Anticancer complexes
Organometallic osmium arene anticancer complexes
... similar/better anticancer activity as ...ruthenium anticancer complexes, two Ru(III) complexes are already undergoing clinical trials: NAMI-A and ...Their anticancer mechanism of action ...
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Sequence dependent attack on peptides by photoactivated platinum anticancer complexes
... observation of Met and Trp oxidation by this class of photo- activatable platinum anticancer complexes. Trp modication yielded hydroxytryptophan (HTRP) and N-formylkynurenine (NFK) species (Scheme 2), ...
7
Design and mechanism of action of organometallic anticancer complexes
... Mechanisms of cellular Pt uptake from cisplatin and cellular accumulation of Pt have been widely investigated, 11,14 however little is known about analogous pathways involved in the uptake of half-sandwich ruthenium ...
345
New activation mechanism for half sandwich organometallic anticancer complexes
... active anticancer complexes in the limited set we have studied here, are those that have activated Cp x rings (Table ...of complexes will be studied in future ...
10
Cucurbit[n]uril binding of platinum anticancer complexes
... and off movement of cucurbituril, resulting in binding kinetics that are slow on the NMR timescale for the metal complex. Although the dpzm ligand has relatively few rotamers, encapsulation by the larger Q[8] resulted in ...
8
Mitochondria targeted spin labelled luminescent iridium anticancer complexes
... complexes containing one and two TEMPO nitroxide spin labels. They are highly luminescent with long emission life- times (33–155 ns). In the complex Ir-TEMPO2, unlike in the free bisTEMPO ligand (L2), there is a ...
9
Catalytic organometallic anticancer complexes
... * complexes (Cp * = 1,2,3,4,5-cyclopentamethyl) were also ...The complexes are derived from the reputable ruthenium(II) chemistry pioneered by Professor Ryoji ...
275
Unusual DNA binding modes for metal anticancer complexes
... The most relevant feature of this special DNA binding is the lack of severe DNA distortions such as a kink, or significant unwinding of the helices, which are characteristic of DNA adducts of mononuclear platinum ...
73
Aqueous solution chemistry of ruthenium arene anticancer complexes
... Ruthenium(II) complexes with pyridine derivatives have many chemical purposes, from solar cell devices 1 to potential anticancer drugs 2 . The pyridine derivative ligands have varying electronic effects on ...
304
Design, synthesis and activation of ruthenium arene anticancer complexes
... for complexes containing N,N' chelating ligands such as bpm, phen and bathophen as well as different arenes such as p-cym, hmb, ind and ...all complexes are thermodynamically preferred compared to their ...
397
Design and mechanism of action of novel organoiridium(iii) azopyridine anticancer complexes
... azopyridine complexes as cancer cells have higher levels of basal ROS than normal cells and are more sensitive to perturbations in their redox balance, thus cancer cells can be selectively killed whilst minimising ...
331
Organometallic iridium(III) cyclopentadienyl anticancer complexes containing C,N chelating ligands
... methods. Complexes 2 and 5 were refined against F 2 using SHELXL 9 , and hydrogen atoms were added at calculated positions and refined riding on their parent ...
30
Pharmaco genomic investigations of organo iridium anticancer complexes reveal novel mechanism of action
... Complex 1 also has an additional phenyl substituent on the cyclopentadienyl ring, which not only enhances lipophilicity but can also intercalate between DNA bases if that is an attack site. However, interestingly, the Cp ...
16
Photodecomposition pathways for photoactivatable platinum(IV) diazido anticancer complexes
... The formation of the 1,2-(GpG) crosslinks have been determined by both X-ray crystallography and nuclear magnetic resonance (NMR) methods. 59-61 These CDDP-DNA crosslinks distort the DNA molecule resulting in unwinding ...
367
Computer aided drug design of photoactivated platinum anticancer complexes
... platinum complexes have proven successful as anticancer agents in the clinic and in clinical ...the anticancer treatments in widespread use today were developed prior to 1975, at a time when the ...
201
Application of analytical techniques for the study of metal based anticancer complexes
... arene complexes, the enantiomers of which were stable in solution for over 3 ...Ir(III) complexes with chiral metal centres epimerized within 2 h in solution at ambient ...
276
In cell activation of organo osmium(II) anticancer complexes
... exhibit good stability in both phosphate-buffered saline and blood serum. In contrast, once taken up by MCF-7 cells, the iodide ligand is rapidly pumped out. Intriguingly, GSH catalyzes their hydrolysis. The resulting ...
5
Organometallic iridium anticancer complexes
... metal complexes which possess anticancer ...metal-based anticancer drugs may be able to widen the spectrum of treatable cancers, reduce toxic side-effects, and overcome platinum ...organometallic ...
259
Organometallic half sandwich iridium anticancer complexes
... metal complexes which possess anticancer ...metal-based anticancer drugs may be able to widen the spectrum of treatable cancers, reduce toxic side-effects, and overcome platinum ...organometallic ...
54
Photoactivatable platinum (IV) anticancer complexes
... 6 Other strategies for the development of new Pt drugs have also been explored leading to the discovery of the second (changing the leaving group) and third generation (changing ammines) anticancer drugs. From all ...
279