[PDF] Top 20 Identification of sequences downstream of the primer binding site that are important for efficient replication of human immunodeficiency virus type 1.
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Identification of sequences downstream of the primer binding site that are important for efficient replication of human immunodeficiency virus type 1.
... (nt) primer binding site (PBS), located within the 5 * region of viral genomic RNA, to which the host cell-derived tRNA primer is annealed and also involves viral genomic sequences ... See full document
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Leader Sequences Downstream of the Primer Binding Site Are Important for Efficient Replication of Simian Immunodeficiency Virus
... Simian immunodeficiency virus (SIV) infection of macaques is remarkably similar to that of human immunodeficiency virus type 1 (HIV-1) in humans, and the ... See full document
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Inhibition of recombinant human immunodeficiency virus type 1 replication by a site-specific recombinase.
... The binding of Cre to its natural target locus, loxP, has been well ...loxP site (22) contains two con- tiguous binding sites for Cre (31); each binding site contains one inverted ... See full document
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Identification of a sequence within U5 required for human immunodeficiency virus type 1 to stably maintain a primer binding site complementary to tRNA(Met).
... (25). Site-directed mutagenesis was carried out by two con- secutive PCRs ...mutant sequences were produced by the first PCR with a primer in the U3 region of the 5 9 long terminal repeat (5 9 ... See full document
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Nucleotide substitutions within U5 are critical for efficient reverse transcription of human immunodeficiency virus type 1 with a primer binding site complementary to tRNA(His).
... Viral replication was monitored by assaying the p24 antigen level in the culture supernatant and visual inspection for large, giant cell ...of virus from cultures transfected with pHXB2(His- AC-GAC) and ... See full document
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The roles of the human immunodeficiency virus type 1 Pol protein and the primer binding site in the placement of primer tRNA(3Lys) onto viral genomic RNA.
... of primer tRNA was copied and used for the continuation of positive-strand syn- thesis after the second template switch (7, 15, 32, ...to sequences that flank the PBS were observed only infrequently in ... See full document
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Redundant Roles for Nucleocapsid and Matrix RNA-Binding Sequences in Human Immunodeficiency Virus Type 1 Assembly
... to binding of RNA by multiple Gags, which in turn organizes and stabilizes the Gag-Gag interactions that form the ...the human immunodeficiency virus type 1 (HIV-1) Gag ... See full document
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Role of Stem B, Loop B, and Nucleotides next to the Primer Binding Site and the Kissing-Loop Domain in Human Immunodeficiency Virus Type 1 Replication and Genomic-RNA Dimerization
... of human immunodeficiency virus type 1 (HIV-1) genomic ...viral replication, genomic RNA dimerization, and dimer- ization of partial HIV-1 RNA ...complementary ... See full document
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Construction of a type 1 human immunodeficiency virus that maintains a primer binding site complementary to tRNA(His).
... of replication of viruses derived from pHXB2(His-T C ...had replication kinetics similar to those of the wild type, we favor the hypothesis that these additional mutations represent an evolution of ... See full document
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Human immunodeficiency virus type 1 can use different tRNAs as primers for reverse transcription but selectively maintains a primer binding site complementary to tRNA(3Lys).
... PBS sequences of proviruses derived from reverse transcription, mutant proviral genomes were constructed in which the PBS region was altered so that proviruses which were generated as a result of reverse ... See full document
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Identification of a replication-competent pathogenic human immunodeficiency virus type 1 with a duplication in the TCF-1alpha region but lacking NF-kappaB binding sites.
... B binding sites can enhance both LTR-driven reporter gene activity and viral replication (11, 25, 31, 36), whereas its deletion can impair viral replicative capacity in a variety of cell types such as pe- ... See full document
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Mutations in the U5 Region Adjacent to the Primer Binding Site Affect tRNA Cleavage by Human Immunodeficiency Virus Type 1 Reverse Transcriptase In Vivo
... HIV- 1(ATG) mutant, in which the canonical CA sequence was mutated to AT (Table ...that sequences other than the canonical CA were successfully integrated in an in vitro assay using RSV IN ...terminal ... See full document
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Effects of alterations of primer-binding site sequences on human immunodeficiency virus type 1 replication.
... During early stages of infection, the two PBS mutants, in conjunction with tRNA1Ls and tRNAPhe, appar- An early, critical step in the human immunodeficiency virus type HIV-1 life cycle i[r] ... See full document
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Transcription factor binding sites downstream of the human immunodeficiency virus type 1 transcription start site are important for virus infectivity.
... the human immunodeficiency virus (HIV) promoter contains a nucleosome- free region encompassing both the promoter/enhancer region and a large region (255 nucleotides [nt]) down- stream of the ... See full document
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Exon 1 leader sequences downstream of U5 are important for efficient human immunodeficiency virus type 1 gene expression.
... exon 1 leader sequence downstream of U5 influences basal, Tat-independent gene ...sequence downstream of U5, lsdU5 ...NarI site (N) at the 39 end of U5 (nt 1181) to a position 6 nt upstream of ... See full document
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An Exonic Splicing Silencer Downstream of the 3′ Splice Site A2 Is Required for Efficient Human Immunodeficiency Virus Type 1 Replication
... for efficient virus repli- ...activity downstream of HIV-1 3 ⬘ ss A2 is localized to a 16-nt element within the vif coding ...for binding of members of the hnRNP A/B protein family (5, ... See full document
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Inhibition of Human Immunodeficiency Virus Type 1 Replication with Artificial Transcription Factors Targeting the Highly Conserved Primer-Binding Site
... The virus responsible for the disease, human immunodeficiency virus (HIV), infects CD4 ⫹ T cells and establishes a latent pool of infected ...the virus to escape the effects of the ... See full document
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Structural Elements of the tRNA TΨC Loop Critical for Nucleocytoplasmic Transport Are Important for Human Immunodeficiency Virus Type 1 Primer Selection
... was determined by p24 antigen levels, using a commercially available enzyme-linked immunosorbent assay kit (Beckman Coulter, Miami, FL), and serial dilutions of the virus-contain- ing supernatant were used to ... See full document
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Opposite Effects of SDF-1 on Human Immunodeficiency Virus Type 1 Replication
... have important consequences for HIV ...viral replication in monocytes or macrophages (29, ...increase replication of X4 strains in PBLs by stimulating the transcription of the CXCR4 gene (19) or by ... See full document
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The tRNA Primer Activation Signal in the Human Immunodeficiency Virus Type 1 Genome Is Important for Initiation and Processive Elongation of Reverse Transcription
... in virus production and/or assembly indirectly affect the level of reverse ...severe virus production defect. The tRNA primer was extended by the addition of deoxynucleoside triphosphates and the ... See full document
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