[PDF] Top 20 Simian Virus 40 Large T Antigen Can Specifically Unwind the Central Palindrome at the Origin of DNA Replication
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Simian Virus 40 Large T Antigen Can Specifically Unwind the Central Palindrome at the Origin of DNA Replication
... of simian virus 40 (SV40) large T antigen play a critical role in DNA ...normal DNA binding and ATPase and helicase activities but with a severely reduced ability ... See full document
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The N-terminal side of the origin-binding domain of simian virus 40 large T antigen is involved in A/T untwisting.
... Simian virus 40 (SV40) T antigen is a multifunctional pro- tein and the only viral protein involved in SV40 DNA replica- ...initiate DNA replication, T ... See full document
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Role of Single-Stranded DNA Binding Activity of T Antigen in Simian Virus 40 DNA Replication
... single-stranded DNA binding domain of large T antigen to amino acid residues 259 to ...support simian virus 40 (SV40) replication and to bind to single-stranded ... See full document
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Replication of simian virus 40 origin-containing DNA during infection with a recombinant Autographa californica multiple nuclear polyhedrosis virus expressing large T antigen.
... of DNA replication through the origin and large T-antigen initiator protein of ...heterologous DNA is all the more surprising when the speci- ficity of baculovirus origins ... See full document
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Mechanisms of interference with simian virus 40 (SV40) DNA replication by trans-dominant mutants of SV40 large T antigen.
... By cotransfecting CV-1 cells with an origin-defective plasmid encoding wild-type T antigen and a replicationcompetent plasmid encoding mutant T antigen, we saw that the level of interfer[r] ... See full document
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Mutational Analysis of Simian Virus 40 T-Antigen Primosome Activities in Viral DNA Replication
... papovavirus simian virus 40 (SV40) minichromosome has been used extensively as a model to study the mechanism of eukaryotic DNA replication (see references 8 and 24 and references ... See full document
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Replication Stress and Mitotic Dysfunction in Cells Expressing Simian Virus 40 Large T Antigen
... reduces DNA damage markers, anaphase bridges, and micronuclei, consistent with a replica- tion stress ...response. Replication stress may result from aberrant origin firing or replication fork ... See full document
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Role of the Hydrophilic Channels of Simian Virus 40 T-Antigen Helicase in DNA Replication
... WT T antigen, especially at low protein ...the central channel, whereas T536 and R540 are on the adjacent subunit about halfway out of the hydro- philic channel and fairly close to the back surface ... See full document
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The finger domain of simian virus 40 large T antigen controls DNA-binding specificity.
... Mutations in the phosphorylation sites of simian virus 40 SV40 T antigen alter its origin DNA-binding specificity for sites I and II and affect SV40 DNA replication activity.. Initiation[r] ... See full document
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Interaction of the Transcription Factor TFIID with Simian Virus 40 (SV40) Large T Antigen Interferes with Replication of SV40 DNA In Vitro
... of replication by transcription factors is com- mon among the papovaviruses and adenoviruses (reviewed in references 20 and 21) but is not limited to viral ...activate replication from chromosomal origins ... See full document
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Characterization of the DNA-Binding Properties of the Origin-Binding Domain of Simian Virus 40 Large T Antigen by Fluorescence Anisotropy
... Small DNA tumor viruses such as simian virus 40 (SV40), polyomavirus, or papillomavirus have become important model systems for the study of molecular events involved in DNA ...protein, ... See full document
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Mutation of the cyclin-dependent kinase phosphorylation site in simian virus 40 (SV40) large T antigen specifically blocks SV40 origin DNA unwinding.
... A mutant T antigen carrying alanine in place of Thr-124 T124A also failed to replicate SV40 DNA in vitro and was defective in its ability to initiate replication in vitro Knowledge of eu[r] ... See full document
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Topoisomerase I Associates Specifically with Simian Virus 40 Large-T-Antigen Double Hexamer–Origin Complexes
... nick origin DNA dur- ing a DNA-unwinding ...we can esti- mate that there are relatively few topo I molecules bound because the presence of the enzyme had no detectable effect on the mobility ... See full document
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Quantitative Analysis of the Binding of Simian Virus 40 Large T Antigen to DNA
... Eukaryotic DNA replication is a complex process that is initiated by the coordinated action of several factors, including the origin recognition complex, cdt1, cdc6, and the minichro- mosome ... See full document
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Crystal Structure of the Simian Virus 40 Large T-Antigen Origin-Binding Domain
... the central channel of the ring without disrupting the hexamer or cutting the nucleic acid ...sixfold T-ag obd structure observed in our crystals was ...the T-ag obd double hexamer with DNA. ... See full document
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Large T-antigen mutants define multiple steps in the initiation of simian virus 40 DNA replication.
... In the presence of RF-A, a eucaryotic single-stranded DNA-binding protein required for origin-specific unwinding and the initiation of DNA replication 23, 81, and a topoisomerase which r[r] ... See full document
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The T-antigen-binding domain of the simian virus 40 core origin of replication.
... The lesser role of these intervening sequences is probably related to T-antigen binding rather than to cruciform formation because the central base pair at position 5243 would have no ef[r] ... See full document
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Simian virus 40 (SV40) small t antigen inhibits SV40 DNA replication in vitro.
... This dramatic inhibition by small t depends on the presence of large T during the preincubation period; when extracts were preincubated with small t alone and large T was added at the be[r] ... See full document
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Binding of simian virus 40 a protein to DNA with deletions at the origin of replication.
... Analysis of A protein binding to a series of nonviable mutanfts progressively deleting these contact sites leads to the following conclusions: i stable binding of subunits of A protein t[r] ... See full document
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A deletion in the simian virus 40 large T antigen impairs lytic replication in monkey cells in vivo but enhances DNA replication in vitro: new complementation function of T antigen.
... 2195-2207 0022-538X/92/042195-13$02.00/0 Copyright © 1992, American Society for Microbiology A Deletion in the Simian Virus 40 Large T Antigen Impairs Lytic Replication in Monkey Cells I[r] ... See full document
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