[PDF] Top 20 Interaction of Epstein-Barr virus nuclear antigen 1 with the viral latent origin of replication.

... The presence of single and double point mutations in EBNA-1-binding site 2 did not alter the ability of EBNA-1 to induce KMnO4 reactivity at nucleotides 9046/9047 and 9110/9111, nor were[r] ... See full document

... of Epstein-Barr virus (EBV) plays several important roles in EBV latent infection, including activating DNA replication from the latent origin of replication (oriP) ... See full document

... EBV replication, plasmid maintenance or tran- scriptional activation (30, 45; our unpublished data), nor is the S21 site conserved in EBNA1 homologous in the EBV-like cynomolgus monkey virus and herpesvirus ... See full document

... is replication of chromosomes, we hypothesize that the replicated oriP plasmids are partitioned between the sister SARs on sister chromatids, by a distribution of EBNA1 or HMGA1a-DBD to each sister ...with ... See full document

... Epstein-Barr virus (EBV) nuclear antigen 3C (EBNA-3C) is one of five viral nuclear proteins that are essential for EBV-induced immortalization of primary human B ... See full document

... Epstein-Barr virus (EBV) persists in the nuclei of latently infected human B lymphocytes as double-stranded circular DNA episomes ...DNA replication per cell cycle and are efficiently ... See full document

... as interaction with a host cell ...sites 1 and 2 were changed from 5⬘-ACCCG-3⬘ to 5⬘-ATTTA-3⬘ in ...and replication effi- ciency of this plasmid, ...⫽ 1; Tables 2 and 3). Therefore, the ... See full document

... mini-EBV virus progeny is dependent on the lytic origin, oriLyt, and the packaging signals (terminal repeats) in ...all viral factors re- quired in trans, thereby supporting the lytic amplification ... See full document

... Unlike the interaction of bEBNA1 with onP, in which one element FR is bound prior to interaction Downloaded from http://jvi.asm.org/ on November 9, 2019 by guest a bEBNAl proteins 1.4 pm[r] ... See full document

... DNA replication initiation function (4). The replication and plasmid maintenance function of EBNA1 depends on linking region 1 (LR1) and ...in origin for- mation at several cellular origins ... See full document

... Epstein-Barr virus (EBV) is a DNA tumor virus that is associated with the pathogenesis of endemic Burkitt’s lym- phoma, Hodgkin’s lymphoma, and posttransplant ...EBV nuclear ... See full document

... this interaction would in any way differ from that of the other herpesvirus subfamily ...this virus is also clearly associated with several types of cancer such as Burkitt’s lymphoma and naso- pharyngeal ... See full document

... cellular replication foci or replication factories (8, 10, 19, 20, 27, 31), in the absence of EBV ...for interaction with RP-A (48) is depicted on the ...(lane 1), nucleoplasmic (lane 2), ... See full document

... EBNA-3C, in addition to its well-defined role as a repressor of EBNA-2-mediated activation of transcription (via interac- tion with J␬), can also activate gene expression. EBNA-3C contains a potential basic leucine ... See full document

... Epstein-Barr virus (EBV) is causatively associated with the development of nasopharyngeal carcinoma (NPC), as almost all undifferentiated NPCs are comprised of monoclonal expan- sions of cells ... See full document

... * 1786 Downloaded from http://jvi.asm.org/ on November 10, 2019 by guest The Epstein-Barr virus nuclear antigen 1 EBNA1 protein binds and activates the latent replication origin oriP of [r] ... See full document

... It seems noteworthy that the sequence of 20-bp repeats from the human distal part of the pJE clone displays a high level of identity with some markers with variable numbers of terminal r[r] ... See full document

... with Epstein-Barr virus nuclear antigen-1 or with any other EBV protein, but forms complexes with other ...a viral protein which generates cross-reacting antibodies to the ... See full document

... Although region I is required for the transient replication of plasmids bearing region II in EBV-infected B cells, a plasmid lacking region I but containing region II, was observed to re[r] ... See full document

... EBNALP binds to EP300 in LCLs. Since EBNALP has a dramatic effect on EP300 transcription activity, we tested whether EBNALP can physically associate with EP300 in protein complexes. EBNALP was immunoprecipitated by the ... See full document