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[PDF] Top 20 Neutralization of human immunodeficiency virus type 1 by complement occurs by viral lysis.

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Neutralization of human immunodeficiency virus type 1 by complement occurs by viral lysis.

Neutralization of human immunodeficiency virus type 1 by complement occurs by viral lysis.

... Requirement of C2 and terminal complement components for antibody-mediated RT release % of maximal detergent-releasable RT activity Serum used as complement source' No of expts Antibody [r] ... See full document

5

Human immunodeficiency virus type 1 mutants that escape neutralization by human monoclonal antibody IgG1b12. off.

Human immunodeficiency virus type 1 mutants that escape neutralization by human monoclonal antibody IgG1b12. off.

... The viral pellet was lysed with Nonidet P-40 detergent (1% vol/vol), and the monomeric gp120-MAb complexes were captured on 96-well plates coated with D7324 as described ...the viral pellets and the ... See full document

6

Cellular and Viral Specificities of Human Immunodeficiency Virus Type 1 Vif Protein

Cellular and Viral Specificities of Human Immunodeficiency Virus Type 1 Vif Protein

... that occurs specifically in nonper- missive human cells (22, 32), the current data strongly indicate that this increases the infectivity of HIV-1 more than 100-fold but has no effect on the ... See full document

6

Introduction of Exogenous Epitopes in the Variable Regions of the Human Immunodeficiency Virus Type 1 Envelope Glycoprotein: Effect on Viral Infectivity and the Neutralization Phenotype

Introduction of Exogenous Epitopes in the Variable Regions of the Human Immunodeficiency Virus Type 1 Envelope Glycoprotein: Effect on Viral Infectivity and the Neutralization Phenotype

... to neutralization by the anti-HA MAb used ...of viral particles, our results suggest that primarily the unprocessed Env forms were recognized by the anti-FLAG MAb and that this binding did not lead to ... See full document

11

Antibody to adhesion molecule LFA-1 enhances plasma neutralization of human immunodeficiency virus type 1.

Antibody to adhesion molecule LFA-1 enhances plasma neutralization of human immunodeficiency virus type 1.

... the virus susceptible to lysis by complement in the presence of anti-CD55 and anti-CD59 antibodies, while virus grown in cells not expressing these surface molecules was insensitive to com- ... See full document

5

Neutralization sensitivity of human immunodeficiency virus type 1 is determined in part by the cell in which the virus is propagated.

Neutralization sensitivity of human immunodeficiency virus type 1 is determined in part by the cell in which the virus is propagated.

... Resistance of primary isolates of human immunodeficiency virus type 1 to neutralization by soluble CD4 is not due to lower affinity with the viral envelope glycoprotein gpl20.. Human imm[r] ... See full document

8

Role of Complex Carbohydrates in Human Immunodeficiency Virus Type 1 Infection and Resistance to Antibody Neutralization

Role of Complex Carbohydrates in Human Immunodeficiency Virus Type 1 Infection and Resistance to Antibody Neutralization

... Another way to investigate the importance of glycans in HIV-1 infection is to treat virus with glycosidases. However, despite the sensitivity of soluble Env proteins to these en- zymes, studies until now ... See full document

19

Nascent human immunodeficiency virus type 1 reverse transcription occurs within an enveloped particle.

Nascent human immunodeficiency virus type 1 reverse transcription occurs within an enveloped particle.

... gels), HIV-1 DNA was extracted and analyzed by PCR. (A) Viral DNA was amplified with the strong-stop (R-U5) primer pair M667/AA55. (B) Viral DNA was amplified with the first-strand (gag) primer pair ... See full document

8

Efficient lysis of human immunodeficiency virus type 1-infected cells by cytotoxic T lymphocytes.

Efficient lysis of human immunodeficiency virus type 1-infected cells by cytotoxic T lymphocytes.

... cessed viral antigens derived from intracellular proteins, virus- specific CTL are thought to inhibit virus replication by lysing infected cells before infectious virions can be ...in viral ... See full document

8

Neutralization Escape Variants of Human Immunodeficiency Virus Type 1 Are Transmitted from Mother to Infant

Neutralization Escape Variants of Human Immunodeficiency Virus Type 1 Are Transmitted from Mother to Infant

... simian-human immunodeficiency virus ...simian-human immunodeficiency virus ...of virus, and one that is sensitive to neutralization by these antibodies (2, 10, 17), ... See full document

11

Coreceptor Utilization by Human Immunodeficiency Virus Type 1 Is Not a Primary Determinant of Neutralization Sensitivity

Coreceptor Utilization by Human Immunodeficiency Virus Type 1 Is Not a Primary Determinant of Neutralization Sensitivity

... pro- virus (28) contains a BglII-BglII deletion within the envelope gene and a substitution of the viral nef gene with a cDNA encoding the murine ...simian virus 40 ori was subsequently introduced ... See full document

5

Augmentation of virus secretion by the human immunodeficiency virus type 1 Vpu protein is cell type independent and occurs in cultured human primary macrophages and lymphocytes.

