[PDF] Top 20 A Herpes Simplex Virus Type 1 Latency-Associated Transcript Mutant with Increased Virulence and Reduced Spontaneous Reactivation
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A Herpes Simplex Virus Type 1 Latency-Associated Transcript Mutant with Increased Virulence and Reduced Spontaneous Reactivation
... marker-rescued virus dLAT2903R, dLAT371 and its marker-rescued virus dLAT371R, and ...LAT transcript(s) made by each virus are detailed in ...LAT transcript in the wild- type and ... See full document
10
A 437-base-pair deletion at the beginning of the latency-associated transcript promoter significantly reduced adrenergically induced herpes simplex virus type 1 ocular reactivation in latently infected rabbits.
... HSV reactivation have not been satisfactorily explained nor proven by antisense mechanisms or postulated LAT protein ...the reactivation potential of ...induced reactivation potential of ... See full document
5
Herpes Simplex Virus Latency-Associated Transcript Sequence Downstream of the Promoter Influences Type-Specific Reactivation and Viral Neurotropism
... chimeric virus HSV2-LAT-P1 (see Fig. 1), the HSV-1 promoter region from NotI to PvuI sites (118439 to 118802) was cloned from the HSV-1 Avr-Alu ⌬ Xho plasmid into the HSV-2 Sph-Sal-Bam ... See full document
9
Interactions between Herpesvirus Entry Mediator (TNFRSF14) and Latency-Associated Transcript during Herpes Simplex Virus 1 Latency
... proteins herpes simplex virus (HSV) uses for attachment/en- ...Interestingly, latency-associated transcript (LAT), the only viral gene consistently expressed during neuronal ... See full document
11
Herpes Simplex Virus Type 1 Latency-Associated Transcript Gene Promotes Neuronal Survival
... and herpes simplex virus type 1 ...the virus can also enter a latent state in these ...The latency-associated transcript (LAT) regulates the establishment of ... See full document
16
Herpes Simplex Virus Type 1 Latency-Associated Transcript Expression Protects Trigeminal Ganglion Neurons from Apoptosis
... HSV latency is less ...antigen associated with major histocompatibility complex class I, thereby allowing infected cells to evade cell-mediated immu- nity ...ICP47-null mutant exhibited ... See full document
7
An avirulent ICP34.5 deletion mutant of herpes simplex virus type 1 is capable of in vivo spontaneous reactivation.
... on spontaneous reactivation is to analyze the number of times spontaneous reactivation is detected in each eye, regardless of the length of time virus is ...reactivated virus is ... See full document
9
Three Herpes Simplex Virus Type 1 Latency-Associated Transcript Mutants with Distinct and Asymmetric Effects on Virulence in Mice Compared with Rabbits
... reactivated virus. This was significantly less than the results for wild-type McKrae ...for spontaneous reactivation (i.e., the percentage of virus- positive cultures) and plotted the ... See full document
11
Mutations in the 5' end of the herpes simplex virus type 2 latency-associated transcript (LAT) promoter affect LAT expression in vivo but not the rate of spontaneous reactivation of genital herpes.
... which virus could subsequently re- ...2 mutant, higher rather than reduced levels of latent DNA ...2 virus in acutely infected ganglia reflect exper- imental ... See full document
8
A Gene Capable of Blocking Apoptosis Can Substitute for the Herpes Simplex Virus Type 1 Latency-Associated Transcript Gene and Restore Wild-Type Reactivation Levels
... LAT transcript in wild-type virus and marker-rescued dLAT2903R is ...LAT transcript (indicated by “XXXXX”). This virus is missing key promoter elements, makes no LAT RNA, is a true LAT ... See full document
12
Herpes Simplex Virus Type 1 Latency-Associated Transcript Reduces Human Neuroblastoma Cell Proliferation
... LAT virus is able to make extensive apoptosis in rabbit trigeminal ganglia, the virus encoding wild type LAT blocks apoptosis in culture cells ...LAT-null mutant is increased versus ... See full document
8
The 2.2-Kilobase Latency-Associated Transcript of Herpes Simplex Virus Type 2 Does Not Modulate Viral Replication, Reactivation, or Establishment of Latency in Transgenic Mice
... a transcript would fail to function in trans in an antisense capacity, regardless of whether it is derived from the viral or the host ...during latency HSV-1 and HSV-2 LAT regions, despite the ... See full document
7
Spontaneous Reactivation of Herpes Simplex Virus Type 1 in Latently Infected Murine Sensory Ganglia
... with herpes simplex virus type 1 (HSV-1) indicate the presence of productive cycle viral gene products and persistent immune response, suggesting ongoing spontaneous viral ... See full document
6
Tissue-Specific Splicing of the Herpes Simplex Virus Type 1 Latency-Associated Transcript (LAT) Intron in LAT Transgenic Mice
... of latency between the transgenic and nontransgenic mice was ...LAT mutant reac- tivated this mutant more efficiently than nontransgenic ...rescue reactivation defects of LAT mutants in ...or ... See full document
10
The Latency-Associated Transcript Gene Enhances Establishment of Herpes Simplex Virus Type 1 Latency in Rabbits
... This mutant, designated LAT-EGFP-2, was con- structed beginning with ...LAT transcript in the ectopic location between UL37 and UL38, and it has wt spon- taneous reactivation despite lacking LAT in ... See full document
7
A 348-base-pair region in the latency-associated transcript facilitates herpes simplex virus type 1 reactivation.
... LAT transcript and indicate that the reactivation phe- notype resides at the 5 * ...induced reactivation, we sought to identify the genetic element(s) responsible for this ...(Fig. 1). These ... See full document
11
Region of Herpes Simplex Virus Type 1 Latency-Associated Transcript Sufficient for Wild-Type Spontaneous Reactivation Promotes Cell Survival in Tissue Culture
... Approximately 90% of steady-state LAT (i.e., the stable 2-kb LAT) is localized in the nucleus (50, 56). Only 10% of LAT is found in the cytoplasm, some of which appears to be associated with polyribosomes (24). At ... See full document
11
Herpes Simplex Virus Type 1 2-Kilobase Latency-Associated Transcript Intron Associates with Ribosomal Proteins and Splicing Factors
... During latency of herpes simplex virus type 1 in sensory neurons, the transcription of viral genes is restricted to the latency-associated transcripts ...deletion ... See full document
11
A deletion mutant of the latency-associated transcript of herpes simplex virus type 1 reactivates from the latent state with reduced frequency.
... American Society for Microbiology A Deletion Mutant of the Latency-Associated Transcript of Herpes Simplex Virus Type 1 Reactivates from the Latent State with Reduced Frequency Received [r] ... See full document
8
Identification of Herpes Simplex Virus Type 1 Latency-Associated Transcript Sequences That both Inhibit Apoptosis and Enhance the Spontaneous Reactivation Phenotype
... lanes 1 and ...wild-type virus (lanes 5 and ...the reduced LAT antiapoptosis activity seen with pLAT(1-1499)⌬Sty was unlikely to be the result of re- duced levels of LAT RNA compared to ... See full document
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