[PDF] Top 20 Nuclear Export and Expression of Human T-Cell Leukemia Virus Type 1 tax/rex mRNA Are RxRE/Rex Dependent
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Nuclear Export and Expression of Human T-Cell Leukemia Virus Type 1 tax/rex mRNA Are RxRE/Rex Dependent
... Type 1 tax/rex mRNA Are RxRE/Rex Dependent ...USA Human T-cell leukemia virus type 1 (HTLV-1) is a complex ... See full document
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Multimer Formation Is Not Essential for Nuclear Export of Human T-Cell Leukemia Virus Type 1 Rextrans-Activator Protein
... HTLV-1 Rex that is required for biological ...partial Rex activity by fusing our inactive mutants in frame to the heterologous GCN4 leucine zipper ...standard Rex trans-activation assay, which ... See full document
10
Phosphorylation regulates human T cell leukemia virus type 1 Rex function
... phosphorylated Rex-1, but also assign phosphorylation to site-specific residues by peptide sequencing using tandem mass ...that Rex-1 is phosphorylated predominantly on serine and threonine ... See full document
11
Functional Domain Structure of Human T-Cell Leukemia Virus Type 2 Rex
... of Rex-1. However, a recent study that examined sequences in HIV-1 Rev lying carboxy terminal to the protein’s NES revealed that this region is also required for efficient binding to CRM1, thus ... See full document
12
Inhibition of human T-cell leukemia virus type 2 Rex function by truncated forms of Rex encoded in alternatively spliced mRNAs.
... Three mRNA species encoding the x-III open reading frame are expressed in human T-cell leukemia virus type 2 (HTLV-2)-infected ...An mRNA composed of exons ... See full document
9
Human T-cell leukemia virus type 2 Rex inhibits pre-mRNA splicing in vitro at an early stage of spliceosome formation.
... adding Rex to commitment complexes, formed for increasing amounts of time by preincubating RNA substrates together with HeLa nuclear extract in the absence of ...that Rex can- not abrogate splicing ... See full document
8
Rat CRM1 Is Responsible for the Poor Activity of Human T-Cell Leukemia Virus Type 1 Rex Protein in Rat Cells
... the mRNA for the Tax/Rex protein is abundant ...that Rex may function poorly in rat ...of Rex in rat ...support Rex function efficiently because of its poor ability to induce ... See full document
11
Human T-Cell Leukemia Virus Type 1 Expressing Nonoverlapping Tax and Rex Genes Replicates and Immortalizes Primary Human T Lymphocytes but Fails To Replicate and Persist In Vivo
... down-regulating tax/rex mRNA expression at a posttranscrip- tional level (41, ...of Tax and Rex was proposed to be important for the virus to evade immune recognition in ... See full document
9
Human T-Cell Leukemia Virus Type 2 Rex Protein Increases Stability and Promotes Nuclear to Cytoplasmic Transport of gag/pol and env RNAs
... gene expression and low transfection efficiency of full-length proviral constructs into human T cells necessitate the use of ...spliced tax/rex ... See full document
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Human T-cell leukemia virus type II nucleotide sequences between env and the last exon of tax/rex are not required for viral replication or cellular transformation.
... mutant virus are capable of produc- tive infection, the stable transfectants were cocultivated with the BJAB cell ...Table 1). Syncytium formation is dependent on the efficient ... See full document
8
Rex transregulation of human T-cell leukemia virus type II gene expression.
... Deletion and substitution mutagenesis of the Rex11RE permitted identification of a small subregion within the larger element critically required for Rex-II responsiveness and further sug[r] ... See full document
10
Influence of human T-cell leukemia virus type I tax and rex on interleukin-2 gene expression.
... The X region of human T-cell leukemia virus type I (HTLV-I) encodes two proteins that regulate viral gene expression.. The tax protein is the product of the transactivator gene and has b[r] ... See full document
10
Involvement of Human CRM1 (Exportin 1) in the Export and Multimerization of the Rex Protein of Human T-Cell Leukemia Virus Type 1
... HIV type 1 Env protein in the presence of a functional Rex ...kit. Human anti-HIV antisera diluted 100-fold were added to the wells of the plate, and the plate was ...The cell lysates ... See full document
6
Transdominant repressors for human T-cell leukemia virus type I rex and human immunodeficiency virus type 1 rev function.
... Due to the multiva- lent transdominant capacity to inhibit both the HTLV-I rex and the HIV-1 rev gene function on both RNA target sequences (RxRE and RRE), the mutant protein encoded in [r] ... See full document
8
In vitro binding of human T-cell leukemia virus rex proteins to the rex-response element of viral transcripts.
... A rev/p-galactosidase fusion protein binds in vitro transcripts spanning the rev-responsive element of human immunodefi- ciency virus type 1 (HIV-1). 'ATG vectors' for regulated[r] ... See full document
7
The Rex proteins of human T-cell leukemia virus type II differ by serine phosphorylation.
... Endoproteinase digestion and phosphoamino acid analysis of HTLV-ll Rex indicated that p24'x has the same amino acid backbone as p26rx and that the larger apparent molecular size of p26'X[r] ... See full document
5
Secondary structure of the human T-cell leukemia virus type 1 rex-responsive element is essential for rex regulation of RNA processing and transport of unspliced RNAs.
... In these secondary structures, we identified a conserved sequence in the HTLV-related viruses HTLV-1, HTLV-2, and BLV, in the external region of stem-loop D (Fig. 7d), which was identifi[r] ... See full document
8
High-resolution mapping of the human T-cell leukemia virus type 1 Rex-binding element by in vitro selection.
... the Rex ARM are localized within these ...the Rex ARM, while the right half of the XBE, spanning residues 174 to 179 and 201 to 204, forms a sequence-specific TAR-like arginine-binding ... See full document
11
Human T-Cell Leukemia Virus Type 2 Rex Carboxy Terminus Is an Inhibitory/Stability Domain That Regulates Rex Functional Activity and Viral Replication
... active Rex-2 mutants, A157D and S158Term, led to increased pro- duction of p19 Gag as measured in the culture supernatant, ultimately increasing HTLV-2 infectious spread and HTLV-2- mediated cellular proliferation ... See full document
12
Phosphorylation regulates RNA binding by the human T-cell leukemia virus Rex protein.
... Human T-cell leukemia virus (HTLV) type II Rex protein binds specifically to RNA sequences of the HTLV long terminal repeat but poorly to the human immunodeficiency virus type 1 Rev-resp[r] ... See full document
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