[PDF] Top 20 Sensitive Phenotypic Detection of Minor Drug Resistant Human Immunodeficiency Virus Type 1 Reverse Transcriptase Variants
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Sensitive Phenotypic Detection of Minor Drug Resistant Human Immunodeficiency Virus Type 1 Reverse Transcriptase Variants
... and reverse transcription ...select reverse transcription events. Elements carrying wild-type RT (H2BX) and the NNRTI resistance allele K103N were placed on each plate as ... See full document
9
Augmentation of Human Immunodeficiency Virus Type 1 Subtype E (CRF01_AE) Multiple-Drug Resistance by Insertion of a Foreign 11-Amino-Acid Fragment into the Reverse Transcriptase
... 93JP-NH1 virus isolate, a drug-sensitive NH virus predecessor ...parental virus in MAGIC-5 cells (right panel, ERT-mt1 to ...replication-competent variants in combination with ... See full document
10
Selective Excision of AZTMP by Drug-Resistant Human Immunodeficiency Virus Reverse Transcriptase
... RT resistant to the nucleoside analog dideoxyinosine (ddI) ...RT variants were as sensitive to AZTTP ...(Fig. 1), the RT mutants T215Y and AZT-21 were not able to polymerize as efficiently as ... See full document
11
Effects of Human Immunodeficiency Virus Type 1 Resistance to Protease Inhibitors on Reverse Transcriptase Processing, Activity, and Drug Sensitivity
... Human immunodeficiency virus type 1 (HIV-1) variants resistant to protease inhibitors often display a reduced replicative capacity as a result of an impairment of ... See full document
5
Human Immunodeficiency Virus Mutagenesis during Antiviral Therapy: Impact of Drug-Resistant Reverse Transcriptase and Nucleoside and Nonnucleoside Reverse Transcriptase Inhibitors on Human Immunodeficiency Virus Type 1 Mutation Frequencies
... Several drug-resistant RT variants were observed to signifi- cantly alter HIV-1 mutation ...in virus mutation frequen- cies, which is in contrast to the individual mutations, which do ... See full document
13
Influence of Reverse Transcriptase Variants, Drugs, and Vpr on Human Immunodeficiency Virus Type 1 Mutant Frequencies
... Vpr variants deficient for binding to ...wt virus in the absence of ...ciency virus (SIV) have indicated that, during the course of disease progression, changes in fidelity occur ...and ... See full document
10
Increased Multinucleoside Drug Resistance and Decreased Replicative Capacity of a Human Immunodeficiency Virus Type 1 Variant with an 8-Amino-Acid Insert in the Reverse Transcriptase
... Phenotypic drug resistance ...the drug resistance pheno- type (Fig. 1); one pretherapy sample (3 May 1994), one sample taken during ZDV monotherapy (21 March 1995), and two samples ... See full document
8
Decreased Processivity of Human Immunodeficiency Virus Type 1 Reverse Transcriptase (RT) Containing Didanosine-Selected Mutation Leu74Val: a Comparative Analysis of RT Variants Leu74Val and Lamivudine-Selected Met184Val
... the virus and a significant loss in fitness com- pared to the wild-type virus in a drug-free medium ...The detection of mutation Leu74Val in clinical isolates during clin- ical trials ... See full document
9
Amino Acid Mutation N348I in the Connection Subdomain of Human Immunodeficiency Virus Type 1 Reverse Transcriptase Confers Multiclass Resistance to Nucleoside and Nonnucleoside Reverse Transcriptase Inhibitors
... of human immunodeficiency virus type 1 (HIV-1) infections in highly active antiretroviral therapies (HAART) can dramati- cally reduce viral load, increase levels of CD4positive ... See full document
10
Individual Contributions of Mutant Protease and Reverse Transcriptase to Viral Infectivity, Replication, and Protein Maturation of Antiretroviral Drug-Resistant Human Immunodeficiency Virus Type 1
... Human immunodeficiency virus type 1 (HIV-1) variants resistant to protease (PR) and reverse transcriptase (RT) inhibitors may display impaired ... See full document
10
(Alkylamino) piperidine bis(heteroaryl)piperizine analogs are potent, broad-spectrum nonnucleoside reverse transcriptase inhibitors of drug-resistant isolates of human immunodeficiency virus type 1 (HIV-1) and select for drug-resistant variants of HIV-1IIIB with reduced replication phenotypes.
