Dinuclear platinum complexes for use as anticancer
![Cucurbit[n]uril binding of platinum anticancer complexes](data:image/gif;base64,R0lGODlhAQABAIAAAP///wAAACH5BAEAAAAALAAAAAABAAEAAAICRAEAOw==)
Cucurbit[n]uril binding of platinum anticancer complexes
... Introduction Cisplatin is an effective drug in the treatment of human testicular, ovarian, lung, bladder, head and neck cancers. 1 The continued use of cisplatin, however, is limited by both natural and acquired ...
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Diazido platinum(IV) complexes for photoactivated anticancer chemotherapy
... other platinum-based anticancer drugs. 5,6 Platinum drugs are now used to treat over 40% of all cancer patients in chemotherapy since cisplatin was approved by FDA in 1978 to treat testicular and ...
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Sequence dependent attack on peptides by photoactivated platinum anticancer complexes
... the use of bright red light during sample preparation and analysis had no effect on 1, while low levels of white light induced the photoactivation of the ...
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Photodecomposition pathways for photoactivatable platinum(IV) diazido anticancer complexes
... trans- platinum complexes synthesised and their cytotoxic ...trans-configured complexes in cis-platin resistant cell lines, suggested that these geometrical isomers induce their cytotoxic effect ...
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Computer aided drug design of photoactivated platinum anticancer complexes
... of platinum complexes have proven successful as anticancer agents in the clinic and in clinical ...the anticancer treatments in widespread use today were developed prior to 1975, at a ...
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Design and development of polynuclear ruthenium and platinum polypyridyl complexes in search of new anticancer agents
... of platinum and ruthenium anticancer ...clinical use and the cellular resistance to the ...mononuclear anticancer platinum and ruthenium complexes have been presented ...
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Platinum anticancer drug shortages
... The impact of a drug shortage on a patient can be significant. 24 There have been a number of reported instances of chemotherapy drug shortages in the US and Europe which have resulted in patients experiencing ...
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Organometallic iridium anticancer complexes
... current platinum drugs, there are some major drawbacks which are restricting their clinical use: they are efficient only in a limited range of cancers, some tumours can have acquired or intrinsic resistance ...
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Catalytic organometallic anticancer complexes
... widespread use of cisplatin, dosage is limited due to the side effects in normal tissue; causing nausea, vomiting, hair loss, nephrotoxicity, neurotoxicity, and hearing ...
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Tryptophan switch for a photoactivated platinum anticancer complex
... Our fi ndings have potential signi fi cance for the clinical use of complex 1 in photochemotherapy. The photodecomposition pathways for complex 1 in tumor cells and other tissues should be switchable by raising or ...
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Metal complexes as potential anticancer agents
... Chapter One 28 50 times greater than 10B, has produced some very promising results. The process involved with neutron capture by 157Gd is associated with electron internal conversion that produces Auger electron cascade ...
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Organometallic osmium arene anticancer complexes
... that platinum compounds can inhibit cell division when investigating the effect of electric fields on the growth of ...medical use was also a stimulus for researches on various metal-based anticancer ...
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Comparison of the effects of the oral anticancer platinum(IV) complexes oxoplatin and metabolite cis-diammine-tetrachlorido-platinum(IV) on global gene expression of NCI-H526 cells
... All compounds were prepared as stock solutions of 2 mg/mL in DMSO and aliquots stored at − 20 ° C. cell proliferation assay Cells were harvested, counted, and distributed into the wells of flat-bottomed 96-well ...
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In vitro cytotoxicity of combinations of dichloroacetate with anticancer platinum compounds
... single use of DCA may be insufficient to achieve significant clinical activity, combination with cytotoxic drugs is expected to potentiate antitumor therapy by converting damage to cellular components into ...
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Photoactivatable platinum (IV) anticancer complexes
... metal complexes is of crucial interest in the investigation of their ...of complexes 3-6 in water were determined, as described in Chapter 2 (section ...
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New platinum and palladium complexes: their anticancer application
... compounds. Platinum complexes can, for example, be attached to doxorubicin, an anthracycline antibiotic which intercalates DNA and is commonly used in the treatment of various types of ...cancer. ...
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Photoactivatable cell selective dinuclear trans diazido platinum(IV) anticancer prodrugs
... of complexes for 2 h had no effect on EtBr ...the dinuclear complexes 1 and 4 due to irradiation resulting in the release of two mononuclear fragments similar to those from ...
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Interactions between anticancer active platinum complexes and non-coding RNAs/microRNAs
... the anticancer activity of cisplatin, carboplatin and oxaliplatin, the combination of MRX34 with platinum complexes appears to be promising for future clinical trials of various solid tumor ...
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Synthesis, characterization, photochemistry and anticancer activity of novel photoactivatable platinum(IV) diazidodihydroxido complexes
... improved anticancer agents in the many analogues of cisplatin, little improvement in spectrum of activity had been ...active anticancer agents such as CDK inhibitor bohemine 67 or dichloroacetate 68 in ...
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Multifaceted studies of the DNA interactions and in vitro cytotoxicity of anticancer polyaromatic platinum(II) complexes
... these complexes to cancerous ...for complexes 3–6; 4 and 5 were the most and least effective in both areas, respectively, while 3 and 6 were approximately equal in both DNA affinity and ...Interestingly, ...
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