[PDF] Top 20 Role of Matrix in an Early Postentry Step in the Human Immunodeficiency Virus Type 1 Life Cycle
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Role of Matrix in an Early Postentry Step in the Human Immunodeficiency Virus Type 1 Life Cycle
... resulting virus was harvested, normal- ized for RT activity, and used to infect the CEM(12D-7) T-cell ...pNL4-3KFS-derived virus was used as a negative ...an early step in the virus ... See full document
11
Human Immunodeficiency Virus Type 1 Matrix Protein Interacts with Cellular Protein HO3
... a role during the early steps of the infectious process by promoting the nuclear migration of the uncoated viral nucleoprotein complex, also known as the preintegration complex, and thereby facilitating ... See full document
6
Targeting human immunodeficiency virus type 1 reverse transcriptase by intracellular expression of single-chain variable fragments to inhibit early stages of the viral life cycle.
... adding 1 m l of ...leukemia virus-based retroviruses were produced by transfection of recombinant retroviral vector plasmids into PA317 packaging ...for 1 more week in medium containing ... See full document
13
Phosphorylation of Human Immunodeficiency Virus Type 1 Vpr Regulates Cell Cycle Arrest
... Human immunodeficiency virus 1 (HIV-1) primarily targets CD4 T cells and macrophages (10, ...important role in the early stages of HIV-1 infection in terminally ... See full document
8
Antiviral activity of human immunodeficiency virus type 1 protease inhibitors in a single cycle of infection: evidence for a role of protease in the early phase.
... 757-765 0022-538X/94/$04.00 + 0 Copyright © 1994, American Society for Microbiology Antiviral Activity of Human Immunodeficiency Virus Type 1 Protease Inhibitors in a Single Cycle of Inf[r] ... See full document
9
Postentry Restriction to Human Immunodeficiency Virus-Based Vector Transduction in Human Monocytes
... and matrix (6). A subset of phosphorylated matrix proteins has also been described as having a role in nuclear entry (14, ...the virus, the central polypurine tract (cPPT), has been proposed ... See full document
9
Cyclophilin A Plays Distinct Roles in Human Immunodeficiency Virus Type 1 Entry and Postentry Events, as Revealed by Spinoculation
... HIV-1 life cycle have been attrib- uted to ...between virus-associated CypA and cell surface CD147 ...simian immunodeficiency virus ... See full document
7
Human immunodeficiency virus type 1 Vpr induces apoptosis following cell cycle arrest.
... 64). This CD4 T-cell death is hypothesized to eventually ex- haust the immune system’s regenerative properties and lead to CD4 cell depletion and, eventually, AIDS. We have observed that Vpr is capable of arresting cells ... See full document
14
Role of Vif in human immunodeficiency virus type 1 reverse transcription.
... of human immunodeficiency virus type 1 (HIV-1) is important for virion ...the role of Vif in viral DNA synthesis in the endogenous reverse transcriptase (RT) reaction, an ... See full document
9
Role of Vif in Stability of the Human Immunodeficiency Virus Type 1 Core
... of early postentry ...anemia virus lacks a Vif protein (41) and has an unusually stable core (6, ...disassembly. Early postentry events and viral DNA synthesis can occur in the absence ... See full document
12
Role of the karyopherin pathway in human immunodeficiency virus type 1 nuclear import.
... the human immunodeficiency virus type 1 (HIV-1) nucleoprotein complex with the cell nuclear import machinery is necessary for viral replication in macrophages and for the ... See full document
6
A Strongly Transdominant Mutation in the Human Immunodeficiency Virus Type 1 gag Gene Defines an Achilles Heel in the Virus Life Cycle
... structural role, as it anchors a salt bridge between its ring nitrogen and carboxylate group of a conserved aspartic acid (D51 in HIV-1 CA), creating a new loop with the N-terminal protein sequence that ... See full document
8
The Nef protein of human immunodeficiency virus type 1 enhances serine phosphorylation of the viral matrix.
... Matrix (MA) is the N-terminally myristoylated cleavage product of the Gag polyprotein precursor by the viral protease (12). An essential structural element of retroviruses, MA gov- erns HIV-1 assembly by ... See full document
6
Role of Human Immunodeficiency Virus Type 1 Integrase in Uncoating of the Viral Core
... viral life cycle (10, 14, 17, 28, 44, 62, 64, 69), but to our knowledge, a requirement for IN during uncoating has not been previously ...its role in uncoat- ing, HIV-1 IN physically interacts ... See full document
10
Intracellular expression of single-chain variable fragments to inhibit early stages of the viral life cycle by targeting human immunodeficiency virus type 1 integrase.
... the virus-encoded enzyme integrase (IN). As IN plays a pivotal role in establishing infection during the early stages of the retroviral life cycle, it is an attractive target for ... See full document
16
Conditional human immunodeficiency virus type 1 protease mutants show no role for the viral protease early in virus replication.
... Table 1, neither the wild-type virus nor the V32I/V82I mutant showed any decrease in infectivity when the infection was done in the presence of the PR inhibitor at concentrations between ...of ... See full document
5
Human immunodeficiency virus type 1 coreceptors participate in postentry stages in the virus replication cycle and function in simian immunodeficiency virus infection.
... initiate virus infection. Simian immunodeficiency virus (SIV) productively infects human cells expressing CD4 and the human allele of the chemokine coreceptor CCR-5 as efficiently as it ... See full document
8
Role of the basic domain of human immunodeficiency virus type 1 matrix in macrophage infection.
... the role of the highly basic region of HIV-1 MA in the virus life cycle, particularly with respect to macrophage infection, we introduced a series of single- and ... See full document
6
Analysis of Human Immunodeficiency Virus Type 1 Matrix Binding to Membranes and Nucleic Acids
... The matrix (MA) domain of the human immunodeficiency virus type 1 (HIV-1) precursor Gag (PrGag) protein serves several functions in the viral replication ...encapsidation ... See full document
8
The role of Gag in human immunodeficiency virus type 1 virion morphogenesis and early steps of the viral life cycle.
... To assess the possibility of size or shape variation of the virion particles, nonequilibrium velocity gradients were per- formed. Purified virions were layered over 5 to 20% sucrose gradients and centrifuged for 90 min. ... See full document
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