cluster-randomized trials
Balance algorithm for cluster randomized trials
... clinical trials it was advised that deterministic designs should be avoided and a random element included ...be randomized it can offer substantial ...for cluster randomized trials ...
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Comparison of population-averaged and cluster-specific models for the analysis of cluster randomized trials with missing binary outcomes: a simulation study
... some randomized participants ...for cluster randomized trials, there is a higher risk that the vari- ance of effect estimate will be underestimated with single imputation ...
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A systematic review of factors affecting children’s right to health in cluster randomized trials in Kenya
... using cluster randomization, if trials involved children aged between zero and eighteen, and if study sites were located in ...in cluster trials since Treatment Action Campaign was initiated ...
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Choosing an imbalance metric for covariate constrained randomization in multiple arm cluster randomized trials
... In cluster-randomized controlled trials (C-RCTs), the clustered nature of intervention and data present added statistical and logistical complexities, suggesting the re- quirement for even more ...
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Propensity score to detect baseline imbalance in cluster randomized trials: the role of the c-statistic
... In cluster randomized trials (CRTs), the units of random- ization are not individuals but rather the social units to which the individuals belong ...sometimes randomized before the ...
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Sample size calculations for the design of cluster randomized trials: A summary of methodology.
... clinical trials in which individual subjects are each randomized to receive one of the therapeutic options or interventions under test, the distinctive characteristic of a cluster trial is that ...
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Ethical and policy issues in cluster randomized trials: rationale and design of a mixed methods research study
... and cluster level; and details of the ethics review ...20 trials will be used for reviewer ...300 trials is sufficient to give a 95% two-sided confidence interval extending ± ...with Cluster ...
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Ethical issues posed by cluster randomized trials in health research
... Cluster randomized trials only partly fit within the cur- rent paradigm of research ...First, cluster trials involve groups rather than (merely) individuals, and our understanding of ...
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Methods for analyzing cost effectiveness data from cluster randomized trials
... alongside cluster randomized trials that have individual cost ...alongside cluster randomized trials have used boot- strapping to deal with asymmetrically distributed costs ...
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Intracluster correlation coefficients in cluster randomized trials: empirical insights into how should they be reported
... interventions. Trials that randomize by groups are known as cluster randomized trials ...these trials requires special ...same cluster may be correlated – that is, the outcomes ...
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A priori postulated and real power in cluster randomized trials: mind the gap
... average cluster size), the higher the power ...are randomized, with no loss of power because of correlation between ...increasing cluster size improves the power up to a certain threshold, which ...
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Researchers’ perceptions of ethical challenges in cluster randomized trials: a qualitative analysis
... of Cluster Randomized Trials [13] may be helpful in addressing variation in ethics review among research ethics committees while simultaneously clarifying for researchers when informed consent ...
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Ethical Challenges in Cluster Randomized Trials
... in cluster-cluster trials 1-3,7-9 ...Healthcare Cluster Randomized Trials?” we developed a principled definition of “research subject” 10 ...from cluster members who are ...
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How large are the consequences of covariate imbalance in cluster randomized trials: a simulation study with a continuous outcome and a binary covariate at the cluster level
... controlled trials are considered the gold standard for evaluating the effect of a new treatment relative to an old treatment, a placebo or no treatment at ...in trials that are offered in naturally existing ...
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Cluster randomized trials utilizing primary care electronic health records: methodological issues in design, conduct, and analysis (eCRT Study)
... Conclusions: Cluster randomized trials may be performed efficiently in large samples from UK general practices using the electronic health records of a primary care ...
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Statistical analysis and handling of missing data in cluster randomized trials: a systematic review
... in trials and reduce the potential for ...all randomized clusters and in- dividuals in order to limit the extent of missing data, (2) perform a primary analysis that is valid under a plausible missingness ...
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What is the role and authority of gatekeepers in cluster randomized trials in health research?
... when cluster members are approached for consent at the earliest opportunity and before any study interventions or data-collection procedures have ...when cluster-level interventions or cluster size ...
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Allocation techniques for balance at baseline in cluster randomized trials: a methodological review
... The pharmaceutical industry [50] and other commen- tators [51] warn against the use of minimization mainly due to higher risk of selection bias that comes with pre- dictability of deterministic assignment. The extent of ...
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Ethical issues in the design and conduct of stepped wedge cluster randomized trials in low resource settings
... SW-CRTs are increasingly popular in health-related research [1] in both high- and low-resource settings [5]. Although the same ethical principles apply to the use of these designs in both settings [4], there may be ...
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Variability in research ethics review of cluster randomized trials: a scenario based survey in three countries
... There are many aspects of CRTs that complicate their ethical design, conduct and review (beyond the statistical complications) [3,8-10]. In the absence of guidance tai- lored to CRTs, researchers and research ethics ...
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