[PDF] Top 20 Structural and kinetic analyses of herpes simplex virus type 1 latency associated transcripts in human trigeminal ganglia and in cell culture
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Structural and kinetic analyses of herpes simplex virus type 1 latency associated transcripts in human trigeminal ganglia and in cell culture
... demonstrate that in human trigeminal ganglia, the smaller (1.35 kb) HSV-1 transcript differs from the larger (1.85 kb) LAT by excision of an intron near its 5' end; they are otherwise ... See full document
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The abundant latency-associated transcripts of herpes simplex virus type 1 are bound to polyribosomes in cultured neuronal cells and during latent infection in mouse trigeminal ganglia.
... HSV-1 latency-associated proteins have yet been convincingly demonstrated and antibodies raised against syn- thetic fragments of the LATs’ two ORFs did not identify pro- teins of the expected size ... See full document
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Quantitation of herpes simplex virus type 1 DNA and latency-associated transcripts in rabbit trigeminal ganglia demonstrates a stable reservoir of viral nucleic acids during latency.
... Herpes simplex virus type 1 (HSV-1), an alphaherpesvirus, is neurotropic and establishes lifelong latency in the nervous ...of virus into axon terminals and viral ... See full document
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Expression of Herpes Simplex Virus 1-Encoded MicroRNAs in Human Trigeminal Ganglia and Their Relation to Local T-Cell Infiltrates
... Herpes simplex type 1 (HSV-1) is a neurotropic virus which establishes lifelong latency in human trigeminal ganglia ...HSV-1 latency are ... See full document
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Human Thymidine Kinase Can Functionally Replace Herpes Simplex Virus Type 1 Thymidine Kinase for Viral Replication in Mouse Sensory Ganglia and Reactivation from Latency upon Explant
... Herpes simplex virus type 1 thymidine kinase exhibits a strikingly broad substrate ...does human thymidine kinase, deoxycytidine as does human deoxycytidine kinase, the ... See full document
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A Gene Capable of Blocking Apoptosis Can Substitute for the Herpes Simplex Virus Type 1 Latency-Associated Transcript Gene and Restore Wild-Type Reactivation Levels
... ocular herpes simplex virus type 1 (HSV-1) infection, the virus travels up axons and establishes a lifelong latent infection in neurons of the trigeminal ... See full document
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Herpes Simplex Virus Type 1 Latency-Associated Transcript Expression Protects Trigeminal Ganglion Neurons from Apoptosis
... HSV latency is less ...the trigeminal ganglia of ...inal ganglia, peaking at 14 days and persisting there for months (20, 24, ...infected trigeminal ganglia evade eradication by ... See full document
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Genetic Studies Exposing the Splicing Events Involved in Herpes Simplex Virus Type 1 Latency-Associated Transcript Production during Lytic and Latent Infection
... Herpes simplex virus type 1 (HSV-1) establishes latency in sensory neurons, a state in which the viral lytic genes are silenced and only the latency locus is ... See full document
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Evidence that two latency-associated transcripts of herpes simplex virus type 1 are nonlinear.
... The latency-associated transcripts (LATs) of herpes simplex virus type 1 (HSV-1) are the only viral gene products that accumulate to abundant levels in ... See full document
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Analysis of Individual Human Trigeminal Ganglia for Latent Herpes Simplex Virus Type 1 and Varicella-Zoster Virus Nucleic Acids Using Real-Time PCR
... Polyadenylated transcripts mapping to VZV genes 21, 29, and 63 have been detected in RNA extracted from latently infected human ...62 transcripts have been de- tected by Northern blot analysis of ... See full document
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Herpes Simplex Virus Type 1 Latency-Associated Transcripts Suppress Viral Replication and Reduce Immediate-Early Gene mRNA Levels in a Neuronal Cell Line
... During herpes simplex virus type 1 (HSV-1) latent infection in human dorsal root ganglia, limited viral transcription, which has been linked to HSV-1 ... See full document
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A 348-base-pair region in the latency-associated transcript facilitates herpes simplex virus type 1 reactivation.
... of herpes simplex virus type 1 have a reduced capacity to reactivate following adrenergic induction in the rabbit eye ...This virus, 17 D 348, expresses LAT but exhibits a ... See full document
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A herpes simplex virus type 1 latency-associated transcript mutant reactivates with normal kinetics from latent infection.
... Expression of herpes simplex virus type 1 latency-associated transcripts in the trigeminal ganglia of mice during acute infection and reactivation of latent infection.. Expression of her[r] ... See full document
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Herpes Simplex Virus Type 1 Latency-Associated Transcript Reduces Human Neuroblastoma Cell Proliferation
... Herpes simplex virus type 1 latency associated transcript is plentifully expressed through virus ...MTT, cell proliferation and gene expression analysis ... See full document
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The High Prevalence of Herpes Simplex Virus Type 1 DNA in Human Trigeminal Ganglia Is Not a Function of Age or Gender
... the human TG and that this variability is unrelated to gender, age, or ...of human subjects (89.1%) are positive for HSV-1 DNA in ...and latency are widespread in divergent human ... See full document
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Detection of latency-related viral RNAs in trigeminal ganglia of rabbits latently infected with herpes simplex virus type 1.
... The rightward synthesized probe 3A that is complementary to ICPO mRNA did not hybridize with trigeminal ganglionic tissue from any of 22 latently infected rabbits, indicating that the ma[r] ... See full document
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Relationship between polyadenylated and nonpolyadenylated herpes simplex virus type 1 latency-associated transcripts.
... In contrast to the results with polyA+ RNA, polyA- RNA from infected rabbit skin cells and polyAor total RNA from latently infected murine sensory nerve ganglia protected a 190-base frag[r] ... See full document
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Gene expression during reactivation of herpes simplex virus type 1 from latency in the peripheral nervous system is different from that during lytic infection of tissue cultures.
... gested that the regulation of HSV gene expression in neuronal cells of the TG is different from the regulatory cascade in cell types such as Vero cells (27). Other studies have also found different patterns of ... See full document
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Expression of herpes simplex virus type 1 (HSV-1) latency-associated transcripts and transcripts affected by the deletion in avirulent mutant HFEM: evidence for a new class of HSV-1 genes.
... 3281 Downloaded from http://jvi.asm.org/ on November 10, 2019 by guest During latent herpes simplex virus type 1 HSV-1 infection in the trigeminal ganglia of mice, three virus-specific t[r] ... See full document
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Monoclonal antibodies suppress replication of herpes simplex virus type 1 in trigeminal ganglia.
... Since virus neutralization, CML, and ADCC do not account for the capacity of monoclonal antibodies to suppress virus growth within either ganglionic or neuroblastoma cell cultures, we ar[r] ... See full document
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