Deducing protein function from structural information
The Structural Proteomics of S-Nitrosylation: From Global Identification to Elucidating Protein Function Through Structural Bioinformatics
... Harry Ischiropoulos, Ph.D. S-nitrosylation is the covalent addition of nitric oxide to reduced cysteine residues on proteins. It has been well documented that not all proteins are S-nitrosylated and more specifically, ...
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QMEANclust: estimation of protein model quality by combining a composite scoring function with structural density information
... Generally, protein structure prediction consists of a con- formational sampling step followed by a scoring step in which the best model is selected from the ...the structural density in the ensemble ...
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Protein function prediction using family-specific structural motifs
... hypothetical protein from Mehanococcus jannaschii has no detectable sequence similarity to any protein sequence in the Protein Databank ...the protein was probably a methyltransferase ...
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The Role of Structural Dynamics in Protein Function and Evolvability Muthahari, Yusran
... fix-length protein 11,13 ...whole protein sequence. To extract the protein structural information, the dynamic ensemble of the native state has been captured by using an ...
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Prediction of Protein Function and Functional Sites From Protein Sequences
... (i.e., structural neighbor profiles and distance to nearby functional sties) showed better predictive power than solvent ...the structural neighbor profile alone is nearly as powerful as residue ...
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Predicting protein function from protein/protein interaction data: a probabilistic approach
... precision out of the 669 analyzed. For these the threshold value at which 80% precision was first attained was used as the prediction threshold. Assessing precision of propagation is more difficult; we cannot reconstruct ...
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Structural Studies On Silk Protein Fibre From Pseudoscorpion
... shows structural homology as that of Bombyx mori silk ...the information of silk fibroin protein studied in other pseudoscorpion species called Neobisium maritimum (Hunt ...
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Spatial proteomics: from tissue organization to protein function
... the protein interactions Several lines of evidence suggest that gp210 acts also away from the NPC, nevertheless it remains unclear how and in which other cellular pathways it is ...related function ...
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Topology and biological function of enterovirus non-structural protein 2B as a member of the viroporin family
... 2B protein The Enterovirus genus belongs to the Picornaviridae family, which includes poliovirus, Coxsackie virus, en- teric cytopathogenic human orphan virus, and human enterovirus 71 ...ranging from 28 nm ...
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PhenoFam-gene set enrichment analysis through protein structural information
... employing structural and functional information on families of protein domains as annotation ...results from quantitative high-throughput studies (gene expression microarrays, functional RNAi ...
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Protein structural dynamics and thermodynamics from advanced simulation techniques
... 6.2.5 Definition of the “Kinetic free energy” On the basis of how many times a given configuration, defined by the values of the fraction of native contacts, is visited by the DRP a representation in analogy with the ...
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Protein function prediction by integrating sequence, structure and binding affinity information
... new protein sequences (265 million and counting) and experimental examinations of every protein in all its possible functional categories are simply ...computational function-prediction tools that ...
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The development of machine learning based software for predicting protein-protein interactions and protein function from protein primary structure
... ligand-binding protein is haemoglobin, which transports oxygen from the lungs to other organs and tissues in all vertebrates and has close homologs in every biological ...kingdom. Structural proteins ...
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Protein Structure and Function
... Some structural differences were observed in the heavy metal binding site and in loops that change as the protein performs its functions, ...a protein structure obtained in vitro provides valuable ...
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Bacteriophages: their structural organisation and function
... portal protein) was determined at a resolution of ...capsid protein, which forms the envelope to protect viral genome from the harsh outer environment, represents a conservative fold found nowadays ...
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Function and Structure Prediction of Rv2004c, a Hypothetical Protein from M.tuberculosis
... wall protein-Rv2004c is characterized and analysed for its function with various reliable bioinformatics ...conserved protein in Mycobacterium genus and also seen in some lineage of Bacteria and it ...
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Structural versatility that serves the function of the HRD motif in the catalytic loop of protein tyrosine kinase, Src
... of protein tyrosine kinases, and it requires the generation, expression, purification, and analysis of each mutant ...directly from Agar plates to nitrocellulose membrane, the colonies were cultured in ...
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The subcellular localization of the hepatitis C virus non-structural protein NS2 is regulated by an ion channel-independent function of the p7 protein
... As well as a redistribution of NS2, biochemical character- ization revealed that the presence of the upstream SPp7 sequence resulted in the accumulation of NS2 in a detergent-insoluble fraction. It is unclear whether the ...
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Decoding post-stroke motor function from structural brain imaging
... benefited from machine learning methods, which have the ability to provide individualized predictions and to account for the interaction among units of information in the ...in structural imaging to ...
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Structural genomics of protein phosphatases
... human protein phosphatases for which there was no representative in the ...uncharacterized protein phosphatases from a number of pathogens for which sequence information was ...cloned ...
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