[PDF] Top 20 Replicative function and neutralization sensitivity of envelope glycoproteins from primary and T-cell line-passaged human immunodeficiency virus type 1 isolates.
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Replicative function and neutralization sensitivity of envelope glycoproteins from primary and T-cell line-passaged human immunodeficiency virus type 1 isolates.
... in replicative ability, all of the primary virus envelope glycoproteins demonstrated less sensitivity to neutralizing antibodies directed against the CD4-binding site or the V3 ... See full document
10
Neutralization Synergy of Human Immunodeficiency Virus Type 1 Primary Isolates by Cocktails of Broadly Neutralizing Antibodies
... with T-cell-line-adapted strains of HIV-1, such as the HxB2 molecular clone of HIV-1 used above (37, 44, ...to primary isolates of HIV-1, we analyzed antibody ... See full document
11
Regional Clustering of Shared Neutralization Determinants on Primary Isolates of Clade C Human Immunodeficiency Virus Type 1 from South Africa
... of human immunodeficiency virus type 1 (HIV-1) in the world today and one of the least studied with respect to neutralizing ...to neutralization is derived from ... See full document
12
Quantitative model of antibody- and soluble CD4-mediated neutralization of primary isolates and T-cell line-adapted strains of human immunodeficiency virus type 1.
... of human immunodeficiency virus type 1 (HIV-1) used in neutralization experiments had been adapted in the laboratory to growth in immortalized T-cell lines ... See full document
10
Stoichiometry of Monoclonal Antibody Neutralization of T-Cell Line-Adapted Human Immunodeficiency Virus Type 1
... (19). Virus was generated by env transcomplementation by cotransfection of equal amounts of pSV-A308 and pSV-A308T321, pSV-A308T321, and pSV- A308K373 and by transfection of pSV-A308K373 ...lope-complemented ... See full document
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Neutralization Sensitivity of Human Immunodeficiency Virus Type 1 Primary Isolates to Antibodies and CD4-Based Reagents Is Independent of Coreceptor Usage
... switch from an M- tropic (NSI) to a T-tropic (SI) strain ...on T-tropic viruses and that the V3 loop plays a greater role in the inter- actions of HIV-1 with CXCR4 than with CCR5 (12, ... See full document
10
Coreceptor Utilization by Human Immunodeficiency Virus Type 1 Is Not a Primary Determinant of Neutralization Sensitivity
... and cell tropism are differences in sensitivity to virus ...laboratory-adapted isolates of HIV can be potently neutralized by sera elicited by recombinant gp120 (rgp120) protein, ... See full document
5
Neutralization Profiles of Primary Human Immunodeficiency Virus Type 1 Isolates in the Context of Coreceptor Usage
... of human immunodeficiency virus type 1 (HIV-1) which have only been carried in vitro in peripheral blood mononuclear cells (primary isolates) can be neutralized by ... See full document
9
Primary isolates of human immunodeficiency virus type 1 are relatively resistant to neutralization by monoclonal antibodies to gp120, and their neutralization is not predicted by studies with monomeric gp120.
... site from monomeric gp120 is clearly not the major mechanism underlying the relative resistance of primary virus to most neutralizing ...gp120 from a primary virus does not ... See full document
9
Differential regulation of cellular tropism and sensitivity to soluble CD4 neutralization by the envelope gp120 of human immunodeficiency virus type 1.
... DISCUSSION Using a set of recombinant and mutant viruses generated between two molecularly cloned HIV-1 isolates, HIV-1sF2 a T-cell-line-tropic virus and HIV-1sF162 a macrophage-tropic v[r] ... See full document
7
Neutralization sensitivity of cell culture-passaged simian immunodeficiency virus.
... activity from these cell lines were low but were greatly stimulated upon trans- fection of tat expression ...these cell lines with simian immunodeficiency virus (SIV) or human ... See full document
8
Antibody Binding and Neutralization of Primary and T-Cell Line-Adapted Isolates of Human Immunodeficiency Virus Type 1
... to neutralization by gp120 vaccine sera that neutralize TCLA viruses (cited in reference, 9), several alternative explanations have been proposed, but none has been entirely ...TCLA virus in the absence of ... See full document
12
Cross-clade neutralization of primary isolates of human immunodeficiency virus type 1 by human monoclonal antibodies and tetrameric CD4-IgG.
... are neutralization serotypes, and here again there does not appear to be a consistent cor- relation between HIV-1 neutralization patterns and the ge- netic clades (42, 57, ...general, primary ... See full document
9
An Envelope Modification That Renders a Primary, Neutralization-Resistant Clade B Human Immunodeficiency Virus Type 1 Isolate Highly Susceptible to Neutralization by Sera from Other Clades
... the virus susceptibility to neutralization by polyclonal sera collected from patients in- fected with clade B viruses (Table ...to neutralization by sera collected from pa- tients ... See full document
6
Relative Replicative Fitness of Zidovudine-Resistant Human Immunodeficiency Virus Type 1 Isolates In Vitro
... treat human immunodeficiency virus type 1 (HIV-1) infection appear to result in the selection of drug-resistant mutants, which ultimately limits the benefits of such therapy (for ... See full document
6
Cryptic nature of envelope V3 region epitopes protects primary monocytotropic human immunodeficiency virus type 1 from antibody neutralization.
... The parental MT-CSF infected only PM-1 cells and was markedly resistant to neutralization by sera from HIV-1-infected individuals, rabbit antiserum to recombinant MT-CSF gpl20, and anti-[r] ... See full document
8
Induction of Neutralizing Antibodies to T-Cell Line-Adapted and Primary Human Immunodeficiency Virus Type 1 Isolates with a Prime-Boost Vaccine Regimen in Chimpanzees
... heterologous primary isolates is a first critical step in dispelling the concept that NAbs for primary isolates of HIV-1 cannot be induced by ...antiserum from ... See full document
8
Enfuvirtide Resistance Mutations: Impact on Human Immunodeficiency Virus Envelope Function, Entry Inhibitor Sensitivity, and Virus Neutralization
... resulting from HR1 mutations was that HIV became more sensitive to neutralization by some broadly cross-reactive MAbs as well as antibodies in the sera of some HIV-infected ...to function in the face ... See full document
9
Antibody-Mediated Neutralization of Primary Human Immunodeficiency Virus Type 1 Isolates: Investigation of the Mechanism of Inhibition
... HIV-1 neutralization have been determined from studies of immune sera obtained from naturally infected people or after the spe- cific immunization of humans and animals (7, ...relevant ... See full document
11
Human immunodeficiency virus type 1 envelope glycoproteins gp120 and gp160 induce interleukin-6 production in CD4+ T-cell clones.
... Since the immunoregulatory cytokine interleukin-6 IL-6 plays a major role in inducing B-cell differentiation, we examined the effects of native human immunodeficiency virus type 1 envelo[r] ... See full document
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