[PDF] Top 20 Quantifying Protein Function Specificity in the Gene Ontology
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Quantifying Protein Function Specificity in the Gene Ontology
... The most unique aspect of IC is that it is calculated from data. The strength of IC, however, doubles as a caveat: since it is data dependent, the IC of a par- ticular GO term may fluctuate from data set to da- ta set. ... See full document
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Gene Ontology consistent protein function prediction: the FALCON algorithm applied to six eukaryotic genomes
... each protein the probability of being member of that class is evaluated by the ...each protein may belong to one or multiple ...propagate function information through networks of protein ... See full document
9
A drug target slim: using gene ontology and gene ontology annotations to navigate protein-ligand target space in ChEMBL
... of protein target ...on protein molecular function, biological process and subcellular ...these protein targets. The ‘ ChEMBL protein target slim ’ provides a means of firstly ... See full document
7
Systematically characterizing and prioritizing chemosensitivity related gene based on Gene Ontology and protein interaction network
... of gene expression data and drug activity within the NCI 60 dataset ...of gene expression and 5-FU ...coupled gene expression and drug activity with bootstrap analysis to identify gene-drug ... See full document
12
Filtering Gene Ontology semantic similarity for identifying protein complexes in large protein interaction networks
... the ontology structure, the semantic specificity of a given term x can be measured by the path length from the root node to x passing through its ...semantic specificity from its ancestor a can be ... See full document
10
Neural development is dependent on the function of specificity protein 2 in cell cycle progression
... Animals were used under Institutional Animal Care and Use Committee and North Carolina State University regulations. Sp2 floxed mice were generated using homologous recombination. The targeting vector included a 3.2-kb ... See full document
10
Portable And Inexpensive Hemoglobin Testing Device Based On The Beer Lambert’s Law K. Saranya, P. Indira Priya Abstract PDF IJIRMET160203005
... that Gene Ontology and interactions between proteins can be used as a key to predict unknown protein-protein ...Detecting protein interactions by means of biology experiments are costly ... See full document
5
Network-based prediction and knowledge mining of disease genes
... analyzed protein-protein interactions using the Human Protein Reference Database (HPRD) [28] Release 9, which contained 9,616 proteins and 39,240 binary ...Disease Ontology [4] and the ... See full document
11
Predicting gene ontology annotations of orphan GWAS genes using protein-protein interactions
... a protein may not have the same function as its direct interacting partner, but may be similar to its neighbors-of-neighbors ...a protein can be reached through at-most n direct physical inter- ... See full document
13
Quantitative succinylome analysis in the liver of non-alcoholic fatty liver disease rat model
... including gene ontology annotation based classification; Wolfpsort based subcellular prediction; function enrichment; protein- protein interaction network construction and conserved ... See full document
11
Comparative genomics reveals the unique evolutionary status of Plasmodiophora brassicae and the essential role of GPCR signaling pathways
... NR protein database with the GO (Ashburner et ...The protein domain was predicted using the InterPro and Pfam ...a function to CDSs consisted of a minimum cut off of 30% identity and 70% coverage of ... See full document
15
Role of Autocleavage in the Function of a Type III Secretion Specificity Switch Protein in Salmonella enterica Serovar Typhimurium
... the protein translocases (middle substrates) and effectors (late substrates) (13–15) ...substrate specificity exhibit much longer needles, as these secretion machines are locked in a secretion mode that is ... See full document
8
Effect of hyperoside on cervical cancer cells and transcriptome analysis of differentially expressed genes
... comparing gene expression between the Hy and control ...74 gene ontology biological processes and 43 Kyoto Encyclopedia of Genes and Genomes pathways were ...the protein interaction network ... See full document
14
Proteomic analysis of protein purified derivative of Mycobacterium bovis
... Raw data were processed by Proteome Discoverer 1.4 using the Sequest algorithm and searched against the protein sequence database of Mycobacterium tubercu- losis Complex (June 2015, 6415 proteins). Search crite- ... See full document
8
IDOMAL: the malaria ontology revisited
... the ontology and, especially, would make it easier to design other ontol- ogies for vector-borne ...Management Ontology (VSMO) was published that covers the do- main of vector control ... See full document
6
Clinical Review: Gene based therapies for ALI/ARDS: where are we now?
... to gene-based ...for gene- based ...cell function, to strengthen lung defense mechanisms against injury, to speed clearance of infection and to enhance the repair process following ALI/ARDS have all ... See full document
12
Predicting Disease-Related Proteins Based on Clique Backbone in Protein-Protein Interaction Network
... So, gene ontology (GO) scoring is introduced to de- cide the final predictions of disease proteins according to the fact that genes associated with the same disor- der have significantly higher GO ... See full document
12
Large-scale development, characterization, and cross-amplification of EST–SSR markers in Chinese chive
... The 2553 SSRs were distributed among 2476 EST sequences, 626, 643, and 536 SSRs located in the CDS regions, 5' untranslated regions (5' UTRs), and 3' untranslated regions (3' UTRs), respectively (Table S1). Because it is ... See full document
7
Quantifying Gene Expression
... housekeeping gene is performed under the same conditions for all ...housekeeping gene for relative quantitation is ensuring that its expression is truly conserved for all of the sample types being ... See full document
9
Quantifying the specificity of near-duplicate image classification functions
... measuring specificity we make the simplifying assumption that, at least for the smallest few nearest neighbours measured from the set, these distances are the smallest from the whole set of potential distances; ... See full document
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