[PDF] Top 20 Structural Comparison of HIV-1 Envelope Spikes with and without the V1/V2 Loop
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Structural Comparison of HIV-1 Envelope Spikes with and without the V1/V2 Loop
... Env spikes comprising gp120 and the ectodo- main of gp41 have been fraught with issues of stability (re- viewed in references 63 and ...⌬ V1/V2 mutant constructs can be less stable than WT constructs ... See full document
10
The V1, V2, and V3 Regions of the Human Immunodeficiency Virus Type 1 Envelope Differentially Affect the Viral Phenotype in an Isolate-Dependent Manner
... these envelope proteins is ...the V2 loop within the trimeric form of these three envelopes that differentially affect their processing, sta- ...⌬ V1, SF162 ⌬ V2, and SF162 ⌬ V1V2 ...V3 ... See full document
12
HIV 2 interaction with cell coreceptors: amino acids within the V1/V2 region of viral envelope are determinant for CCR8, CCR5 and CXCR4 usage
... mapped HIV-2 enve- lope glycoproteins determinants of CCR8 coreceptor usage, and the amino acids residues involved in coreceptor switch from R8 to R5 or R8 to ...the V1/V2 region contains the ... See full document
17
Structural Constraints at the Trimer Apex Stabilize the HIV 1 Envelope in a Closed, Antibody Protected Conformation
... anti-V2 loop glycan bNAbs, such as PG9 and PG16, but also bNAbs against the V3 loop glycan and the CD4-BS have a strong bias toward the recognition of the closed trimer, in some cases with a nearly ... See full document
15
Structural Characterization of Cleaved, Soluble HIV-1 Envelope Glycoprotein Trimers
... subtle structural effect on the gp120s, this region can be added or removed without affecting the major antigenic sites on gp120, including the CD4 binding site, as well as the N-linked glycans at N332 and ... See full document
8
Distinct Mechanisms Regulate Exposure of Neutralizing Epitopes in the V2 and V3 Loops of HIV-1 Envelope
... neutralize HIV-1 is that the V1V2 and V3 regions are highly dynamic on Env spikes, continually flickering from one conformation to another and rarely adopting the structures rec- ognized by the ... See full document
13
Replication and neutralization of human immunodeficiency virus type 1 lacking the V1 and V2 variable loops of the gp120 envelope glycoprotein.
... the V1 and V2 loops has been shown to increase the exposure of the CD4i epitopes on the monomeric HIV-1 gp120 glycopro- tein ...with V1 and V2 deleted to neutralization by an ... See full document
5
Involvement of the V1/V2 variable loop structure in the exposure of human immunodeficiency virus type 1 gp120 epitopes induced by receptor binding.
... native HIV-1 gp120 ...variable loop deletions on the 17b and 48d epitopes were seen in these two assay ...using envelope glycoproteins in solution confirm that the highly conserved stem in the ... See full document
11
Role of Low CD4 Levels in the Influence of Human Immunodeficiency Virus Type 1 Envelope V1 and V2 Regions on Entry and Spread in Macrophages
... and V1/V2 loop ...of HIV-1 clones, BBB, NBB, and ...certain HIV-1 clones, depend- ing mostly on their V2 envelope sequences; however, V1 also ...3. ... See full document
10
Human Immunodeficiency Virus Type 1 V1-V2 Envelope Loop Sequences Expand and Add Glycosylation Sites over the Course of Infection, and These Modifications Affect Antibody Neutralization Sensitivity
... FIG. 1. Phylogram of envelope sequences from the nine subjects described here, sequences from other subjects previously isolated in our laboratory, and reference subtype sequences from the Los Alamos ... See full document
13
Alterations in the Immunogenic Properties of Soluble Trimeric Human Immunodeficiency Virus Type 1 Envelope Proteins Induced by Deletion or Heterologous Substitutions of the V1 Loop
... the V1 loop or immunization with a mix- ture of gp140 scaffolds expressing heterologous V1 loops) resulted in decreases in V3 ...of structural in- formation on Env that includes the V1 ... See full document
15
Visualization of Retroviral Envelope Spikes in Complex with the V3 Loop Antibody 447-52D on Intact Viruses by Cryo-Electron Tomography
... V3 loop conformation and the basis for neutralization by anti-V3 MAbs, we attempted fitting of rele- vant atomic structures into our density ...with HIV-1 MN V3 peptide has been crystallized (58, 77, ... See full document
11
Potent and Broad Neutralization of HIV-1 Subtype C by Plasma Antibodies Targeting a Quaternary Epitope Including Residues in the V2 Loop
... in V2 that contributed to this epitope, namely, the FN/LRD-K-K motif (ranging from F159 to ...exceeding 1:10,000) by a single mutation in the FN/LRD-K-K ...long V1 loop being much less ... See full document
14
A Trimeric HIV-1 Envelope gp120 Immunogen Induces Potent and Broad Anti-V1V2 Loop Antibodies against HIV-1 in Rabbits and Rhesus Macaques
... Trimeric HIV-1 envelope (Env) immunogens are attractive due to their ability to display quaternary epitopes targeted by broadly neutralizing anti- bodies (bNAbs) while obscuring unfavorable ... See full document
15
Mutation at a Single Position in the V2 Domain of the HIV-1 Envelope Protein Confers Neutralization Sensitivity to a Highly Neutralization-Resistant Virus
... the V2 masking function is dependent on quaternary interactions be- tween the gp160 subunits that associate to form the trimeric envelope structure that mediates virus infectivity and fusion (13, 35, ...on ... See full document
10
Importance of the V1/V2 Loop Region of Simian-Human Immunodeficiency Virus Envelope Glycoprotein gp120 in Determining the Strain Specificity of the Neutralizing Antibody Response
... type 1 (HIV-1) are known to be highly strain specific in their ability to neutralize HIV-1 ...autologous HIV-1 isolates but typically exhibit little or no activity against ... See full document
13
Plasticity and Epitope Exposure of the HIV-1 Envelope Trimer
... of V2 that are required for engagement are not present in the JR-FL sequence ...significant structural displacements induced by disrupting the hydrophobic core of gp120 allowed unusual contacts with the MAb ... See full document
17
Optimization of Human Immunodeficiency Virus Type 1 Envelope Glycoproteins with V1/V2 Deleted, Using Virus Evolution
... with loop deletions. Env variants with variable loop deletions have been generated by us and others for func- tional, structural, and vaccine studies, but most of these con- structs are slightly ... See full document
16
Determinants of Syncytium Formation in Microglia by Human Immunodeficiency Virus Type 1: Role of the V1/V2 Domains
... equivalent envelope expression among the recombinant viruses (data not ...the V1/V2 region, with the bulk of the VH-B15 fuso- genicity accounted for by a single-amino-acid difference, ... See full document
9
Structural Characterizations of the Dimeric Anti-HIV Antibody 2G12 and the HIV-2 Envelope Glycoprotein
... type 1 (HIV-1) lie in structural features of the gp120-gp41 envelope spike trimer: the spike’s variable loops are highly susceptible to rapid mutation (Starcich et ...against ... See full document
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