[PDF] Top 20 In Vivo Knockdown of the Herpes Simplex Virus 1 Latency-Associated Transcript Reduces Reactivation from Latency
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In Vivo Knockdown of the Herpes Simplex Virus 1 Latency-Associated Transcript Reduces Reactivation from Latency
... of latency. New Zealand White rabbits (2 to 3 kg) were inoculated with 1 ⫻ 10 5 to 2 ⫻ 10 5 PFU of virus per eye in a suspension of 25 l MEM with 5% ...prevent virus loss ... See full document
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The latency-associated transcript gene of herpes simplex virus type 1 (HSV-1) is required for efficient in vivo spontaneous reactivation of HSV-1 from latency.
... To overcome this, we have constructed a LAT deletion mutant in HSV-1 McKrae and studied the effect of this mutation on in vivo spontaneous reactivation in the rabbit ocular model of HSV-[r] ... See full document
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The herpes simplex virus type 1 latency-associated transcript gene regulates the establishment of latency.
... Medicine, 1 and Division of Infectious Diseases, Children’s Hospital Medical Center, 2 Cincinnati, Ohio Received 4 February 1997/Accepted 17 April 1997 Herpes simplex virus type 1 ... See full document
9
In vivo deletion analysis of the herpes simplex virus type 1 latency-associated transcript promoter.
... During herpes simplex virus latency, transcripts accumulate from a single transcription unit of the viral ...these latency-associated transcripts (LAT) has been located, ... See full document
7
In vivo and in vitro reactivation impairment of a herpes simplex virus type 1 latency-associated transcript variant in a rabbit eye model.
... In the rabbit eye model, as in the mouse eye model (13, 27), the major latency-related phenotypic differences be- tween the LAT+ and LAT- viruses are (i) a less efficient reactivation of[r] ... See full document
5
Herpes Simplex Virus Type 1 Latency-Associated Transcript Reduces Human Neuroblastoma Cell Proliferation
... genes transcript levels by REST showed while the expression of cell cycle controller genes like EP300, P15, RBL1 and RBL2 were increased significantly, the cell cycle promoting genes like Mapk-1 indicated ... See full document
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The Latency-Associated Transcript Gene Enhances Establishment of Herpes Simplex Virus Type 1 Latency in Rabbits
... infection, latency, and spontaneous reactiva- ...spontaneous reactivation with the McKrae strain of HSV-1. Latency is assumed to have been established by 28 days ... See full document
7
A 348-base-pair region in the latency-associated transcript facilitates herpes simplex virus type 1 reactivation.
... and reactivation effects specific to ...the reactivation phenotype within the primary LAT ...tion transcript termination signal inserted at various sites along the primary transcript, we ... See full document
11
A Herpes Simplex Virus Type 1 Latency-Associated Transcript Mutant with Increased Virulence and Reduced Spontaneous Reactivation
... neous reactivation, the region ...taneous reactivation, but the effects of this must not be ...spontaneous reactivation possible in the rabbit ...spontaneous reactivation in the ...spontaneous ... See full document
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Neuronal Subtype Determines Herpes Simplex Virus 1 Latency-Associated-Transcript Promoter Activity during Latency
... mostly associated with hair or encapsulated mechanoreceptor structures in the dermis ...in vivo is consistent with data from our microfluidic ...and latency rather than the localization of the ... See full document
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Herpes simplex virus type 1 latency-associated transcription unit promotes anatomical site-dependent establishment and reactivation from latency.
... Quantitative analysis of establishment function demon- strated that the LATs- mutant KOS/62 established latent infection in 87% fewer trigeminal ganglionic neurons than did KOS/1 (LATs+)[r] ... See full document
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Evidence that the Herpes Simplex Virus Type 1 ICP0 Protein Does Not Initiate Reactivation from Latency In Vivo
... in vivo (42, ...exits latency can be quantified in the absence of infectious virus ...tion from latency in ...in vivo (as assayed by infectious virus production), and the ... See full document
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Two open reading frames (ORF1 and ORF2) within the 2.0-kilobase latency-associated transcript of herpes simplex virus type 1 are not essential for reactivation from latency.
... Expression of herpes simplex virus type 1 latency-associated transcripts in the trigeminal ganglia of mice during acute infection and reactivation of latent infection. Expression of herp[r] ... See full document
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Interactions between Herpesvirus Entry Mediator (TNFRSF14) and Latency-Associated Transcript during Herpes Simplex Virus 1 Latency
... proteins herpes simplex virus (HSV) uses for attachment/en- ...Interestingly, latency-associated transcript (LAT), the only viral gene consistently expressed during neuronal ... See full document
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Herpes Simplex Virus Type 1 Latency-Associated Transcript Gene Promotes Neuronal Survival
... Sawtell, J. Virol. 71:5432–5440, 1997). To further investigate how LAT functions, a 1.9-kb deletion that includes the entire LAT promoter and 827 bp of the 5 ⴕ end of the primary LAT mRNA was introduced into strain 17syn ... See full document
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The 2.2-Kilobase Latency-Associated Transcript of Herpes Simplex Virus Type 2 Does Not Modulate Viral Replication, Reactivation, or Establishment of Latency in Transgenic Mice
... expressed from a transgene, cannot function in ...a transcript would fail to function in trans in an antisense capacity, regardless of whether it is derived from the viral or the host ...encoded ... See full document
7
Herpes Simplex Virus Latency-Associated Transcript Sequence Downstream of the Promoter Influences Type-Specific Reactivation and Viral Neurotropism
... During latency, HSV-1 and HSV2-LAT-S1 did not re- activate ...lasting 1 to 2 days, similar in character to recurrences produced by HSV-2, HSV2-LAT-P1, and ...gressed from a single lesion to ... See full document
9
Identification of Herpes Simplex Virus Type 1 Latency-Associated Transcript Sequences That both Inhibit Apoptosis and Enhance the Spontaneous Reactivation Phenotype
... the reactivation phenotype and therefore add ad- ditional strong support for the hypothesis that LAT’s antiapo- ptosis activity is functionally related to its ability to enhance the reactivation ... See full document
6
The herpes simplex virus latency-associated transcript is spliced during the latent phase of infection.
... portion of spliced LAT seen in mouse sensory nerve ganglia latently infected with the McKrae, 17syn+, and Maclntyre strains of HSV-1 with that from mice and rabbits infected with the KOS[r] ... See full document
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The Herpes Simplex Virus Type 1 Latency-Associated Transcript (LAT) Enhancer/rcr Is Hyperacetylated during Latency Independently of LAT Transcription
... domain associated with modified histones typical of euchromatin, while the lytic gene regions would be contained within transcriptionally nonpermissive do- mains, similar to cellular ...of latency and ... See full document
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