expression quantitative trait loci
Principles of microRNA Regulation Revealed Through Modeling microRNA Expression Quantitative Trait Loci
... using expression quantitative trait loci (eQTLs) whose regulatory effects represent a natural source of perturbation of cis -regulatory ...
22
Genetic complexity at expression quantitative trait loci
... of expression quantitative trait loci (eQTL) and assess evidence for allelic ...lymphocyte expression levels were significantly heritable, making them appropriate candidate traits for ...
5
Rapid and robust association mapping of expression quantitative trait loci
... gene expression quantitative trait loci (eQTL) in a mixed model ...on expression variability effectively reduced the number of tests by nearly ...
5
Loci nominally associated with autism from genome-wide analysis show enrichment of brain expression quantitative trait loci but not lymphoblastoid cell line expression quantitative trait loci
... for expression quantitative trait loci (eQTL) in relevant tissues ...the expression of genes are more likely to be associated with disease phenotypes ...genome-wide expression ...
11
Identification of expression quantitative trait loci by the interaction analysis using genetic algorithm
... on quantitative traits have been reported to interact with other ...The expression values of three cancer-related genes were selected from the expression data of the Genetic Analysis Workshop 15 ...
5
Controlling for false positive findings of trans hubs in expression quantitative trait loci mapping
... gene expression technol- ogy enables quantitative geneticists to conduct systematic, genome-wide linkage analysis to detect genomic loci that control gene-expression ...of expression ...
6
Overlap of expression Quantitative Trait Loci (eQTL) in human brain and blood
... The pathophysiology of many neurological and psychi- atric conditions is often localized to specific brain regions. For example, prefrontal and temporal cortex abnormal- ities have been repeatedly associated with ...
11
Expression Quantitative Trait Loci Analysis of 13 Genes in the Rat Prostate
... prostate-specific expression of transgenes (G reenberg et ...various expression levels when quantitative RT-PCR was ...in expression level was difficult to detect using a microarray, the ...
8
Expression quantitative trait loci in the developing human brain and their enrichment in neuropsychiatric disorders
... gene expression in the fetal brain and risk for neuropsychiatric disorders do not, for the most part, appear to be ...reduced expression in association with genetic risk for schizophrenia, has been found to ...
13
Comprehensive promoter level expression quantitative trait loci analysis of the human frontal lobe
... an expression profiling technique allows the identification of eQTLs for specific TSSs of ...risk loci with the individual transcripts of a gene instead of measuring the effect on all gene tran- scripts ...
15
Joint Analysis of Multiple Gene Expression Traits to Map Expression Quantitative Trait Loci
... major expression regulatory region on chromosome III, affecting more than half of the gene expression levels of individual amino acid biosynthetic ...gene expression of LEU2 does not have a QTL in ...
164
Co-regulatory expression quantitative trait loci mapping: method and application to endometrial cancer
... and loci for further investigation, as telomerase has long been considered an attractive target for therapy in endometrial carcinoma [44] and more recently, a mouse model of endometrial cancer showed that telomere ...
14
The role of heritability in mapping expression quantitative trait loci
... traits, 23 of them have estimated heritability of 0. Our study suggests that significant genome regions can be identified even for genes with low heritability estimates, indicating that heritability may not be a reliable ...
5
Weak sharing of genetic association signals in three lung cancer subtypes: evidence at the SNP, gene, regulation, and pathway levels
... tissue expression quantitative trait loci (eQTL) and enhancer datasets for evidence of a regulatory function for each SNP and identified their target ...
14
Using omics approaches to understand pulmonary diseases
... wide expression quantitative trait loci (eQTL) studies, the most common paired approach, involve the meas- urement of associations between genetic variants and gene expression ...of ...
20
Functional Haplotype and eQTL Analyses of Genes Affecting Cadmium Content in Cultivated Rice
... performed expression quantitative trait loci (eQTLs) analysis for genome-wide association studies (GWAS) candidate gene and annotated Cd ...gene expression have been widely used in ...
17
Convergent evidence from systematic analysis of GWAS revealed genetic basis of esophageal cancer
... as expression quantitative trait loci (eQTL) analysis, pathway based analysis, and network analysis, the integrative genomics approach could provide systematic evidence to genetic basis of ...
9
Weiser_unc_0153D_15713.pdf
... associated loci fall outside of protein coding regions, suggesting a role in regulatory ...Additionally, expression quantitative trait loci (eQTL) studies mapping the genetic basis of ...
126
Elucidating Molecular Networks That Either Affect or Respond to Plasma Cortisol Concentration in Target Tissues of Liver and Muscle
... used trait-correlated expression analysis, screening for expression quantitative trait loci (eQTL), genome-wide association (GWA) studies, and causality modeling to identify ...
21
Comparison of strategies for identification of regulatory quantitative trait loci of transcript expression traits
... Heritability was estimated using maximum likelihood variance decomposition methods in SOLAR [5,6]. Genome scans were performed using multipoint variance- components models that test for linkage between traits and genetic ...
7