[PDF] Top 20 Normalizing glycosphingolipids restores function in CD4+ T cells from lupus patients
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Normalizing glycosphingolipids restores function in CD4+ T cells from lupus patients
... in T cells from patients with SLE. PBMCs from 5 SLE patients and 5 healthy donors were cultured for 7 days with ...NB-DNJ. Cells were labeled with anti-CD3/CD28 (1 μ g/ml) ... See full document
14
Hydroxychloroquine inhibits CD154 expression in CD4+ T lymphocytes of systemic lupus erythematosus through NFAT, but not STAT5, signaling
... during T-cell acti- vation [44, ...after T-cell activation in pediatric SLE patients and is also responsive for CD154 expression [3, 11, ...Jurkat cells. Cells were first treated with ... See full document
14
Defective response of CD4+T cells to retinoic acid and TGFβ in systemic lupus erythematosus
... Sle1a.1 lupus sus- ceptibility locus results in the production of activated and autoreactive CD4 + T cells, and in a reduction of the Treg pool ...Sle1a.1 CD4 + T cells ... See full document
15
Defective BTLA functionality is rescued by restoring lipid metabolism in lupus CD4+ T cells
... systemic lupus erythematosus (SLE), by limiting T cell activation. B and T lymphocyte attenuator (BTLA) is an inhibitory receptor, similar to cytotoxic T lymphocyte–associated protein 4 ... See full document
15
Are CD4+CD25 Foxp3+cells in untreated new onset lupus patients regulatory T cells?
... cells is sufficient to generate Tregs in vitro. In humans, Foxp3 deficiency also leads to a systemic autoimmune disease known as IPEX (immune dysregulation, polyendocrinopathy, enteropathy X-linked syndrome). It ... See full document
9
Expansion of regulatory GITR+CD25low/ CD4+ T cells in systemic lupus erythematosus patients
... autoreactive CD4 + T cells with the removal of Tregs ...circulating CD4 + CD25 low/- GITR + Treg cells and a correlation be- tween their number and inactive disease, suggesting that ... See full document
15
Characterization of CD3+CD4-CD8- (double negative) T cells in patients with systemic lupus erythematosus (SLE)
... human T, B cells and thymocytes in the early steps of activation; its molecular mass is 28 to 34 kDa under reducing ...in T cell activation such as heat shock (Barclay, ...hematopoietic cells ... See full document
210
Lipids rule: resetting lipid metabolism restores T cell function in systemic lupus erythematosus
... raft function (8, ...lymphocytes from SLE ...production from autoimmune lymphocytes (8, 9, ...in T cells from patients with rheumatic diseases has remained ...autoimmune ... See full document
5
The apoptosis 1/Fas protein in human systemic lupus erythematosus
... mononuclear cells and on lymphocytes activated in vitro using flow cytometry and the monoclonal antibody ...B cells and both CD4+ and CD8+ T lymphocyte populations obtained from ... See full document
7
Original Article Bauduanjin exercise restores T cell function in man with heroin addicts by decreasing CD4 CD25 Foxp3 regulatory T cells
... heroin patients (all males) in Baduanjin exer- cise group, and 27 healthy donors(all males) without active infections or inflammatory dis- eases participated in this study after giving informed ...All ... See full document
8
Characterization of CD3+CD4-CD8- (double negative) T cells in patients with systematic lupus erythematosus (SLE).
... DN T cells in patients with SLE, suggest a regulatory role for all or a subset of the DN T cell ...the function o f conventional (CD4+/CD8+) T cells and B ... See full document
212
Impaired translational response and increased protein kinase PKR expression in T cells from lupus patients
... blood T cells results in a rapid and substantial rise in translation rates and proliferation, but proliferation in response to mitogen stimulation is impaired in systemic lupus erythematosus ...in ... See full document
9
Chronic lymphocytic leukemia T cells show impaired immunological synapse formation that can be reversed with an immunomodulating drug
... B cells induce defective immunological synapse formation in healthy allogeneic T cells by direct cell ...Healthy T cells (T) were cocultured for 48 h with either healthy ... See full document
12
Role of Cholesterol in Human Immunodeficiency Virus Type 1 Envelope Protein-Mediated Fusion with Host Cells
... Preparation of detergent-resistant membrane (DRM) fractions. Plasma mem- brane rafts were obtained as previously described (52). Briefly, primary lympho- cytes were left untreated at 37°C or incubated with 10 g of ... See full document
12
Therapeutic Effect of Ergotope Peptides on Collagen-Induced Arthritis by Downregulation of inflammatory and Th1/Th17 Responses and Induction of Regulatory T Cells
... helper T cells (Th) 1 and 17 and regulatory T cells (Treg) is broken in ...peptides from 25 over- lapping peptides derived from the interleukin 2 receptor (IL-2R) α chain, and ... See full document
13
Feasibility of up-regulating CD4+CD25+ Tregs by IFN-γ in myasthenia gravis patients
... and function of CD4 + CD25 + ...its function [8], these molecules are not specific for CD4 + CD25 + ...and function of CD4 + CD25 + Tregs [9, ...and function of CD4 ... See full document
10
IL 12 upregulates TIM 3 expression and induces T cell exhaustion in patients with follicular B cell non Hodgkin lymphoma
... by T and NK ...in patients with any one of a variety of ...in patients with follicular B cell non-Hodgkin lymphoma (FL), those treated with IL-12 showed a lower response rate, suggest- ing that IL-12 ... See full document
13
Thymic Stromal Lymphopoietin promoted CD4 CD25 T cells differentiation isolated from the thymus of patients with Myasthenia Gravis to CD4 CD25 Regulatory T Cells in vitro
... of CD4+ T cells called regulatory T ...Treg cells are a subpopulation of T cells that act to suppress activation of other immune cells and thereby maintain immune ... See full document
16
The characterisation of a T cell response to human rhinovirus
... If CD4 Thl cells do contribute to the protection against HRV infection in vivo, the identification of cross reactive serotypes and epitopes may provide a means of boosting the cellular immunity and possibly ... See full document
226
Dominant negative IKZF1 mutations cause a T, B, and myeloid cell combined immunodeficiency
... in patients with a B cell immune deficiency mimicking common variable ...unrelated patients with a novel early-onset combined immunodeficiency associated with de novo germline IKZF1 heterozygous mutations ... See full document
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