Complement factor H and Complement C4b binding protein 128
Does Binding of Complement Factor H to the Meningococcal Vaccine Antigen, Factor H Binding Protein, Decrease Protective Serum Antibody Responses?
... b Factor H binding protein (fHbp) is a principal antigen in a multicomponent meningococcal vaccine recently licensed in Europe for prevention of serogroup B ...The protein recruits the ...
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Kinetic Analysis of the Interactions between Vaccinia Virus Complement Control Protein and Human Complement Proteins C3b and C4b
... the factor I cofactor activity of VCP for C3b and ...for C4b than ...relative factor I cofactor activity of VCP for C3b and ...in factor I-mediated cleavage of C3b and ...or C4b were ...
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Human Complement Regulators C4b Binding Protein and C1 Esterase Inhibitor Interact with a Novel Outer Surface Protein of Borrelia recurrentis
... binds factor H, the regulator of the alternative pathway of complement activation, thereby inhibiting complement mediated ...acquire C4b-binding protein (C4bp) and human ...
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Role of complement factor H in pneumococcal infections
... affect binding of factor H and complement deposition on the pneumococcal surface? Chapter 1 provides background knowledge of infections by ...the complement system. The three main ...
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Heterogeneity in Rhesus Macaque Complement Factor H Binding to Meningococcal Factor H Binding Protein (FHbp) Informs Selection of Primates To Assess Immunogenicity of FHbp-Based Vaccines
... Jiang H, Liu Y, Messina DN, Shen Y, Song HX, Wylie T, Zhang L, Birney E, Han K, Konkel MK, Lee J, Smit AF, Ullmer B, Wang H, Xing J, Burhans R, Cheng Z, Karro JE, Ma J, Raney B, She X, Cox MJ, Demuth JP, ...
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A Novel Monoclonal Antibody against FbaA Can Inhibit the Binding of the Complement Regulatory Protein Factor H to Group A Streptococcus
... human complement regulatory proteins, such as factor H (FH) and factor H-like protein 1 (FHL-1), for immune ...FH binding protein expressed on the surface of group ...
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Complement factor H binding by different Lyme disease and relapsing fever Borrelia in animals and human
... ligand binding experiments, 2-D electrophoresis, and protein identification and peptide de novo sequencing based on mass spectrometry, revealed novel fH putative binding proteins of Lyme- and ...
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Complement factor H dysfunction in atypical hemolytic uremic syndrome
... in binding site mapping studies because disruption of the interface may lead to loss-of-function due to change in the interdomain orientation instead of disruption of the ...human protein sequence on ...
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Complement regulation by heparan sulfate and factor H on the endothelial glycocalyx
... by binding the correct HS domains, which significantly increases the affinity for C3b (Figure ...the protein folds back on itself, bringing the N- and C- terminus in close proximity and theoretically ...
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Human C3 glomerulopathy provides unique insights into complement factor H–related protein function
... FH binding activity to surface-fixed C3 fragments that is encom- passed within SCR19–SCR20, impairing the ability of FH to block surface complement ...mutant protein in the patients with C3G assem- ...
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Self-damage caused by dysregulation of the complement alternative pathway: Relevance of the factor H protein family
... FHR-1 protein was identified in a Spanish family with C3G by Western blot analysis ...This protein was generated by an internal duplication of the CFHR1 gene, and contains two copies of domains CCPs ...
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Factor H autoantibodies and deletion of Complement Factor H Related protein 1 in rheumatic diseases in comparison to atypical hemolytic uremic syndrome
... FH, factor I (FI) and C4b-binding protein (C4BP) were measured by ELISA, while CFHR1 homozygous deletion was determined with Western blotting of ...
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Staphylococcus aureus surface protein SdrE binds complement regulator factor H as an immune evasion tactic
... fH-binding protein via mass spectrometric analysis of ...this protein to bind fH whether purified or in serum, with a time- and dose- dependent relationship ...decreased complement-mediated ...
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Identification of Complement Regulatory Domains in Vaccinia Virus Complement Control Protein
... erythrocytes; factor H was included as a positive control. As expected, factor H showed reduced alter- native pathway C3 convertase decay-accelerating activity on neuraminidase-treated cells ...
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Biophysical analysis of sialic acid recognition by the complement regulator Factor H
... Complement factor H (FH), an elongated and substantially glycosylated 20-domain protein, is a soluble regulator of the complement alternative pathway ...glycan binding sites ...
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Complement Factor H C-terminus and its significance : a structural narrative
... nephritic factor, ...This factor causes enhanced complement activation by stabilizing the convertase or limiting down regulation of the ...plasma complement control ...defective protein ...
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Dissecting the Regions of Virion-Associated Kaposi's Sarcoma-Associated Herpesvirus Complement Control Protein Required for Complement Regulation and Cell Binding
... against complement-mediated elimination, evolutionary pressure would yield KCP expression on the sur- faces of cells infected de novo and on the surfaces of extracel- lular KSHV ...virion binding to cells ...
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COMPLEMENT PATHWAYS OF COMPLEMENT ACTIVATION:
... accelerating factor (DAF) prevents the binding of Factor ...serum protein, factor H, can displace factor B and bind to ...C3b. Binding of factor H ...
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Structural basis for complement factor H linked age-related macular degeneration
... this binding site is dominated by hydrogen bonds and Van der Waals contacts with the backbone, with an additional contribution from the more distant positively charged Lys405 (which has been previously implicated ...
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Is complement factor H a shared risk factor for age-related macular degeneration and cardiovascular disease?
... 1965, complement factor H (fH) is a ~150 kDa ...C3b binding sites in SCRs 1-4, SCR 12-14 and SCRs 19-20; and three binding sites for heparin/ sialic acid in SCR7, SCR 13 and SCRs 19- ...
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