia Express CCR5, CXCR4, and CCR3, but of These, CCR5 Is the Principal Coreceptor for Human Immunodeficiency Virus Type 1 Dementia Isolates
... day 1 after isolation ...a coreceptor, and why virus is present in the brains of many patients with or without HIVD ...certain coreceptor repertoire to infect the parenchymal microglia, which ... See full document
9
Modulation of Different Human Immunodeficiency Virus Type 1 Nef Functions during Progression to AIDS
... To investigate their effect on CD4 and class I MHC cell surface expression, the five consensus nef alleles were cloned in a bicistronic expression vector containing nef followed by GFP under the control of an internal ... See full document
9
N-Linked Glycosylation of CXCR4 Masks Coreceptor Function for CCR5-Dependent Human Immunodeficiency Virus Type 1 Isolates
... functional coreceptor for otherwise-restricted R5 isolate ...principal coreceptor, CCR5, does not appear to possess any N-linked glycosylation modifications, although there is a potential site in the ... See full document
10
Physiological Levels of Virion-Associated Human Immunodeficiency Virus Type 1 Envelope Induce Coreceptor-Dependent Calcium Flux
... To gain insight into how virion binding correlates to the Ca 2⫹ fluxing pattern, the number of viral particles bound to each T cell were counted. After the fluxing experiments, the cells were fixed and stained for HIV ... See full document
13
Frequent Intrapatient Recombination between Human Immunodeficiency Virus Type 1 R5 and X4 Envelopes: Implications for Coreceptor Switch
... on coreceptor usage and HIV-1 ...and coreceptor usage of V1-V3 clones from sequential isolates from four switch virus ...with coreceptor usage data made it possible for us to perform a ... See full document
8
No Selection for CCR5 Coreceptor Usage during Parenteral Transmission of Macrophagetropic Syncytium-Inducing Human Immunodeficiency Virus Type 1
... the coreceptor usage of biological HIV-1 clones obtained from the virus donors around the moment of transmission and from the recipients at one or two time points after seroconversion ...biological ... See full document
6
Coreceptor Utilization by Human Immunodeficiency Virus Type 1 Is Not a Primary Determinant of Neutralization Sensitivity
... The discovery of cellular coreceptors for HIV has provided new perspectives for understanding these early events in HIV infection (see review in reference 2). Thus, phenotypically dis- tinct isolates of HIV utilize as ... See full document
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