[PDF] Top 20 Modelling multiple thresholds in meta-analysis of diagnostic test accuracy studies

... several studies reported more than one threshold and the corresponding values of sensitivity and specificity, and also the thresholds were provided (see for example ...bivariate meta-analysis ... See full document

... for meta-analysis of diagnostic test accuracy studies require relatively complex bivariate statistical models which can be a barrier for ...make analysis tool creation ... See full document

... in test-thresholds [1,7], as well as contain a certain amount of heterogeneity ...of diagnostic tests in a more careful ...the meta-analysis of sensitivity and specificity are still an ... See full document

... the analysis of SROC ...a diagnostic accuracy parameter which connects the ...the diagnostic accuracy parameter to become a ran- dom ...curve modelling and is compared to other ... See full document

... case-control studies are often healthy per- sons, whereas controls in consecutive studies are in fact suspected ...consecutive studies. Of four consecutive studies assessing PCR in blood, one ... See full document

... of test under evaluation and the total number of studies in- cluded in the ...primary studies within one meta-analysis for each included ...one meta-analysis per review ... See full document

... This paper focused on bivariate random-effects models for meta-analysis of diagnostic test accuracy. Attention is paid to the presence of errors affecting the measures of ... See full document

... and Meta-DiSc ...the accuracy of the diagnostic test ...among studies was recorded by I 2 , the potential source of heterogeneity was investigated by sensitivity ana- lysis and ...the ... See full document

... the accuracy measures in the same way as they affect the effect of ...the test either the sensitivity or the specificity are more af- fected by selective publication than the DOR, and tests for publication ... See full document

... implements meta-regression using a generali- zation of Littenberg and Moses Linear model [8,13] weighted by inverse of the variance or study size or ...between studies can be esti- mated by different ... See full document

... cohort studies, case-control studies, and randomized controlled trials that evaluated the accuracy of PCT or P-SEP in plasma or serum (index test), when used to diagnose bacterial infection or ... See full document

... replacement test for ...blood test may be more appealing and result in higher ...strategy, studies need to be done on decliners of FIT screening to determine their uptake in an alternative screen via ... See full document

... five studies were excluded during data extraction: three stud- ies were excluded because no relevant effect measure could be extracted, one study was excluded because only patients with metabolic acidosis were ... See full document

... Future studies of PET for the evaluation of glioma relapse should use prospective designs, focus on clinically relevant patient populations treated with standardized protocols, and avoid po- tential biases in ... See full document

... some studies, the numbers were not provided per se but it was possible to extract them from other manuscript data ...primary studies. Studies that reported only mean values of nNO were not included ... See full document

... 1.841(0.615). The test for the significance of the covari- ance between α i and ξ i in the MREM approach is not sig- nificant (likelihood ratio = 0.999, p-value = 0.317), and hence there is no indication for the ... See full document

... eligible studies and extracted the data from full papers of eligible ...the meta-data tables of diagnostic test accuracies of each imaging ...data analysis and ... See full document

... all studies and therefore selective reporting could be ...on meta-analysis of reported ...of multiple thresholds per study, several methods have been proposed to synthesise results from ... See full document

... for modelling within study variability are biased, we only investigated methods that use a binomial ...in meta-analysis of diagnostic accuracy ...of studies; 2) magnitude of ... See full document

... a diagnostic accuracy meta-analysis comparing the use of the Tourniquet Test (TT) to a laboratory assay standard (ELISA) for making a diagnosis of dengue ...16 studies with ... See full document