[PDF] Top 20 Quantification of the Effects on Viral DNA Synthesis of Reverse Transcriptase Mutations Conferring Human Immunodeficiency Virus Type 1 Resistance to Nucleoside Analogues
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Quantification of the Effects on Viral DNA Synthesis of Reverse Transcriptase Mutations Conferring Human Immunodeficiency Virus Type 1 Resistance to Nucleoside Analogues
... on viral replication. No defect in DNA synthesis for viruses carrying the M41L ⫹ T215Y mutations could be detected either in endogenous RT reactions or following infection of unpre- treated P4 ... See full document
11
Effects of zidovudine-selected human immunodeficiency virus type 1 reverse transcriptase amino acid substitutions on processive DNA synthesis and viral replication.
... template DNA were ...10). DNA sequencing of the RT coding sequences confirmed the presence of the intended mutations in the appropriate plasmids and ruled out possible errors introduced during ... See full document
8
Hypersusceptibility to Substrate Analogs Conferred by Mutations in Human Immunodeficiency Virus Type 1 Reverse Transcriptase
... of viral RNA to double-stranded DNA by re- verse transcriptase (RT) is a defining step in the retroviral life cycle (8) and a key target of therapy for human immunodefi- ciency virus ... See full document
10
Insertions in the Reverse Transcriptase Increase both Drug Resistance and Viral Fitness in a Human Immunodeficiency Virus Type 1 Isolate Harboring the Multi-Nucleoside Reverse Transcriptase Inhibitor Resistance 69 Insertion Complex Mutation
... recombinant virus in these two different environments ...tance mutations has a debilitating effect on HIV-1 replication (and, consequently, viral fitness) while conferring a selective ... See full document
7
Worldwide Evaluation of DNA Sequencing Approaches for Identification of Drug Resistance Mutations in the Human Immunodeficiency Virus Type 1 Reverse Transcriptase
... drug resistance mutations in the HIV-1 RT ...the effects of resis- tance mutations on viral drug susceptibility, and the fact that biological drug susceptibility assays are ... See full document
6
Mutations in the Primer Grip of Human Immunodeficiency Virus Type 1 Reverse Transcriptase Impair Proviral DNA Synthesis and Virion Maturation
... the viral genome is schematically represented on the left of each ...R-U5 DNA corresponding to the earliest stage of reverse transcription (A); 39PBS/MA (39PBS, 59-ACTTGAAAGCGA AAGTAAAGC-39; and MA, ... See full document
5
Resistance to Nucleoside Analog Reverse Transcriptase Inhibitors Mediated by Human Immunodeficiency Virus Type 1 p6 Protein
... of viral escape from selective pressure described herein could also correspond to the general mecha- nism of drug target gene dosing associated with antimicrobial drug resistance in bacteria, parasites, and ... See full document
10
Multiple effects of mutations in human immunodeficiency virus type 1 integrase on viral replication.
... a DNA copy of the human immunodeficiency virus type 1 (HIV-1) genome into a chromosome of an infected cell is a pivotal step in virus ...the virus-encoded ... See full document
8
Human Immunodeficiency Virus Type 1: Resistance to Nucleoside Analogues and Replicative Capacity in Primary Human Macrophages
... Most resistance mutations in HIV-1 have been found to be associated with some loss in ...such mutations could be partially com- pensated for by high concentrations of dNTPs, we have com- pared ... See full document
11
Increased Misincorporation Fidelity Observed for Nucleoside Analog Resistance Mutations M184V and E89G in Human Immunodeficiency Virus Type 1 Reverse Transcriptase Does Not Correlate with the Overall Error Rate Measured In Vitro
... in viral isolates bearing the M184V mutation as ...two mutations on error ...individual mutations increased polymerase fidelity slightly while a com- bination of the two led to a slight decrease in ... See full document
7
Reverse Transcriptase Inhibitors Can Selectively Block the Synthesis of Differently Sized Viral DNA Transcripts in Cells Acutely Infected with Human Immunodeficiency Virus Type 1
... of human immunodeficiency virus type 1 (HIV-1) reverse transcription by inhibitors of reverse transcriptase (RT) occurred most efficiently when the expected ... See full document
8
The Human Immunodeficiency Virus Type 1 Nonnucleoside Reverse Transcriptase Inhibitor Resistance Mutation I132M Confers Hypersensitivity to Nucleoside Analogs
... LexA DNA-binding domain (the bait) and p51 is fused to Gal4AD (the ...same mutations in each subunit was ...the effects of I132M in each of the subunits on RT dimerization, we performed a ... See full document
8
The Impact of Multidideoxynucleoside Resistance-Conferring Mutations in Human Immunodeficiency Virus Type 1 Reverse Transcriptase on Polymerase Fidelity and Error Specificity
... of mutations by wild-type and multidrug-resistant HIV-1 ...of mutations generated during the gap fill-in DNA synthesis reaction, M13 templates from 117 plaques representing the ... See full document
6
Interaction of Reverse Transcriptase (RT) Mutations Conferring Resistance to Lamivudine and Etravirine: Effects on Fitness and RT Activity of Human Immunodeficiency Virus Type 1
... days 1, 4, 7, 11, and 14 postinfection, 200 l of culture supernatant was removed and replaced with 250 l of fresh ...competing viral variants was estimated by quantifying GFP and hisD sequences present ... See full document
6
Effects of Amino Acid Substitutions at Position 115 on the Fidelity of Human Immunodeficiency Virus Type 1 Reverse Transcriptase
... of mutations in which an A is substituted for another base in both transitions and ...during reverse transcription in vivo, RT in the DNA-depen- dent DNA synthesis mode (copying ... See full document
7
The M184V Mutation in the Reverse Transcriptase of Human Immunodeficiency Virus Type 1 Impairs Rescue of Chain-Terminated DNA Synthesis
... the reverse transcriptase (RT) of human immunodeficiency virus type ...AZT resistance are capable of removing the chain-terminating residue with much greater efficiency ... See full document
7
Involvement of Novel Human Immunodeficiency Virus Type 1 Reverse Transcriptase Mutations in the Regulation of Resistance to Nucleoside Inhibitors
... NAM 1 profile (40), may im- prove the efficacy of the ATP-mediated removal of the zidovu- dine or stavudine monophosphate from the terminated cDNA chain ...chance effects, or host factors such as HLA ... See full document
13
Mutations That Confer Resistance to Template-Analog Inhibitors of Human Immunodeficiency Virus (HIV) Type 1 Reverse Transcriptase Lead to Severe Defects in HIV Replication
... of viral resistance, is less likely to be a problem in the case of TRTIs caused by pertur- bation of critical functions intrinsic to HIV-1 ...whether mutations conferring ... See full document
5
Frequency of Mutations Conferring Resistance to Nucleoside Reverse Transcriptase Inhibitors in Human Immunodeficiency Virus Type 1 Infected Patients in Korea
... the viral enzymes reverse transcriptase (RT) and protease (PR) of human immunodeficiency virus (HIV) type 1 (HIV-1); both are encoded by the pol ...with ... See full document
7
Effects of Human Immunodeficiency Virus Type 1 Resistance to Protease Inhibitors on Reverse Transcriptase Processing, Activity, and Drug Sensitivity
... AZT resistance mutations, T215Y among them (1, ...AZT resistance mutations was not perceptible when the viral precursor molecules were cleaved by a PI-naive protease, maybe ... See full document
5
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