[PDF] Top 20 The Stable 2.0-Kilobase Intron of the Herpes Simplex Virus Type 1 Latency-Associated Transcript Does Not Function as an Antisense Repressor of ICP0 in Nonneuronal Cells
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The Stable 2.0-Kilobase Intron of the Herpes Simplex Virus Type 1 Latency-Associated Transcript Does Not Function as an Antisense Repressor of ICP0 in Nonneuronal Cells
... LAT intron may encode a protein. The LAT is associated with the polyribosome fraction of lytically and latently infected cells (20), and an open reading frame (ORF) within the ...LAT intron ... See full document
15
The 2-Kilobase Intron of the Herpes Simplex Virus Type 1 Latency-Associated Transcript Has a Half-Life of Approximately 24 Hours in SY5Y and COS-1 Cells
... The herpes simplex virus type 1 (HSV-1) 2-kb latency-associated transcript (LAT) is a stable intron, which accumulates in cells ... See full document
9
Regions of the Herpes Simplex Virus Type 1 Latency-Associated Transcript That Protect Cells from Apoptosis In Vitro and Protect Neuronal Cells In Vivo
... context does the LAT region of the genome exert an antiapoptotic effect? Initially, we hypothesized that the intact stable ...LAT intron that was expressed by the ...LAT intron, expressed by ... See full document
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Construction of a Herpes Simplex Virus Type 1 Mutant with Only a Three-Nucleotide Change in the Branchpoint Region of the Latency-Associated Transcript (LAT) and the Stability of Its Two-Kilobase LAT Intron
... the 2-kb LAT has been shown to down-regulate productive infections in sensory neurons and suppress viral replication (12, 22, 39), thus pro- moting the establishment of latent infection in these neurons (43, 56, ... See full document
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Herpes Simplex Virus Type 1 Latency-Associated Transcript Gene Promotes Neuronal Survival
... establishment function we identified in the mouse was mapped to a ...the stable LAT locus introns known as the LATs ...of latency is not yet ...the cells undergoing apoptosis are neurons ... See full document
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The herpes simplex virus type 1 latency-associated transcript gene regulates the establishment of latency.
... may function as a natural antisense mechanism to down regulate viral gene tran- scription in neurons ...wild type in its ability to reactivate in a timely manner in an in vitro cocultivation assay, ... See full document
9
The 2.2-Kilobase Latency-Associated Transcript of Herpes Simplex Virus Type 2 Does Not Modulate Viral Replication, Reactivation, or Establishment of Latency in Transgenic Mice
... HSV-2 latency and the factors that induce reactivation have been the subjects of extended ...in latency. The gene encoding these latency-associated transcripts (LATs) (5, 22) is about 9 ... See full document
7
The Stable 2-Kilobase Latency-Associated Transcript of Herpes Simplex Virus Type 1 Can Alter the Assembly of the 60S Ribosomal Subunit and Is Exported from Nucleus to Cytoplasm by a CRM1-Dependent Pathway
... the 2-kb LAT intron affect ribosome assembly or trans- lation? It is known that in the absence of sufficient numbers of functional 60S subunits to pair with, 40S ribosomal subunits will accumulate in ... See full document
7
The herpes simplex virus type 1 2.0-kilobase latency-associated transcript is a stable intron which branches at a guanosine.
... an intron spliced from mLAT in transient transfection assays and viral ...COS-1 cells, and at 44 to 48 h posttransfection, total RNA, nuclear RNA, or cytoplas- mic RNA was isolated and analyzed by ... See full document
10
Herpes Simplex Virus Type 1 2-Kilobase Latency-Associated Transcript Intron Associates with Ribosomal Proteins and Splicing Factors
... During latency of herpes simplex virus type 1 in sensory neurons, the transcription of viral genes is restricted to the latency-associated transcripts ...The ... See full document
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Deacetylation of the Herpes Simplex Virus Type 1 Latency-Associated Transcript (LAT) Enhancer and a Decrease in LAT Abundance Precede an Increase in ICP0 Transcriptional Permissiveness at Early Times Postexplant
... Herpes simplex virus type 1 (HSV-1) is characterized by its ability to establish latency as an episome in neurons ...the latency-associated transcript ... See full document
6
Herpes Simplex Virus Type 1 Latently Infected Neurons Differentially Express Latency-Associated and ICP0 Transcripts
... tected ICP0 transcripts not only in the TG and the SCG, which were positive by ISH, but also in other latently infected struc- tures such as the spinal cord and the ...of ICP0 transcripts is due to the slow ... See full document
12
A Herpes Simplex Virus Type 1 Latency-Associated Transcript Mutant with Increased Virulence and Reduced Spontaneous Reactivation
... The herpes simplex virus type 1 (HSV-1) latency-associated transcript (LAT) gene is essential for efficient spontaneous reactivation of HSV-1 from ... See full document
10
A 348-base-pair region in the latency-associated transcript facilitates herpes simplex virus type 1 reactivation.
... in latency (11, 22, ...pseudorabies virus, and bovine herpesvirus lends support to such ...LAT intron is quite stable, the actual amount of active latent-phase transcription is drastically ... See full document
11
Physical characterization of the herpes simplex virus latency-associated transcript in neurons.
... 1194 Downloaded from http://jvi.asm.org/ on November 10, 2019 by guest RNA transfer Northern blot analysis was used to perform the physical characterization of the transcript expressed i[r] ... See full document
9
In Vivo Knockdown of the Herpes Simplex Virus 1 Latency-Associated Transcript Reduces Reactivation from Latency
... The ribozyme used in this study targets the 5= exon region of the LAT primary transcript for cleavage. Cleaving the RNA in this region would be predicted to decrease levels of the primary LAT, spliced LAT, and the ... See full document
10
ICP0 Is Required for Efficient Reactivation of Herpes Simplex Virus Type 1 from Neuronal Latency
... role does ICP0 play in the HSV-1 reactivation pro- cess? Latency in the herpesvirus field has long been defined as the absence of infectious virus in cells or tissues that ... See full document
10
Neuronal Subtype Determines Herpes Simplex Virus 1 Latency-Associated-Transcript Promoter Activity during Latency
... lishes latency in trigeminal ganglia (TG), while HSV-2 usually infects the genital epithe- lium and establishes latency in dorsal root ganglia (DRG) ...(15), type of sensations conveyed (16), ... See full document
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Novel Less-Abundant Viral MicroRNAs Encoded by Herpes Simplex Virus 2 Latency-Associated Transcript and Their Roles in Regulating ICP34.5 and ICP0 mRNAs
... the antisense strand of the 5 ⬘ UTR of the ...U2OS cells with the miR-II duplex with or without a miR-II- ...and ICP0 expression, ...Vero cells with HSV-2 strain 333-infected Vero ... See full document
10
The latency-associated transcript gene of herpes simplex virus type 1 (HSV-1) is required for efficient in vivo spontaneous reactivation of HSV-1 from latency.
... In both experiments, the decreased spontaneous reactivation rate of the LAT deletion mutant compared with the parental or rescued virus was statistically significant McKrae versus dLAT29[r] ... See full document
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