[PDF] Top 20 Regulation of DNA replication by the S-phase DNA damage checkpoint
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Regulation of DNA replication by the S-phase DNA damage checkpoint
... the checkpoint as a fork modulator is consist- ent with the known vital functions of S-phase checkpoints in stabilizing stalled replication ...of replication in the pres- ence of ... See full document
10
Regulation of DNA Replication Machinery by Mrc1 in Fission Yeast
... a DNA damage check- point kinase: Orc1 is required solely for replication initiation, while Cdc45 is required for both initiation and ...between replication initiation and elongation and the ... See full document
11
RBX1/ROC1-SCF E3 ubiquitin ligase is required for mouse embryogenesis and cancer cell survival
... triggers DNA damage response at the early stage, as demonstrated by induced phosphoralytion of H2AX, Chk1 and Chk2 [17] (and unpublished data), which eventually leads to G2-M arrest, followed by apoptosis ... See full document
6
A conserved Polϵ binding module in Ctf18 RFC is required for S phase checkpoint activation downstream of Mec1
... the S-phase checkpoint response (2–5), which is activated by an increased exposure of single-strand DNA at replication forks, resulting from the combination of defects in DNA ... See full document
10
DNA-activated protein kinase functions in a newly observed S phase checkpoint that links histone mRNA abundance with DNA replication
... of DNA-PK (Stiff et al., 2004). To investigate a role for DNA-PK in the regulation of replication stress–induced histone mRNA decay, we determined the effect of LY294002 on this ...blocks ... See full document
14
Regulation and Modulation of Human DNA Polymerase δ Activity and Function
... PDIP46 was re-discovered as SKAR (S6K1 Aly/REF-like target) [136]. SKAR possesses a RRM (RNA Recognition Motif) (Figure 4) with strong homology to the Aly/REF RNA binding proteins. The latter are involved in coupling ... See full document
30
Mcl1p Is a Polymerase α Replication Accessory Factor Important for S-Phase DNA Damage Survival
... viral replication initiator protein, T antigen, which acts as a dodecameric replicative helicase for viral rep- lication ...of replication fork complexes with ...for DNA un- winding and chromatin ... See full document
12
<p>CDKN3 promotes tumor progression and confers cisplatin resistance via RAD51 in esophageal cancer</p>
... transformation, DNA replication and DNA damage repair (DDR), et al Therefore, we hypothesized that CDKN3 promotes tumor progression through cell cycle regulation and contributes to ... See full document
12
Overlapping Roles of the Spindle Assembly and DNA Damage Checkpoints in the Cell-Cycle Response to Altered Chromosomes in Saccharomyces cerevisiae
... spindle checkpoint blocks anaphase until all chromosomes have achieved success- ful bipolar attachment to the mitotic ...The DNA damage and DNA replication checkpoints block anaphase in ... See full document
14
SIRT1 Deacetylates TopBP1 and Modulates Intra-S-Phase Checkpoint and DNA Replication Origin Firing
... in replication fork protection and origin ...increased replication origin firing, asym- metric fork progression, defective intra-S-phase checkpoint, and chromosome ...in DNA ... See full document
10
Role and Regulation of CIEBPa in Response to DNA Damage
... lysates were prepared at various time points and immunoblot analysis conducted. (C,D) Wild type (open column) and C/EBPα -/- (black column) fibroblasts were synchronized by serum deprivation for 28 h in 0.5% serum and ... See full document
155
The Saccharomyces cerevisiae F-Box Protein Dia2 Is a Mediator of S-Phase Checkpoint Recovery from DNA Damage
... Mrc1 checkpoint function, we did not de- lete the region between residues 431 and 460 because that region was reported to be important for Rad53 checkpoint activation (Naylor et ...any checkpoint ... See full document
19
Working hard for recovery: mitotic kinases in the DNA damage checkpoint
... to DNA repair, Ira el ...induced checkpoint activation ...Cdk1-mediated DNA end resection that is required for ATR activation [51], and direct phosphoryl- ation of Chk1 that is required for efficient ... See full document
8
RAD9, RAD17, and RAD24 Are Required for S Phase Regulation in Saccharomyces cerevisiae in Response to DNA Damage
... To determine whether the slowing of S phase in these mutants was checkpoint-dependent, we constructed all possible double mutant combinations between mecl-1, rad53, rad9A,[r] ... See full document
18
Activation of mammalian Chk1 during DNA replication arrest: a role for Chk1 in the intra-S phase checkpoint monitoring replication origin firing
... the replication timing program controlling origin firing in mammalian cells is reg- ulated by an ATM-independent, caffeine-sensitive check- point activated by replication blocks (Dimitrova and Gil- bert, ... See full document
11
Spy1 Regulation of the DNA Damage Response; Checkpoint Activation and Cellular Senescence
... The DNA damage-signaling pathway is a coordinated phosphorylation-based signaling network that has evolved to maintain genomic integrity in normal cells and reduce cancer cell ...of checkpoint ... See full document
213
Fanconi Anemia FANCM/FNCM-1 and FANCD2/FCD-2 Are Required for Maintaining Histone Methylation Levels and Interact with the Histone Demethylase LSD1/SPR-5 in Caenorhabditis elegans
... epigenetic regulation of fertility given that, in its absence, there is evidence of a progressive accumulation of H3K4me2 and increased sterility through ...the regulation of DNA damage repair ... See full document
15
Regulation of Septum Formation in Aspergillus nidulans by a DNA Damage Checkpoint Pathway
... Figure 8.—A branched regulatory pathway controls the cell types ( Fiddy and Trinci 1976; Harris 1997; timing of septum formation in predivisional hyphal cells. Dis- Kaminskyj and Hamer 1[r] ... See full document
13
The Activation of ATR in Response to Double-Stranded DNA Breaks
... damaged DNA by activating an interconnected web of signaling pathways that mediate the activities of proteins, which detect, repair, and restore DNA ...double-stranded DNA breaks (DSBs), these ... See full document
101
Dissecting The Functions Of Atr In Replication Fork Stability
... tumorigenesis. Using retroviral transduction, Aurora A was overexpressed, but over a period of 2-3 days, cells slowly downregulated Aurora A expression, and within a week, reestablished endogenous levels (data not ... See full document
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