... m l of supernatant with Tri Reagent LS (Molecular Research Center, Inc.), extracting with chloroform, and precipitating with isopropanol. Glycogen served as the carrier during the precipitation. The pelleted RNA was ... See full document
8
Human Immunodeficiency Virus Type 1 Subtype F Reverse Transcriptase Sequence and Drug Susceptibility
... the phenotypic susceptibility analysis showed that diversity within group M might affect drug ...naturally resistant variants. HIV-1 group O isolates are naturally resistant to ... See full document
5
MultiCode RTx Real Time PCR System for Detection of Subpopulations of K65R Human Immunodeficiency Virus Type 1 Reverse Transcriptase Mutant Viruses in Clinical Samples
... Recently a real-time PCR technology called MultiCode- RTx (EraGen Biosciences) was reported that quantitated M184V and K65R HIV-1 RT mutants down to a level of 0.01% in plasmid DNA mixtures (13). However, likely ... See full document
5
Analysis of nonnucleoside drug-resistant variants of human immunodeficiency virus type 1 reverse transcriptase.
... not, by themselves, appear to be important in determining the sensitivity of HIV-1 RT to TBA, HEPT, or calanolide A, it is still possible that these substitutions could have an effect if[r] ... See full document
9
Genetic Diversity of Protease and Reverse Transcriptase Sequences in Non Subtype B Human Immunodeficiency Virus Type 1 Strains: Evidence of Many Minor Drug Resistance Mutations in Treatment Naive Patients
... Human immunodeficiency virus (HIV) replication is mark- edly inhibited by highly active antiretroviral drug combina- ...analogue reverse transcriptase (RT) inhibitors (NRTIs), ... See full document
7
Comparative Analysis of Two Commercial Phenotypic Assays for Drug Susceptibility Testing of Human Immunodeficiency Virus Type 1
... Human immunodeficiency virus type 1 (HIV-1) isolates from 50 plasma specimens were analyzed for phenotypic susceptibility to licensed reverse transcriptase ... See full document
5
Template Usage Is Responsible for the Preferential Acquisition of the K65R Reverse Transcriptase Mutation in Subtype C Variants of Human Immunodeficiency Virus Type 1
... of human immunodeficiency virus type 1 ...to drug resistance mutations and responsiveness to therapy may be premature (2, 6, 9, 12, 13, ... See full document
5
Human recombinant antibody fragments neutralizing human immunodeficiency virus type 1 reverse transcriptase provide an experimental basis for the structural classification of the DNA polymerase family.
... each virus per cell) and harvested 72 h ...KCl, 1 mM EDTA, 1 mM dithiothreitol, protease inhibitor cocktail), homogenized with a Dounce homogenizer (30 strokes, 4 8 C), and centrifuged for 30 min at ... See full document
7
Genotypic, Phenotypic, and Modeling Studies of a Deletion in the β3-β4 Region of the Human Immunodeficiency Virus Type 1 Reverse Transcriptase Gene That Is Associated with Resistance to Nucleoside Reverse Transcriptase Inhibitors
... of human immunodeficiency virus type 1 (HIV-1) reverse tran- scriptase (RT) are associated with resistance to nucleoside analog ...6.2 drug resistance-associated ... See full document
7
Effect of the Human Immunodeficiency Virus Type 1 Reverse Transcriptase Polymorphism Leu-214 on Replication Capacity and Drug Susceptibility
... Structural analysis. The structural analysis was performed by using the X-ray crystallographic coordinates of HIV-1 RT deposited in the Protein Data Bank (http://www.rcsb.org/PDB) with code 1N6Q (27). This ... See full document
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