[PDF] Top 20 Magnetization Transfer Histogram Analysis of the Cervical Cord in Patients with Multiple Sclerosis

... entire cervical cord) were used for the axial ...in cord volume, each histogram was nor- malized by dividing the height of each bin by the total number of pixels ...normalized histogram ... See full document

... spinal cord lesions in MS (7, 12), while some preliminary studies, but not all (5, 17), have found that MT-GE (18) and fast-STIR (3) sequences may offer im- proved ...spinal cord abnormalities (3, 7), we ... See full document

... vical cord from each patient were first reformatted in the axial plane and resampled to 1-mm section ...the cord surface and cord centerline (Fig ...the cord centerline was manually provided ... See full document

... 11 patients (seven women and four men; age range, 23–51 years; mean age, ...All patients were recruited from the Compre- hensive Multiple Sclerosis Center at our institution and were under the ... See full document

... Image analysis was performed by a validated active surface method [2] using the Jim software package ...whole cervical cord (C1 to C7) was mea- sured ...Spinal cord volume was normalized by ... See full document

... MS patients (P ⫽ ...(GLM) analysis was performed to test significant differences between NCs and MS patients and specific MS disease subtypes in which the age was entered as a covariate and, due to ... See full document

... MTR histogram of each tissue type was then generated, and the peak height was nor- malized by dividing each histogram frequency value (ie, the total number of voxels with a certain MTR value) by the total ... See full document

... plot analysis can also aid in the char- acterization of white matter ...trauma patients were imaged acutely or subacutely (at 5 to 11 days after injury), when processes such as wallerian degeneration and ... See full document

... nal cord. Nevertheless, because only a minority of MS patients have significant involvement of the spinal cord, this may represent only a minor limi- ...spinal cord involvement in MS pa- ... See full document

... and magnetization transfer (with and without MT saturation pulses) images from eighteen patients with relapsing-remitting MS and 18 age-matched healthy control ...MTR histogram parameters, ... See full document

... with multiple sclerosis in comparison with healthy people, have some abnormalities, such as torticollis, forward head, and ...these patients. 80% of patients with MS suffer from fatigue and ... See full document

... of patients enrolled in a long-term NIH-funded study to quantitatively evaluate MR lesion burden in persons with ...Ten patients had chronic- progressive MS (mean duration of disease, ...Two patients ... See full document

... MTR analysis of a subject’s complete ...MS patients have shown that progressive brain atrophy occurs early in the disease and correlates with en- hancing lesion activity (21, ... See full document

... All patients had lesions in either one or two categories, and none had lesions from all three ...tion transfer ratio of another type of lesion in that same ...correlation analysis was per- formed on ... See full document

... MTR histogram analysis of the BT and NABT are not significantly correlated with the cor- responding quantities from D ¯ and FA ...DT histogram metrics are strongly correlated with T2 and T1 LV, ... See full document

... tographic analysis technique ...CIS patients, but with con- flicting results (1, 27, ...CIS patients with at least four T2 lesions, thus concentrating on a group with a high likelihood of developing ... See full document

... Thirteen patients (three men and 10 women) with clini- cally definite MS (25) were entered into the ...All patients had a relapsing-remitting ...the patients had taken immunosuppressive or ... See full document

... of magnetization transfer and the apparent enhancement of lesions on contrast-enhanced MR images in patients with multiple ...20 patients with relapsing-remitting mul- tiple ... See full document

... Acknowledgments and disclosure: This work was funded by the Medical Research Council, the Chang Gang Memorial Hospital (project CM- RPG4A0124), the European Neurological Society, and the University of Nottingham. The ... See full document

... of multiple sclerosis lesions identified on unenhanced T1-weighted images and their corresponding magnetization transfer ...17 patients with multiple sclerosis were ...The ... See full document