[PDF] Top 20 Interaction of the lymphocyte-derived Epstein-Barr virus nuclear antigen EBNA-1 with its DNA-binding sites.

... DNA filter binding assays and DNase I footprinting experiments showed that the intact Raji EBNA-1 protein recognized the two binding site loci in oriP and the BamHI-Q locus and no other [r] ... See full document

... The Epstein-Barr virus (EBV) nuclear antigen 3C (EBNA-3C) protein is a transcriptional regulator of viral and cellular genes that is essential for EBV-mediated immortalization of ... See full document

... that EBNA-3C contains sequences that are homol- ogous to the activation domain of the cellular transcription factor Sp1 is consistent with our demonstration that EBNA-3C can activate expression from the ... See full document

... of EBNA-1 are likely to inhibit wild-type EBNA-1 when they occupy only a subset of the binding sites on ...20 binding sites for EBNA-1 are present in ... See full document

... EBNA1 binding to the DS and FR elements activates DNA replication and transcription, re- spectively, are currently unclear, although considerable infor- mation is accumulating on the mechanism of initiation ... See full document

... The Epstein-Barr virus (EBV) nuclear antigen 3C (EBNA-3C) regulates virus and cell genes and is essential for EBV-mediated transformation of primary B ...lymphocytes. ... See full document

... EBNA3C binding signal was present at each of the three EBNA3C- bound sites (BACH2, JAK1, and CXCR5) in EBNA3C-HT cells grown in the presence of 4HT and markedly declined upon 4HT ...RBPJ binding to ... See full document

... a DNA-binding do- main (DBD), bZIP, and domains rich in acidic, proline, and glutamine residues which are candidates for regions that mod- ulate ...binds DNA-cellulose (20, 41), a specific ... See full document

... Epstein-Barr virus (EBV) persists in the nuclei of latently infected human B lymphocytes as double-stranded circular DNA episomes ...of DNA replication per cell cycle and are ... See full document

... Epstein-Barr virus (EBV) is a DNA tumor virus that is associated with the pathogenesis of endemic Burkitt’s lym- phoma, Hodgkin’s lymphoma, and posttransplant ...EBV nuclear ... See full document

... and nuclear extracts from various cells lines, including at least four of the BJAB clones expressing EBNA 3A, 3B, or 3C, Raji, and EBV-transformed LCLs ...(Fig. 1 and data not shown). As expected, ... See full document

... of its interaction with USP7 or ...this interaction is direct or mediated by another protein ...the interaction with CK2 occurs through the ␤ regulatory ...by its C-terminal ... See full document

... of EBNA-1 to inhibit splicing and possibly other pre-mRNA processing appears to be strictly dependent on the context of the EBNA-1 binding sites within the gene ...which ... See full document

... of EBNA-1 gene across amino acid 487 – 595 (nucleotides 97120 – ...with DNA binding and core domain (amino acid 504 – 604), which related to the regulation of dimerization, belonged to the ... See full document

... The Epstein-Barr Virus (EBV) Nuclear Antigen 1 (EBNA1) protein is required for the establishment of EBV latent infection in proliferating ...multifunctional ... See full document

... the DNA fragments amplified by PCR using the appropriate primer ...tagged EBNA-LP domain fused to the GAL4 DNA binding domain and the series of deletion mutants of pM-W2(H) shown in ...of ... See full document

... Epstein-Barr virus (EBV) nuclear antigen leader protein (EBNA-LP) consists of W1W2 repeats and a unique C-terminal Y1Y2 domain and has been suggested to play an important role in ... See full document

... The presence of single and double point mutations in EBNA-1-binding site 2 did not alter the ability of EBNA-1 to induce KMnO4 reactivity at nucleotides 9046/9047 and 9110/9111, nor were[r] ... See full document

... tinguishable sites of EBNA1 binding, the family of repeats and the dyad symmetry ...EBNA1-binding sites that is important for transcription regulation and episome segregation and maintenance ... See full document

... In previous studies of infectious mononucleosis, we found IgM autoantibodies which react with hematopoietic cell antigens. Many of these were inhibited by synthetic glycine/alanine peptides representing the ... See full document