[PDF] Top 20 A Mutation in UL15 of Herpes Simplex Virus 1 That Reduces Packaging of Cleaved Genomes
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A Mutation in UL15 of Herpes Simplex Virus 1 That Reduces Packaging of Cleaved Genomes
... the cleaved vJB27 viral DNA was packaged, lysates of cells infected with vJB27, vJB28, and HSV-1(F) were incu- bated in the presence or absence of DNase before viral DNA ... See full document
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Packaging of Genomic and Amplicon DNA by the Herpes Simplex Virus Type 1 UL25-Null Mutant KUL25NS
... The herpes simplex virus type 1 (HSV-1) mutant KUL25NS, containing a null mutation within the UL25 gene, was isolated and characterized by McNab and coworkers ...into ... See full document
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DNA Cleavage and Packaging Proteins Encoded by Genes UL28, UL15, and UL33 of Herpes Simplex Virus Type 1 Form a Complex in Infected Cells
... and packaging of newly synthesized herpesvi- rus DNA is a highly conserved process occurring late in viral ...DNA genomes accumulate in cell nuclei as head-to-tail concatemers which are subsequently ... See full document
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Proteolytic Cleavage of the Amino Terminus of the UL15 Gene Product of Herpes Simplex Virus Type 1 Is Coupled with Maturation of Viral DNA into Unit-Length Genomes
... point mutation was incorporated (underlined); a 1,192-bp product was amplified with the primer 5⬘-CCT CAC CGT GGG CGG CGA TG-3⬘, which contains a point mutation, and the primer 5⬘-TAT AAC AAG AAC AGG CCG ... See full document
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Herpes Simplex Virus Type 1 Portal Protein UL6 Interacts with the Putative Terminase Subunits UL15 and UL28
... Herpes simplex virus type 1 (HSV-1) DNA is packaged into a preassembled icosahedral capsid, referred to as the procap- sid, within the cell nucleus (28, 29, ...is cleaved into ... See full document
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In Vivo Knockdown of the Herpes Simplex Virus 1 Latency-Associated Transcript Reduces Reactivation from Latency
... the genomes through the use of gene editing or ...to mutation/deletion strategies, especially for genomes of viruses like the herpesviruses that possess a high density of cis-acting genetic elements ... See full document
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Linker Insertion Mutations in the Herpes Simplex Virus Type 1 UL28 Gene: Effects on UL28 Interaction with UL15 and UL33 and Identification of a Second-Site Mutation in the UL15 Gene That Suppresses a Lethal UL28 Mutation
... of herpes simplex virus type 1 (HSV-1) is one of seven viral proteins required for the cleavage and packaging of viral ...with UL15 and UL33 to form a protein complex ... See full document
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Analysis of Herpes Simplex Virus Type 1 DNA Packaging Signal Mutations in the Context of the Viral Genome
... Table 1) confirmed and extended our previous obser- vations made using the amplicon assay ...and packaging. The four mutated fragments that supported generation of virus progeny, c1, c3, and c4 ... See full document
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Structural Characterization of the UL25 DNA-Packaging Protein from Herpes Simplex Virus Type 1
... DNA genomes as high-molecular-weight concatemers which are subsequently cleaved into unit-length genomes by a complex mechanism that is tightly coupled to DNA insertion into a preformed capsid ... See full document
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Effects of Mutations within the Herpes Simplex Virus Type 1 DNA Encapsidation Signal on Packaging Efficiency
... cleavage packaging signals has employed two principal ...functional packaging signals are present, it is encapsi- dated in the form of long concatemeric molecules consisting of head-to-tail repeats of the ... See full document
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Herpes Simplex Virus DNA Packaging without Measurable DNA Synthesis
... lane 1 with lanes 2, 3, and 15), which presumably derives from input ...DNA packaging was measurable for ...tsProt.A packaging oc- curred (lane 6), as expected from the data in ...type virus, ... See full document
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Structure and origin of defective genomes contained in serially passaged herpes simplex virus type 1 (Justin).
... de The, ed., 1065 Downloaded from http://jvi.asm.org/ on November 10, 2019 by guest Restriction enzyme and hybridization analyses have revealed that high-density DNA prepared from passag[r] ... See full document
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Herpes Simplex Virus DNA Cleavage and Packaging: Association of Multiple Forms of UL15-Encoded Proteins with B Capsids Requires at Least the UL6, UL17, and UL28 Genes
... proteolytically cleaved during the cleavage and packaging reaction (8, 16, ...DNA packaging are properly ...and packaging reac- tion, it could also serve to coordinate the onset of DNA cleav- ... See full document
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Characterization of ICP6::lacZ insertion mutants of the UL15 gene of herpes simplex virus type 1 reveals the translation of two proteins.
... of UL15 gene products by using an a-UL15 polyclonal antibody raised against an MBP-UL15 exon 2 fusion protein as described in Materials and ...full-length UL15 protein of 735 aa. When M-3 ... See full document
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An Enhanced Packaging System for Helper-Dependent Herpes Simplex Virus Vectors
... Herpes simplex virus (HSV) is a neurotropic herpesvirus that can establish lifelong infections in its human host through latent maintenance in the ganglia of sensory ...The virus is relatively ... See full document
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Phenotypic Suppression of a Herpes Simplex Virus 1 ICP27 Mutation by Enhanced Transcription of the Mutant Gene
... the virus stocks shown were plated on Vero cells, and the cultures were incubated in medium containing 1% (vol/vol) human serum (MP Biomedicals) to neutralize cell-free ... See full document
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Epigenetic Modulation of Gene Expression from Quiescent Herpes Simplex Virus Genomes
... of herpes simplex virus to persist in cells depends on the extent of viral-gene expression, which may be controlled by epigenetic ...viral genomes, although the levels of tk and gC RNA were ... See full document
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ATP Depletion Blocks Herpes Simplex Virus DNA Packaging and Capsid Maturation
... capsids were then centrifuged through a sucrose cushion to sep- arate them from soluble polypeptides, and the resulting pellet was blotted for the presence of ICP35. As can be seen in Fig. 3C, samples which had not been ... See full document
10
Herpes Simplex Virus Type 1 Latency-Associated Transcript Reduces Human Neuroblastoma Cell Proliferation
... Herpes simplex virus type 1 latency associated transcript is plentifully expressed through virus latency. Extensive investigations have explored the LAT features while most of their ... See full document
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Quantitation of Latent Varicella-Zoster Virus and Herpes Simplex Virus Genomes in Human Trigeminal Ganglia
... of the desired genes. Additional dilutions within that range were analyzed for plasmids bearing the genes for gB, ORF 62, and gG1 to better delineate the sensitivity limits at the low ends of the standard curves. ... See full document
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