Augmentation of virus secretion by the human immunodeficiency virus type 1 Vpu protein is cell type independent and occurs in cultured human primary macrophages and lymphocytes.

... established human cell lines (23, 26, 32, 48, 52–54, ...on virus replication in MDM, which was func- tionally complemented by Vpr, an up to 1,000-fold Vpu-medi- ated enhancement of virus replication ... See full document

13

Resistance of human immunodeficiency virus type 1 to neutralization by natural antisera occurs through single amino acid substitutions that cause changes in antibody binding at multiple sites.

Resistance of human immunodeficiency virus type 1 to neutralization by natural antisera occurs through single amino acid substitutions that cause changes in antibody binding at multiple sites.

... the neutralization of human immunodeficiency virus type 1 (HIV-1) by monoclonal antibodies have identified a number of targets on the HIV-1 envelope proteins gp120 ... See full document

7

Detachment of Human Immunodeficiency Virus Type 1 from Germinal Centers by Blocking Complement Receptor Type 2

Detachment of Human Immunodeficiency Virus Type 1 from Germinal Centers by Blocking Complement Receptor Type 2

... of viral particles released from FDC has not been investigated in ...experiments, virus capture assays (7) revealed that C3d and IgG are the most abundant proteins detected in the viral envelope of ... See full document

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Distinction of human immunodeficiency virus type 1 neutralization and infection enhancement by human monoclonal antibodies to glycoprotein 120

Distinction of human immunodeficiency virus type 1 neutralization and infection enhancement by human monoclonal antibodies to glycoprotein 120

... that complement receptors on T lymphoid cells and Fc receptors for IgG (Fc gamma R) on monocytic cells are required for enhanced infection by antibody-complexed ...IgG human monoclonal antibodies (HMAbs) ... See full document

7

Human Immunodeficiency Virus Type 1 Superinfection Occurs despite Relatively Robust Neutralizing Antibody Responses

Human Immunodeficiency Virus Type 1 Superinfection Occurs despite Relatively Robust Neutralizing Antibody Responses

... pseudotyped viral particles, plasmid DNA was transfected into 293T cells along with an envelope-deficient HIV-1 subtype A proviral plasmid, Q23 ⌬ env, as described previously ... See full document

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Neutralization Profiles of Primary Human Immunodeficiency Virus Type 1 Isolates in the Context of Coreceptor Usage

Neutralization Profiles of Primary Human Immunodeficiency Virus Type 1 Isolates in the Context of Coreceptor Usage

... of human immunodeficiency virus type 1 (HIV-1) which have only been carried in vitro in peripheral blood mononuclear cells (primary isolates) can be neutralized by antibodies, ... See full document

9

Antibody Binding Is a Dominant Determinant of the Efficiency of Human Immunodeficiency Virus Type 1 Neutralization

Antibody Binding Is a Dominant Determinant of the Efficiency of Human Immunodeficiency Virus Type 1 Neutralization

... bind virus particles in vitro is examined, are not exact prognostic indicators for neutraliza- tion potency either (7, 16, 32, ...in viral stocks (16, 32); (ii) the replication defec- tiveness of the vast ... See full document

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Potent Human Immunodeficiency Virus-Neutralizing and Complement Lysis Activities of Antibodies Are Not Obligatorily Linked

Potent Human Immunodeficiency Virus-Neutralizing and Complement Lysis Activities of Antibodies Are Not Obligatorily Linked

... patient virus rebounded upon escape to antibody 2G12 (27, ...rebounding virus had lost sensitivity to 2G12, virus isolates from all patients retained their sensitivities to 2F5 and ...but ... See full document

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Antibody Neutralization-Resistant Primary Isolates of Human Immunodeficiency Virus Type 1

Antibody Neutralization-Resistant Primary Isolates of Human Immunodeficiency Virus Type 1

... HIV type 1 variation in World Health Organization-sponsored vaccine evaluation sites: genetic screening, sequence analysis, and preliminary biological character- ization of selected viral ...of ... See full document

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