[PDF] Top 20 Repression of gene expression upon infection of cells with herpes simplex virus type 1 mutants impaired for immediate-early protein synthesis.
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Repression of gene expression upon infection of cells with herpes simplex virus type 1 mutants impaired for immediate-early protein synthesis.
... viral gene ex- pression has relied on the use of the HSV-1 mutant in1814 and its derivatives in1820 and in1820K (2, 24, ...When cells are infected with in1814, at low multiplicity of infection ... See full document
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Long-Term Transgene Expression in Mice Infected with a Herpes Simplex Virus Type 1 Mutant Severely Impaired for Immediate-Early Gene Expression
... many cells express LATs (50, 63, 64). Upon withdrawal of NGF or upon activation of signal trans- duction pathways in the presence of NGF, reactivation occurs and virus replication rapidly ... See full document
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Repression of the alpha0 gene by ICP4 during a productive herpes simplex virus infection.
... productive infection by herpes simplex virus type 1 (HSV-1), ICP4, the major regulatory protein encoded by the a 4 gene, binds to its transcription ... See full document
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Differential Role of Sp100 Isoforms in Interferon-Mediated Repression of Herpes Simplex Virus Type 1 Immediate-Early Protein Expression
... associated protein aggregates ...IE gene expression (20, 38), in part by counteracting an IFN-induced block to virus tran- scription ...of infection, the virus accumulates ... See full document
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Transactivation of Herpes Simplex Virus Type 1 Immediate-Early Gene Expression by Virion-Associated Factors Is Blocked by an Inhibitor of Cyclin-Dependent Protein Kinases
... productive infection by human herpes simplex virus type 1 (HSV-1) requires cell cycle- dependent protein kinase (cdk) ...of cells with inhibitors of cdks ... See full document
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Binding of ICP4, TATA-Binding Protein, and RNA Polymerase II to Herpes Simplex Virus Type 1 Immediate-Early, Early, and Late Promoters in Virus-Infected Cells
... the protein contributing to its regulatory ...missense mutants, it appears that there are two general phenotypes of ICP4 mutants (8, 13–15, 42, ...the gene, inactivate the DNA-binding proper- ... See full document
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Control of VP16 Translation by the Herpes Simplex Virus Type 1 Immediate-Early Protein ICP27
... in cells infected with viruses lacking ...VP16 gene expres- sion, we undertook a series of experiments that carefully com- pared the levels of VP16 protein and mRNA in cells infected with HSV ... See full document
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Role of Herpes Simplex Virus 1 Immediate Early Protein ICP22 in Viral Nuclear Egress
... IE protein, ICP22, a 420-residue protein encoded by the Us1 gene, conserved in the subfamily Alphaherpesvirinae of the family Her- ...cell type-dependent manner ...Vero cells) and ... See full document
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Reactivation of Expression from Quiescent Herpes Simplex Virus Type 1 Genomes in the Absence of Immediate-Early Protein ICP0
... -Gal expression or in1374 replication was approx- imately 10-fold lower during superinfection than during coin- fection, when the response to dl1403Y was compared with the response to ...super- infection ... See full document
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The Ability of Herpes Simplex Virus Type 1 Immediate-Early Protein Vmw110 To Bind to a Ubiquitin-Specific Protease Contributes to Its Roles in the Activation of Gene Expression and Stimulation of Virus Replication
... activate gene expression in transfected ...on virus replication, single-step growth curve experiments were conducted with BHK cells and all the available virus mutants and the ... See full document
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Cellular SNF2H Chromatin Remodeling Factor Promotes Herpes Simplex Virus 1 Immediate Early Gene Expression and Replication
... nucleus, herpes simplex virus 1 (HSV-1) regulates the association of his- tones with its genome to promote viral replication and gene ...infected cells, suggesting that ... See full document
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Neurons differentially control expression of a herpes simplex virus type 1 immediate-early promoter in transgenic mice.
... viral infection and disease (29). It has also been shown that infection with HSV type 1 (HSV-1) induces expression of the Oct 1 gene in sensory neurons ...host ... See full document
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Activation of gene expression by herpes simplex virus type 1 ICP0 occurs at the level of mRNA synthesis.
... null mutants is highly multiplicity de- pendent (7, 8, 18, ...tion, gene expression and replication are severely impaired in ICP0 null mutant-infected cells relative to wild-type ... See full document
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Herpes Simplex Virus Type 1 Immediate-Early Protein ICP22 Is Required for VICE Domain Formation during Productive Viral Infection
... HeLa cells were mock infected or infected with WT HSV-1, TF22, or the various FLAG-tagged ...infected cells ex- pressed the expected forms of ICP22 (1) ...HSV-1 infection does ... See full document
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Herpes simplex virus type 1 ICP0 regulates expression of immediate-early, early, and late genes in productively infected cells.
... To examine the role of ICPO in the regulation of viral gene expression during productive infection, we characterized the wild-type virus, an ICPO null mutant 7134, and several ICPO nonse[r] ... See full document
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Differential dependence of herpes simplex virus immediate-early gene expression on de novo-infected cell protein synthesis.
... Addition of the protein synthesis inhibitor anisomycin to cells coincident with infection resulted in maximal rates of transcription and accumulation of functional ICPO mRNA, while 0.5 h[r] ... See full document
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Temperature-sensitive mutants in herpes simplex virus type 1 ICP4 permissive for early gene expression.
... Fifteen to fifty percent of wild-type levels of viral DNA are synthesized at the nonpermissive temperature in ts48- and ts303-infected cells, indicating that immediate-early and early ge[r] ... See full document
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Identification of dominant-negative mutants of the herpes simplex virus type 1 immediate-early protein ICP0.
... Regulation of the herpes simplex virus type 1 late gamma2 glycoprotein C gene: sequences between base pairs -34 to +29 control transient expression and responsiveness to transactivation [r] ... See full document
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Isolation and characterization of deletion mutants of herpes simplex virus type 1 in the gene encoding immediate-early regulatory protein ICP4.
... To determine more specifically whether the rates of synthesis of ICPO, ICP27, and ICP6 in d120- and d202-infected cells differ from that in tsB32-infected cells and to examine the possib[r] ... See full document
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Transcriptional Coactivators Are Not Required for Herpes Simplex Virus Type 1 Immediate-Early Gene Expression In Vitro
... IE gene ex- pression, we repeated the low-MOI experiments in the pres- ...IE gene expression is not impaired in SiHa cells but is augmented in the presence of wild-type ...SiHa ... See full document
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